Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Linette Ruston"'
Autor:
Parmesh Gajjar, Jake Dickinson, Harri Dickinson, Linette Ruston, Hitesh B Mistry, Claire Patterson, Paul A Dickinson
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
Demonstrating bioequivalence (BE) is important for the development of lower-cost generic products, and also for approving post-submission manufacturing changes. However, for many complex parenteral products, BE demonstration can be very challenging.
Externí odkaz:
https://doaj.org/article/c0cbd0c6968b4276bb1ea30e5eb83198
Autor:
Linette Ruston
Publikováno v:
Biopharmaceutics. :99-111
Autor:
Parmesh Gajjar, Jake Dickinson, Harri Dickinson, Linette Ruston, Hitesh B. Mistry, Claire Patterson, Paul A. Dickinson
Publikováno v:
Gajjar, P, Dickinson, J, Dickinson, H, Ruston, L, Mistry, H B, Patterson, C & Dickinson, P A 2022, ' Determining bioequivalence possibilities of long acting injectables through population PK modelling ', European Journal of Pharmaceutical Sciences, vol. 179, pp. 106296 . https://doi.org/10.1016/j.ejps.2022.106296
Long acting injectables (LAI) products are a popular intervention for treating a number of chronic conditions,with their long drug release reducing the administration frequency and thus improving patient adherence.The extended release, however, can p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215bae9bda3603ee7c158672ee47c0ab
https://doi.org/10.1016/j.ejps.2022.106296
https://doi.org/10.1016/j.ejps.2022.106296
Autor:
Alex Mattinson, David Lindley, Helena Engman, Manthena V.S. Varma, Anh-Thu Nguyen-Trung, Binfeng Xia, Xavier Pepin, Linette Ruston, Wei Zhu, Bill van Osdol, Celine Ollier, David Good, Jonathan Brown, Laurent Boulu, Talia Flanagan, Olivier Nicolas, Staffan Berg, Shanoo Budhdeo, Aarti Patel, Jan Bevernage, Handan He, Sweta Modi, Richard Barker, Claire Jackson, Christer Tannergren, Xiojun Ren, Stephane Beilles, J. Matthew Wood, Johanna Laru, Pierre Daublain, Sara Carlert, Louis Henrion, Jean-Flaubert Nguefack, Gunilla Hanisch, Eva Karlsson, Wen Lin, Shruthi Vaidhyanathan, Robert Carr, Fan Wu, Jin Zhang, Amais Ahmad, James M. Mullin, Sari Pappinen, Andrea Moir, Ke Szeto, Christine Xu, Claire Patterson, David B. Turner, Guillaume Louit, Yuya Wang, Tycho Heimbach, Richard Lloyd, Frans Franek, Masoud Jamei, Christophe Tistaert, Bertil Abrahamsson, Kerstin Julia Schäfer, Leon Aarons, Shriram M. Pathak, Adam S. Darwich, Suet Wong, Dónal Murphy, Amin Rostami-Hodjegan, Timo Korjamo, Helena Thörn, Kartrin Schmid, Michael B. Bolger, Johanna Tuunainen, Mai Anh Nguyen
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 156:50-63
Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation characteristics and their interplay with gastrointestinal physiology and biology. Physiological-based pharmacokinet
Autor:
Nanhua Deng, Sameer Kawatkar, Haoyu Wang, Michael Zinda, Allan Wu, Neil P. Grimster, Scott Throner, Kirsten Bell, Claudio Chuaqui, Richard Woessner, Xian You Peng, Wenzhan Yang, Huawei Chen, Qibin Su, Xiaohui Pei, Jon Read, Erica Banks, Melissa Vasbinder, Andrew D. Ferguson, Paul Lyne, Zhanlei Tang, Linette Ruston, Jason Grant Kettle, Jon Winter-Holt, Geraldine Bebernitz, Stephen Fawell, Cassandra F. Borenstein
Publikováno v:
Journal of Medicinal Chemistry. 63:4517-4527
JAK1, JAK2, JAK3, and TYK2 belong to the JAK (Janus kinase) family. They play critical roles in cytokine signaling. Constitutive activation of JAK/STAT pathways is associated with a wide variety of...
Autor:
Qibin, Su, Erica, Banks, Geraldine, Bebernitz, Kirsten, Bell, Cassandra F, Borenstein, Huawei, Chen, Claudio E, Chuaqui, Nanhua, Deng, Andrew D, Ferguson, Sameer, Kawatkar, Neil P, Grimster, Linette, Ruston, Paul D, Lyne, Jon A, Read, Xianyou, Peng, Xiaohui, Pei, Stephen, Fawell, Zhanlei, Tang, Scott, Throner, Melissa M, Vasbinder, Haoyu, Wang, Jon, Winter-Holt, Richard, Woessner, Allan, Wu, Wenzhan, Yang, Michael, Zinda, Jason G, Kettle
Publikováno v:
Journal of medicinal chemistry. 63(9)
JAK1, JAK2, JAK3, and TYK2 belong to the JAK (Janus kinase) family. They play critical roles in cytokine signaling. Constitutive activation of JAK/STAT pathways is associated with a wide variety of diseases. Particularly, pSTAT3 is observed in respon
Autor:
Haixia Wang, Marat Alimzhanov, Paul Lyne, Jason Grant Kettle, Jie Shi, Aarti Kawatkar, Linette Ruston, Geraldine Bebernitz, Richard Woessner, Dennis Huszar, Melissa Vasbinder, Michael Zinda, Weijia Zheng, Andrew D. Ferguson, Thomas Gero, Scott Throner, Patricia Schroeder, Kirsten Bell, Minwei Ye, Neil P. Grimster, Allan Wu, Caroline Rivard Costa, Qibin Su, Dorin Toader, Claudio Chuaqui, Jon Read, Andreas Harsch, Tracy L. Deegan, Erica Anderson
Publikováno v:
Journal of Medicinal Chemistry. 61:5235-5244
Janus kinases (JAKs) have been demonstrated to be critical in cytokine signaling and have thus been implicated in both cancer and inflammatory diseases. The JAK family consists of four highly homologous members: JAK1-3 and TYK2. The development of sm
Autor:
Lara Ward, Stephen Green, Kevin Hudson, Martina Fitzek, Benedicte Delouvrie, Craig S. Harris, Linette Ruston, Christine Lambert-van der Brempt, Sabina Cosulich, Ken Page, Barlaam Bernard Christophe, Gilles Ouvry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2679-2685
Starting from compound 1, a potent PI3Kα inhibitor having poor general kinase selectivity, we used structural data and modelling to identify key exploitable differences between PI3Kα and the other kinases. This approach led us to design chemical mo
Autor:
Gordon S. Currie, Kurt Gordon Pike, Janet D. Culshaw, Martin Pass, Kristy Gill, M. Raymond V. Finlay, Stuart E. Pearson, Jonathan M. Eden, Craig A. Roberts, Linette Ruston, Kevin Blades, Sarah L. Pass, Catherine Good, Ryan Greenwood, Morris Jeffrey James, Julie Demeritt, Emma J. Williams
Publikováno v:
Journal of Medicinal Chemistry. 58:2326-2349
High throughput screening followed by a lead generation campaign uncovered a novel series of urea containing morpholinopyrimidine compounds which act as potent and selective dual inhibitors of mTORC1 and mTORC2. We describe the continued compound opt
Publikováno v:
Med. Chem. Commun.. 5:963-967
Comparison of the human plasma protein binding data for a variety of drug discovery compounds indicates that compounds tend to be slightly more bound to human plasma proteins, than compared to plasma proteins from rats, dogs or mice. However, the maj