The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development.

Autor: Archana D Siddam, Carole Gautier-Courteille, Linette Perez-Campos, Deepti Anand, Atul Kakrana, Christine A Dang, Vincent Legagneux, Agnès Méreau, Justine Viet, Jeffrey M Gross, Luc Paillard, Salil A Lachke

Publikováno v: PLoS Genetics, Vol 14, Iss 3, p e1007278 (2018)

Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, presenting a fundamental question: does signaling/transcriptio

Externí odkaz: https://doaj.org/article/305a114dda59435fa444dfce3fd60c4b

90 Focus on a clear message: conserved RNA binding proteins function in mRNA control in eye lens development and their deficiency causes cataract

Autor: Archana D. Siddam, Agnès Méreau, Luc Paillard, Carole Gautier-Courteille, Jeffery M. Gross, David A. Scheiblin, Salil A. Lachke, Vincent Legagneux, David C. Beebe, Linette Perez-Campos, Atul Kakrana, Christine Dang, Justine Viet

Publikováno v: Journal of Biomolecular Structure and Dynamics
Journal of Biomolecular Structure and Dynamics, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2015, 33 (1), pp.58-59. ⟨10.1080/07391102.2015.1032707⟩
Journal of Biomolecular Structure and Dynamics, 2015, 33 (1), pp.58-59. ⟨10.1080/07391102.2015.1032707⟩

We study the molecular mechanisms that are essential for development and maintenance of transparency in the eye lens. Toward this goal, we have applied the bioinformatics-based gene discovery tool ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2336bf9ae643f25c7c53ffa3750bf32
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01485763