Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Lineage priming"'
Autor:
Yamada, Shinnosuke
甲第25205号
医科博第161号
新制||医科||11(附属図書館)
学位規則第4条第1項該当
Doctor of Agricultural Science
Kyoto University
DFAM
医科博第161号
新制||医科||11(附属図書館)
学位規則第4条第1項該当
Doctor of Agricultural Science
Kyoto University
DFAM
Externí odkaz:
http://hdl.handle.net/2433/288639
Akademický článek
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Autor:
Yi-Fen Lu, Patrick Cahan, Samantha Ross, Julie Sahalie, Patricia M. Sousa, Brandon K. Hadland, Wenqing Cai, Erik Serrao, Alan N. Engelman, Irwin D. Bernstein, George Q. Daley
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3178-3192 (2016)
Hematopoietic stem cell (HSC) transplantation is curative for malignant and genetic blood disorders, but is limited by donor availability and immune-mismatch. Deriving HSCs from patient-matched embryonic/induced-pluripotent stem cells (ESCs/iPSCs) co
Externí odkaz:
https://doaj.org/article/679c902f28b84dce9db31c4a72891793
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
In response to external stimuli, naïve B cells proliferate and take on a range of fates important for immunity. How their fate is determined is a topic of much recent research, with candidates including asymmetric cell division, lineage priming, sto
Externí odkaz:
https://doaj.org/article/f88b1b8b71cb41e197c345aaf121afea
Autor:
Jamie Trott, Alfonso Martinez Arias
Publikováno v:
Biology Open, Vol 2, Iss 10, Pp 1049-1056 (2013)
Summary Understanding how interactions between extracellular signalling pathways and transcription factor networks influence cellular decision making will be crucial for understanding mammalian embryogenesis and for generating specialised cell types
Externí odkaz:
https://doaj.org/article/36ec692ad9d94be898393ffa1074fd14
Autor:
Robert S Illingworth, Jurriaan J Hölzenspies, Fabian V Roske, Wendy A Bickmore, Joshua M Brickman
Publikováno v:
eLife, Vol 5 (2016)
Mouse embryonic stem cells (ESCs), like the blastocyst from which they are derived, contain precursors of the epiblast (Epi) and primitive endoderm (PrEn) lineages. While transient in vivo, these precursor populations readily interconvert in vitro. W
Externí odkaz:
https://doaj.org/article/8d105fc4d56c431b8404dce054db65fc
Autor:
Emery H. Bresnick, Shihui Ma, Zhijian Xiao, Lihong Shi, Di Wang, Jiaxi Zhou, Jingyuan Tong, Juan Li, Yanhong Zhao, Mankai Ju, Lei Zhang, Anthony R. Green, Ding Wang, Yuchen Gao, Dong Wang, Anqi Zhang, Stephen J. Loughran, Rongfeng Fu, Ting Sun, Ping Zhu, Tao Cheng, Puwen Tan, Renchi Yang
The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F+ myeloproliferative neoplasms (MPNs), harboring the same mutation in hematopoietic stem cells (HSCs), display diverse phenotypes, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1dc9b3f6b86c478615e11b1faa5c6e
https://www.repository.cam.ac.uk/handle/1810/318101
https://www.repository.cam.ac.uk/handle/1810/318101
Autor:
Jameson, Samantha Ann
The divergence of distinct cell populations from multipotent progenitors is poorly understood, particularly in vivo. The gonad is an ideal place to study this process because it originates as a bipotential primordium where multiple distinct lineages
Externí odkaz:
http://hdl.handle.net/10161/5028
Autor:
Sophie M Morgani, Joshua M Brickman
Publikováno v:
eLife, Vol 2 (2013)
Experiments on the social amoeba Dictyostelium discoideum show that the origins of lineage bias in this system lie in the nutritional history of individual cells. Clues to the molecular basis for this process suggest similar forces may be at work in
Externí odkaz:
https://doaj.org/article/752e829399094691aa7d1ad7b8f15d3c
Autor:
Alex Chattwood, Koki Nagayama, Parvin Bolourani, Lauren Harkin, Marzieh Kamjoo, Gerald Weeks, Christopher RL Thompson
Publikováno v:
eLife, Vol 2 (2013)
In cell culture, genetically identical cells often exhibit heterogeneous behavior, with only ‘lineage primed’ cells responding to differentiation inducing signals. It has recently been proposed that such heterogeneity exists during normal embryon
Externí odkaz:
https://doaj.org/article/182e9c597f2a40979bcd67c3f1d9d68b