Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Lineage Tree"'
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract B cell receptor (BCR) genes exposed to an antigen undergo somatic hypermutations and Darwinian antigen selection, generating a large BCR-antibody diversity. This process, known as B cell affinity maturation, increases antibody affinity, form
Externí odkaz:
https://doaj.org/article/fa415f8038d84a91b7f6089821856e9d
Autor:
Alaitz Aranburu, Erik Engström, Natalija Gerasimcik, Samuel Alsén, Alessandro Camponeschi, Ulf Yrlid, Ola Grimsholm, Inga-Lill Mårtensson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immunological memory protects our body from re-infection and it is composed of a cellular and a humoral arm. The B-cell branch with its memory B cells (MBCs), plasma cells and antibodies, formed either in a germinal centre (GC) -dependent or -indepen
Externí odkaz:
https://doaj.org/article/780fd6145b714b46a9ff27077a599e9e
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Somatic hypermutation (SHM) is an important diversification mechanism that plays a part in the creation of immune memory. Immunoglobulin (Ig) variable region gene lineage trees were used over the last four decades to model SHM and the selection mecha
Externí odkaz:
https://doaj.org/article/9f0910b463da40a1bc63a0a2de245b65
Autor:
Xingyu Yang, Christopher M. Tipton, Matthew C. Woodruff, Enlu Zhou, F. Eun-Hyung Lee, Inãki Sanz, Peng Qiu
Publikováno v:
BMC Genomics, Vol 21, Iss S9, Pp 1-11 (2020)
Abstract Background B cell affinity maturation enables B cells to generate high-affinity antibodies. This process involves somatic hypermutation of B cell immunoglobulin receptor (BCR) genes and selection by their ability to bind antigens. Lineage tr
Externí odkaz:
https://doaj.org/article/b30f5e079be94fa7b7b9721dd8712f49
Publikováno v:
Frontiers in Computer Science, Vol 3 (2021)
Single-cell methods are beginning to reveal the intrinsic heterogeneity in cell populations, arising from the interplay of deterministic and stochastic processes. However, it remains challenging to quantify single-cell behaviour from time-lapse micro
Externí odkaz:
https://doaj.org/article/012fc992637048beb319fb10857aa28b
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Resistance to anti-cancer drugs is a major cause of treatment failure. While several intracellular mechanisms of resistance have been postulated, the role of extrinsic factors in the development of resistance in individual tumor cells is still not fu
Externí odkaz:
https://doaj.org/article/806ca9b879334f16b212e8a3cdf5badc
Autor:
Shahrzad Bahrampour, Stefan Thor
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3229-3239 (2016)
The Paf1 protein complex (Paf1C) is increasingly recognized as a highly conserved and broadly utilized regulator of a variety of transcriptional processes. These include the promotion of H3K4 and H3K36 trimethylation, H2BK123 ubiquitination, RNA Pol
Externí odkaz:
https://doaj.org/article/e1d201ff2a3846a5a9f11eca3dad00f8
Autor:
Koptagel, Hazal
The investigation of the evolutionary history of organisms, both at the cellular level and at the species level, is a relevant research topic in computational biology. These investigations lead to a deeper understanding of developmental history, canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______260::c0f3c747012af9667451417664bf2ca9
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-323293
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-323293