Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Lineage Reprogramming"'
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 11, Pp 2444-2455 (2024)
Parkinson’s disease is typically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Many studies have been performed based on the supplementation of lost dopaminergic neurons to treat Parkinson’s
Externí odkaz:
https://doaj.org/article/a755e1e9f93c478dafa883a9581024a6
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 6, Pp 101395- (2024)
The liver exhibits remarkable regenerative capacity. However, the limited ability of primary human hepatocytes to proliferate in vitro, combined with a compromised regenerative capacity induced by pathological conditions in vivo, presents significant
Externí odkaz:
https://doaj.org/article/a2f7f1ad91264cc8b9b7b0647390d93c
Autor:
Kenji Kamimoto, Mohd Tayyab Adil, Kunal Jindal, Christy M. Hoffmann, Wenjun Kong, Xue Yang, Samantha A. Morris
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 97-112 (2023)
Summary: In direct lineage conversion, transcription factor (TF) overexpression reconfigures gene regulatory networks (GRNs) to reprogram cell identity. We previously developed CellOracle, a computational method to infer GRNs from single-cell transcr
Externí odkaz:
https://doaj.org/article/36245da6adcd4d28ba8dbd971ef7232b
Autor:
Chiara Galante, Nicolás Marichal, Franciele Franco Scarante, Litsa Maria Ghayad, Youran Shi, Carol Schuurmans, Benedikt Berninger, Sophie Péron
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/202037b60efe40048c7b600df82fc4cd
Autor:
Chiara Galante, Nicolás Marichal, Franciele Franco Scarante, Litsa Maria Ghayad, Youran Shi, Carol Schuurmans, Benedikt Berninger, Sophie Péron
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The proneural transcription factor Achaete-scute complex-like 1 (Ascl1) is a major regulator of neural fate decisions, implicated both in neurogenesis and oligodendrogliogenesis. Focusing on its neurogenic activity, Ascl1 has been widely used to repr
Externí odkaz:
https://doaj.org/article/668005160f64403abd45312db5c36dfd
Autor:
Yujung Chang, Sungwoo Lee, Jieun Kim, Chunggoo Kim, Hyun Soo Shim, Seung Eun Lee, Hyeok Ju Park, Jeongwon Kim, Soohyun Lee, Yong Kyu Lee, Sungho Park, Junsang Yoo
Publikováno v:
Nanomaterials, Vol 13, Iss 10, p 1680 (2023)
Gene therapy is an innovative approach in the field of regenerative medicine. This therapy entails the transfer of genetic material into a patient’s cells to treat diseases. In particular, gene therapy for neurological diseases has recently achieve
Externí odkaz:
https://doaj.org/article/65f150bd79ff4c7c9a5c473841551e8d
Autor:
Alexis Cooper, Benedikt Berninger
Publikováno v:
eLife, Vol 11 (2022)
New findings cast doubt on whether suppressing the RNA-binding protein PTBP1 can force astrocytes to become dopaminergic neurons.
Externí odkaz:
https://doaj.org/article/76e7f9be5f5c4f188174dfdc2ad680fb
Publikováno v:
eLife, Vol 11 (2022)
Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an attractive prospect of the cell-replacement therapy for Parkinson’s disease (PD). However, it is unclear whether repressing polypyrimidine tract binding protein 1 (P
Externí odkaz:
https://doaj.org/article/8a7c870e17704528b031b88fce73dbda
Autor:
Jie Zheng, Wonjin Yun, Junghyun Park, Phil Jun Kang, Gilju Lee, Gwonhwa Song, In Yong Kim, Seungkwon You
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-16 (2020)
Abstract Background Human keratinocytes and derived products are crucial for skin repair and regeneration. Despite substantial advances in engineered skin equivalents, their poor availability and immunorejection remain major challenges in skin grafti
Externí odkaz:
https://doaj.org/article/37f796a9fd4a43f0b63dc8e08cf4f92c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Platelets, the tiny anucleate cells responsible for stopping bleeding through thrombosis, are derived from hematopoietic stem cells through a series of differentiation steps. Thrombocytopenia, characterized by abnormally low blood platelet counts, ma
Externí odkaz:
https://doaj.org/article/b32ddf31a39549eaada272f72a4945d5