Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Line Mygland"'
Autor:
Line Mygland, Shoshy Alam Brinch, Martin Frank Strand, Petter Angell Olsen, Aleksandra Aizenshtadt, Kaja Lund, Nina Therese Solberg, Max Lycke, Tor Espen Thorvaldsen, Sandra Espada, Dorna Misaghian, Christian M. Page, Oleg Agafonov, Ståle Nygård, Nai-Wen Chi, Eva Lin, Jenille Tan, Yihong Yu, Mike Costa, Stefan Krauss, Jo Waaler
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102807- (2021)
Summary: Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the antiproliferativ
Externí odkaz:
https://doaj.org/article/27f687164a79487eab40d162285fd4c2
Supplementary Figures supporting the results and conclusions stated in the manuscript beyond what is shown in the main figures. This includes, inhibitor dose responses, growth response to alternative PI3K and EGFR inhibitors, molecular responses to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26947b6344a106ca7ed0246dec1f6fd7
https://doi.org/10.1158/1541-7786.22513479
https://doi.org/10.1158/1541-7786.22513479
Extensive descriptions of the materials and methods used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c63b9400a8c8fd37d45abfa405b5ed0
https://doi.org/10.1158/1541-7786.22513476.v1
https://doi.org/10.1158/1541-7786.22513476.v1
Statistical p-values of the comparisons performed during the in vitro part of the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6957c17c947326537eb7f9435db2858
https://doi.org/10.1158/1541-7786.22513473
https://doi.org/10.1158/1541-7786.22513473
Autor:
Petter Angell Olsen, Kaja Lund, Eva Lin, Nina Therese Solberg, Aleksandra Aizenshtadt, Nai-Wen Chi, Stefan Krauss, Jo Waaler, Oleg Agafonov, Shoshy Alam Brinch, Max Lycke, Tor Espen Thorvaldsen, Dorna Misaghian, Jenille Tan, Line Mygland, Yihong Yu, Christian M. Page, Ståle Nygård, Sandra Espada, Martin Frank Strand
Publikováno v:
SSRN Electronic Journal.
Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective anti-tumor agents in selected tumor cell lines and mouse models . Here, we characterized the response signatures and the in-depth mechanisms for the anti-proliferative effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e1c8258f9b37bb9fd45c8542538f738
https://doi.org/10.2139/ssrn.3796491
https://doi.org/10.2139/ssrn.3796491
Autor:
Dorna Misaghian, Jo Waaler, Sandra Espada, Line Mygland, Max Lycke, Jenille Tan, Kaja Lund, Mike Costa, Christian M. Page, Yihong Yu, Aleksandra Aizenshtadt, Martin Frank Strand, Eva Lin, Nina Therese Solberg, Nai-Wen Chi, Shoshy Alam Brinch, Tor Espen Thorvaldsen, Petter Angell Olsen, Stefan Krauss, Oleg Agafonov, Ståle Nygård
Publikováno v:
iScience
iScience, Vol 24, Iss 7, Pp 102807-(2021)
iScience, Vol 24, Iss 7, Pp 102807-(2021)
Summary Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the antiproliferative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee92b49712f8b44ba85286d1dc7ff3b
https://hdl.handle.net/11250/2836120
https://hdl.handle.net/11250/2836120
Autor:
Elisabeth Dybing, Marte Fauskanger, Nina Therese Solberg, Aleksandra Aizenshtadt, Eivind Hovig, Jo Waaler, Anders Aune Tveita, Martin Frank Strand, Shoshy Alam Brinch, Clara Hammarström, Max Lycke, Karen-Marie Heintz, Alexandre Corthay, Petter Angell Olsen, Vegard Nygaard, Kaja Lund, Sigurd Laeines Boe, Line Mygland, Stefan Krauss
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
The development of immune checkpoint inhibitors represents a major breakthrough in cancer therapy. Nevertheless, a substantial number of patients fail to respond to checkpoint pathway blockade. Evidence for WNT/β-catenin signaling-mediated immune ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2c3da10a77bd13965cbd251ff5323e
http://hdl.handle.net/10852/83116
http://hdl.handle.net/10852/83116
Autor:
Alexandre Corthay, Alam Brinch S, Kaja Lund, Sigurd Laeines Boe, Jo Waaler, Martin Frank Strand, Nina Therese Solberg, Line Mygland, Anders Aune Tveita, Angell Olsen P, Nygaard, Clara Hammarström, Max Lycke, Karen-Marie Heintz, Elisabeth Dybing, Stefan Krauss, Eivind Hovig
The development of immune checkpoint inhibitors represents a major breakthrough in cancer therapy. Nevertheless, a substantial number of patients fail to respond to checkpoint pathway blockade. β-catenin is the key transcriptional regulator of WNT/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25af44f2125e2021fb693f243775db76
https://doi.org/10.1101/526343
https://doi.org/10.1101/526343
Publikováno v:
Molecular cancer research : MCR. 16(3)
Overactivation of the WNT/β-CATENIN signaling axis is a common denominator in colorectal cancer. Currently, there is no available WNT inhibitor in clinical practice. Although TANKYRASE (TNKS) inhibitors have been proposed as promising candidates, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681d6a5e4295ce8849d6cc0850aee2c9
https://pubmed.ncbi.nlm.nih.gov/29222171
https://pubmed.ncbi.nlm.nih.gov/29222171
Publikováno v:
Biochemical and biophysical research communications. 386(4)
Wnt signaling plays an essential role in the development of mammalian central nervous system. We investigated the impact of activation/inhibition of the Wnt signaling pathway on neuronal/glial differentiation in neurospheres derived from neonatal mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e37411e240a87933509667f365edc46
https://pubmed.ncbi.nlm.nih.gov/19545542
https://pubmed.ncbi.nlm.nih.gov/19545542