Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods

Autor: Mustapha Carab Ahmed, Line K. Skaanning, Alexander Jussupow, Estella A. Newcombe, Birthe B. Kragelund, Carlo Camilloni, Annette E. Langkilde, Kresten Lindorff-Larsen

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

The inherent flexibility of intrinsically disordered proteins (IDPs) makes it difficult to interpret experimental data using structural models. On the other hand, molecular dynamics simulations of IDPs often suffer from force-field inaccuracies, and

Externí odkaz: https://doaj.org/article/86f6af80565f4194b9e0b758008f8a7f

Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies

Autor: Altair B, Dos Santos, Line K, Skaanning, Siganya, Thaneshwaran, Eyd, Mikkelsen, Cesar R, Romero-Leguizamón, Thomas, Skamris, Morten P, Kristensen, Annette E, Langkilde, Kristi A, Kohlmeier

Publikováno v: Cellular and molecular life sciences : CMLS. 79(8)

Parkinson's disease, Multiple System Atrophy, and Lewy Body Dementia are incurable diseases called α-synucleinopathies as they are mechanistically linked to the protein, α-synuclein (α-syn). α-syn exists in different structural forms which have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e703146d6b1c4e425b7a2e6f0b5cad2b
https://pubmed.ncbi.nlm.nih.gov/35882665

The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

Autor: Katrine Bugge, Saskia Bucciarelli, Birthe B. Kragelund, Line K Skaanning, Angelo Santoro, Bente Vestergaard, Thomas Skamris, Anna Maria D'Ursi, Jacob H. Martinsen, Annette Eva Langkilde

Publikováno v: Biomolecules
Biomolecules 10(8), 1192-(2020). doi:10.3390/biom10081192
Biomolecules, Vol 10, Iss 1192, p 1192 (2020)
Volume 10
Issue 8
Skaanning, L K, Santoro, A, Skamris, T, Martinsen, J H, D’Ursi, A M, Bucciarelli, S, Vestergaard, B, Bugge, K, Langkilde, A E & Kragelund, B B 2020, ' The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin ', Biomolecules, vol. 10, no. 8, 1192 . https://doi.org/10.3390/biom10081192

The intrinsically disordered protein &alpha
synuclein (aSN) is, in its fibrillated state, the main component of Lewy bodies&mdash
hallmarks of Parkinson&rsquo
s disease. Additional Lewy body components include glycosaminoglycans, inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f721977b5dc21f680ab54677d9fcb486
https://doi.org/10.3390/biom10081192