Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Line K Vibholm"'
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Akademický článek
SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity
Autor: Stine SF Nielsen, Line K Vibholm, Ida Monrad, Rikke Olesen, Giacomo S Frattari, Marie H Pahus, Jesper F Højen, Jesper D Gunst, Christian Erikstrup, Andreas Holleufer, Rune Hartmann, Lars Østergaard, Ole S Søgaard, Mariane H Schleimann, Martin Tolstrup
Publikováno v: EBioMedicine, Vol 68, Iss , Pp 103410- (2021)
Background: The SARS-CoV-2 pandemic currently prevails worldwide. To understand the immunological signature of SARS-CoV-2 infections and aid the search and evaluation of new treatment modalities and vaccines, comprehensive characterization of adaptiv
Externí odkaz: https://doaj.org/article/eb4b5ba920414fcc8e791c8269b8081f
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2
Akademický článek
Single cell analysis reveals a subset of cytotoxic-like plasmacytoid dendritic cells in people with HIV-1
Autor: Lamin B. Cham, Jesper D. Gunst, Mariane H. Schleimann, Giacomo S. Frattari, Miriam Rosas-Umbert, Line K. Vibholm, Renée M. van der Sluis, Martin R. Jakobsen, Rikke Olesen, Lin Lin, Martin Tolstrup, Ole S. Søgaard
Publikováno v: iScience, Vol 26, Iss 9, Pp 107628- (2023)
Summary: Human plasmacytoid dendritic cells (pDCs) play a central role in initiating and activating host immune responses during infection. To understand how the transcriptome of pDCs is impacted by HIV-1 infection and exogenous stimulation, we isola
Externí odkaz: https://doaj.org/article/c71981a857e54b519eb37f5423105348
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3
Akademický článek
TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodesResearch in context
Autor: Mariane H. Schleimann, Maria-Louise Kobberø, Line K. Vibholm, Kathrine Kjær, Leila B. Giron, Kathleen Busman-Sahay, Chi Ngai Chan, Michael Nekorchuk, Manuel Schmidt, Burghardt Wittig, Tine E. Damsgaard, Peter Ahlburg, Michel B. Hellfritzsch, Kaja Zuwala, Frederik H. Rothemejer, Rikke Olesen, Phillipp Schommers, Florian Klein, Harsh Dweep, Andrew Kossenkov, Jens R. Nyengaard, Jacob D. Estes, Mohamed Abdel-Mohsen, Lars Østergaard, Martin Tolstrup, Ole S. Søgaard, Paul W. Denton
Publikováno v: EBioMedicine, Vol 45, Iss , Pp 328-340 (2019)
Background: TLR9 agonists are being developed as immunotherapy against malignancies and infections. TLR9 is primarily expressed in B cells and plasmacytoid dendritic cells (pDCs). TLR9 signalling may be critically important for B cell activity in lym
Externí odkaz: https://doaj.org/article/6617a90ba47a4cea9fc13ade7be6bc01
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4
High-dose coenzyme Q10 therapy versus placebo in patients with post COVID-19 condition: a randomized, phase 2, crossover trial
Autor: Kristoffer S. Hansen, Trine H. Mogensen, Jane Agergaard, Berit Schiøttz-Christensen, Lars Østergaard, Line K. Vibholm, Steffen Leth
Publikováno v: Hansen, K S, Mogensen, T H, Agergaard, J, Schiøttz-Christensen, B, Østergaard, L, Vibholm, L K & Leth, S 2023, ' High-dose coenzyme Q10 therapy versus placebo in patients with post COVID-19 condition : a randomized, phase 2, crossover trial ', The Lancet Regional Health-Europe, vol. 24, 100539 . https://doi.org/10.1016/j.lanepe.2022.100539
Hansen, K S, Mogensen, T H, Agergaard, J, Schiøttz-Christensen, B, Østergaard, L, Vibholm, L K & Leth, S 2023, ' High-dose coenzyme Q10 therapy versus placebo in patients with post COVID-19 condition : a randomized, phase 2, crossover trial ', The Lancet Regional Health-Europe, vol. 24, pp. 100539 . https://doi.org/10.1016/j.lanepe.2022.100539
Hansen, K S, Mogensen, T H, Agergaard, J, Schiøttz-Christensen, B, Østergaard, L, Vibholm, L K & Leth, S 2022, ' High-dose coenzyme Q10 therapy versus placebo in patients with post COVID-19 condition : A randomized, phase 2, crossover trial ', The Lancet Regional Health-Europe, pp. 100539 . https://doi.org/10.1016/j.lanepe.2022.100539
Background: Post COVID-19 condition (PCC) is defined as symptoms lasting more than 12 weeks after developing COVID-19. Evidence of mitochondrial dysfunction has been reported in peripheral blood mononuclear cells obtained from patients with COVID-19.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a91bd60f11a158a559b541e0199293
https://pubmed.ncbi.nlm.nih.gov/36337437
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5
CD169 (Siglec-1) as a Robust Human Cell Biomarker of Toll-Like Receptor 9 Agonist Immunotherapy
Autor: Stine Sofie Frank Lende, Marie Høst Pahus, Ida Monrad, Rikke Olesen, Anna R. Mahr, Line K. Vibholm, Lars Østergaard, Ole Schmeltz Søgaard, Anna Halling Folkmar Andersen, Paul W. Denton, Martin Tolstrup
Publikováno v: Lende, S S F, Pahus, M H, Monrad, I, Olesen, R, Mahr, A R, Vibholm, L K, Østergaard, L, Søgaard, O S, Andersen, A H F, Denton, P W & Tolstrup, M 2022, ' CD169 (Siglec-1) as a Robust Human Cell Biomarker of Toll-Like Receptor 9 Agonist Immunotherapy ', Frontiers in cellular and infection microbiology, vol. 12, 919097 . https://doi.org/10.3389/fcimb.2022.919097
Immunotherapy is a promising therapeutic area in cancer and chronic viral infections. An important component of immunotherapy in these contexts is the activation of innate immunity. Here we investigate the potential for CD169 (Siglec 1) expression on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bca9bc0cf91f600302bdf004fd0f35
https://doi.org/10.3389/fcimb.2022.919097
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6
The Impact of IFNλ4 on the Adaptive Immune Response to SARS-CoV-2 Infection
Autor: Ole Schmeltz Søgaard, Stine S F Nielsen, Thomas R. O'Brien, Martin Tolstrup, Mariane H. Schleimann, Mads Kjolby, Ida Monrad, Giacomo S. Frattari, Line K. Vibholm, Michelle Møhlenberg, Jesper Damsgaard Gunst, Rikke Olesen, Rune Hartmann
Publikováno v: Møhlenberg, M, Monrad, I, Vibholm, L K, Nielsen, S S F, Frattari, G S, Schleimann, M H, Olesen, R, Kjølby, M, Gunst, J D, Søgaard, O S, O'Brien, T R, Tolstrup, M & Hartmann, R 2021, ' The Impact of IFNλ4 on the Adaptive Immune Response to SARS-CoV-2 Infection ', Journal of Interferon & Cytokine Research, vol. 41, no. 11, pp. 407-414 . https://doi.org/10.1089/jir.2021.0106
J Interferon Cytokine Res
Møhlenberg, M, Monrad, I, Vibholm, L K, Nielsen, S S F, Frattari, G S, Schleimann, M H, Olesen, R, Kjolby, M, Gunst, J D, Søgaard, O S, O'Brien, T R, Tolstrup, M & Hartmann, R 2021, ' The Impact of IFNλ4 on the Adaptive Immune Response to SARS-CoV-2 Infection ', Journal of Interferon and Cytokine Research, vol. 41, no. 11, pp. 407-414 . https://doi.org/10.1089/jir.2021.0106
Genetic polymorphisms at the IFNL4 loci are known to influence the clinical outcome of several different infectious diseases. Best described is the association between the IFNL4 genotype and hepatitis C virus clearance. However, an influence of the I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbd5c74c21631c4acab331eea151b90
https://vbn.aau.dk/da/publications/b0e9df5a-d6fd-4e4c-a50e-ea6970a8ee34
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7
TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
Autor: Mohamed Abdel-Mohsen, Jacob D. Estes, Martin Tolstrup, Manuel Schmidt, Kathleen Busman-Sahay, Line K. Vibholm, Andrew V. Kossenkov, Kathrine Kjær, Rikke Olesen, Michel Bach Hellfritzsch, Paul W. Denton, Michael Nekorchuk, Leila B. Giron, Lars Østergaard, Maria Louise Kobberø, Chi Ngai Chan, Tine Engberg Damsgaard, Peter Ahlburg, Mariane H. Schleimann, Jens R. Nyengaard, Phillipp Schommers, Florian Klein, Burghardt Wittig, Kaja Zuwala, Frederik H. Rothemejer, Harsh Dweep, Ole Schmeltz Søgaard
Publikováno v: Schleimann, M H, Kobberø, M-L, Vibholm, L K, Kjær, K, Giron, L B, Busman-Sahay, K, Chan, C N, Nekorchuk, M, Schmidt, M, Wittig, B, Damsgaard, T E, Ahlburg, P, Hellfritzsch, M B, Zuwala, K, Rothemejer, F H, Olesen, R, Schommers, P, Klein, F, Dweep, H, Kossenkov, A, Nyengaard, J R, Estes, J D, Abdel-Mohsen, M, Østergaard, L, Tolstrup, M, Søgaard, O S & Denton, P W 2019, ' TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes ', EBioMedicine, vol. 45, pp. 328-340 . https://doi.org/10.1016/j.ebiom.2019.07.005
EBioMedicine
Background TLR9 agonists are being developed as immunotherapy against malignancies and infections. TLR9 is primarily expressed in B cells and plasmacytoid dendritic cells (pDCs). TLR9 signalling may be critically important for B cell activity in lymp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb90886f03eb60b2c74bf7f1b076a347
https://doi.org/10.1016/j.ebiom.2019.07.005
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8
SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity
Autor: Ida Monrad, Marie H. Pahus, Rune Hartmann, Ole Schmeltz Søgaard, Martin Tolstrup, Jesper Damsgaard Gunst, Christian Erikstrup, Giacomo S. Frattari, Rikke Olesen, Mariane H. Schleimann, Line K. Vibholm, Stine S F Nielsen, Lars Østergaard, Andreas Holleufer, Jesper F Højen
Publikováno v: Nielsen, S S F, Vibholm, L K, Johannsen, I M, Olesen, R, Frattari, G, Pahus, M H, Højen, J F, Damsgaard Gunst, J, Erikstrup, C, Holleufer, A, Hartmann, R, Østergaard, L J, Søgaard, O S, Schleimann, M H & Tolstrup, M 2021, ' SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity ', EBioMedicine, vol. 68, 103410 . https://doi.org/10.1016/j.ebiom.2021.103410
EBioMedicine
EBioMedicine, Vol 68, Iss, Pp 103410-(2021)
Background: The SARS-CoV-2 pandemic currently prevails worldwide. To understand the immunological signature of SARS-CoV-2 infections and aid the search and evaluation of new treatment modalities and vaccines, comprehensive characterization of adaptiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b98eaf4d593544cae2c6e1c0759fba
https://pure.au.dk/portal/da/publications/sarscov2-elicits-robust-adaptive-immune-responses-regardless-of-disease-severity(c3f947ab-2a8b-4233-bf4c-902b6b2de478).html
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9
Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution
Autor: Mariane H. Schleimann, Louise Ørnskov Pedersen, Martin Tolstrup, Merete Storgaard, Line K. Vibholm, Ida Monrad, Mikkel Steen Petersen, Irene Harder Tarpgaard, Carl Mathias Kobel, Signe Risgaard Sahlertz, Stine Sofie Frank Nielsen, Klaus Leth Mortensen
Publikováno v: Open Forum Infectious Diseases
Monrad, I, Sahlertz, S R, Nielsen, S S F, Pedersen, L Ø, Petersen, M S, Kobel, C M, Tarpgaard, I H, Storgaard, M, Mortensen, K L, Schleimann, M H, Tolstrup, M & Vibholm, L K 2021, ' Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution ', Open Forum Infectious Diseases, vol. 8, no. 7, ofab295 . https://doi.org/10.1093/ofid/ofab295
We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95822770b6ca40480c1e8939f5e7640e
https://pubmed.ncbi.nlm.nih.gov/34258320
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