Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction

Autor: Marta S. Alexdottir, Martin Pehrsson, Viktor Domislovic, Line E. Godskesen, Aleksander Krag, Jens Kjeldsen, Marko Brinar, Ana Barisic, Anne-Christine Bay-Jensen, Morten A. Karsdal, Zeljko Krznaric, Joachim H. Mortensen

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Neutrophils play a significant role in sustaining chronic inflammation in Inflammatory Bowel Disease. The intestinal basement membrane acts as a barrier for immunological homeostasis, where the α3 and α4 chains of type IV collagen are expr

Externí odkaz: https://doaj.org/article/36ce61ebf75c4f13b829c1c0aa30a870

Remote ischemic conditioning in active ulcerative colitis: An explorative randomized clinical trial

Autor: Jens Kjeldsen, Michael Schmidt, Yan Yan, Hans Erik Bøtker, Gunvor Iben Madsen, Thomas Ravn Lassen, Aleksander Krag, Michael M. Nielsen, Sara K. Tjønnfjord, Jørgen Kjems, Nichlas Riise Jespersen, Majken S. Siersbæk, Lars Grøntved, Line E. Godskesen

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Godskesen, L E, Lassen, T R, Jespersen, N R, Siersbæk, M, Yan, Y, Nielsen, M M, Tjønnfjord, S K, Grøntved, L, Madsen, G, Kjems, J, Bøtker, H E, Schmidt, M R, Krag, A & Kjeldsen, J 2020, ' Remote ischemic conditioning in active ulcerative colitis : An explorative randomized clinical trial ', Scientific Reports, vol. 10, 9537 . https://doi.org/10.1038/s41598-020-65692-9
Godskesen, L E, Lassen, T R, Jespersen, N R, Siersbæk, M, Yan, Y, Nielsen, M M, Tjønnfjord, S K, Grøntved, L, Madsen, G, Kjems, J, Bøtker, H E, Schmidt, M R, Krag, A & Kjeldsen, J 2020, ' Remote ischemic conditioning in active ulcerative colitis : An explorative randomized clinical trial ', Scientific Reports, vol. 10, no. 1, 9537 . https://doi.org/10.1038/s41598-020-65692-9

Remote ischemic conditioning (RIC) by repetitive brief periods of limb ischemia and reperfusion renders organs more resistant to ischemic injury. The protection is partly through down-regulation of the inflammatory response. Our aim was to investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d8ec0286dface8e1c2e5156714ab3f
http://link.springer.com/article/10.1038/s41598-020-65692-9

P165 Non-invasive biomarkers of type III collagen cross-linking reflects fibrolysis in patient with luminal CROHN’S DISEASE

Autor: Line E. Godskesen, M Asser Karsdal, J Høg Mortensen, Martin Pehrsson, Jens Kjeldsen, A.-C. Bay-Jensen, Aleksander Krag

Publikováno v: Journal of Crohn's and Colitis. 15:S241-S242

Background Type III collagen of the interstitial matrix is highly expressed in fibrotic tissue of Crohn’s disease (CD) and suggested to undergo remodelling during the characteristic deep tissue inflammation. Periods of inflammatory flares and remis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acc28e59e0e98d6698f502da642495b0
https://doi.org/10.1093/ecco-jcc/jjab076.292

Mo1160 SEROLOGICAL BIOMARKERS OF INTERSTITIAL MATRIX AND BASEMENT MEMBRANE REMODELLING CORRELATES THE MODIFIED MAYO ENDOSCOPIC SCORE (MMES) FOR ULCERATIVE COLITIS

Autor: Tina Manon-Jensen, J H Mortensen, Aleksander Krag, Majken Lindholm, Line E. Godskesen, Morten A. Karsdal, Jens Kjeldsen

Publikováno v: Gastroenterology. 158:S-807

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bd9c5c5da958881e2557f0818574e4e
https://doi.org/10.1016/s0016-5085(20)32701-3

P637 MMP-2 and -8 degraded and citrullinated-vimentin (VICM) correlates to disease activity in inflammatory bowel diseases

Autor: Jens Kjeldsen, Line E. Godskesen, J Høg Mortensen, Tina Manon-Jensen, M.A. Karsdal, Majken Lindholm, Aleksander Krag

Publikováno v: Journal of Crohn's and Colitis. 13:S436-S437

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88db25c77944d55cdd7d434b12f2e803
https://doi.org/10.1093/ecco-jcc/jjy222.761