Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Line Aas Mortensen"'
Autor:
Line Aas Mortensen, Helle C. Thiesson, Birgitte Tougaard, Martin Egfjord, Anne Sophie Lind Fischer, Claus Bistrup
Publikováno v:
BMC Nephrology, Vol 19, Iss 1, Pp 1-7 (2018)
Abstract Background Calcineurin inhibitor induced nephrotoxicity contributes to late allograft failure in kidney transplant patients. Evidence points towards aldosterone to play a role in the development of fibrosis in multiple organs. Animal studies
Externí odkaz:
https://doaj.org/article/1c49dc1a881842fcbedbe2baf4a73c0e
Autor:
Line Aas Mortensen, Anne Marie Svane, Mark Burton, Claus Bistrup, Helle Charlotte Thiesson, Niels Marcussen, Hans Christian Beck
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2371 (2020)
Renal transplantation is the preferred treatment of end stage renal disease, but allograft survival is limited by the development of interstitial fibrosis and tubular atrophy in response to various stimuli. Much effort has been put into identifying n
Externí odkaz:
https://doaj.org/article/b98d827b50704c6789553e443251082c
Publikováno v:
Frontiers in Medicine, Vol 4 (2017)
Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved short-term outcome. The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial fib
Externí odkaz:
https://doaj.org/article/070833611fdd4a55a7427bfbe5faf515
Autor:
Line Aas Mortensen, Bente Jespersen, Anne Sophie Lind Helligsø, Donata Cibulskyte-Ninkovic, Birgitte Godskesen Tougaard, Martin Egfjord, Lene Boesby, Niels Marcussen, Kirsten Madsen, Boye L Jensen, Inge Petersen, Claus Bistrup, Helle Charlotte Thiesson
Publikováno v:
Mortensen, L A, Jespersen, B, Helligsø, A S L, Cibulskyte-Ninkovic, D, Tougaard, B G, Egfjord, M, Boesby, L, Marcussen, N, Madsen, K, Jensen, B L, Petersen, I, Bistrup, C & Thiesson, H C 2022, ' FC 118: The Effect of Spironolactone on Calcineurin Inhibitor Induced Nephrotoxicity—The Spiren Trial ', Nephrology Dialysis Transplantation, vol. 37, no. Supplement 3, gfac124.003 . https://doi.org/10.1093/ndt/gfac124.003
BACKGROUND AND AIMS Improving long-term allograft survival has been a challenge for nephrologists for decades. A common feature in late allograft failure is progressive interstitial fibrosis and tubular atrophy.[1] Increasing evidence points towards
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2839dc1c80db5a9c006d8c40f18f27fa
https://pure.au.dk/portal/da/publications/fc-118-the-effect-of-spironolactone-on-calcineurin-inhibitor-induced-nephrotoxicitythe-spiren-trial(8d093cea-c290-4b9b-b66d-0ac51c3396e7).html
https://pure.au.dk/portal/da/publications/fc-118-the-effect-of-spironolactone-on-calcineurin-inhibitor-induced-nephrotoxicitythe-spiren-trial(8d093cea-c290-4b9b-b66d-0ac51c3396e7).html
Autor:
Gitte R. Hinrichs, Line Aas Mortensen
Publikováno v:
American journal of kidney diseases : the official journal of the National Kidney Foundation. 81(1)
Autor:
Line Aas Mortensen, Ib Abildgaard, Helle C. Thiesson, Boye L. Jensen, Sai Sindhu Thangaraj, Christina Stolzenburg Oxlund
Publikováno v:
Thangaraj, S S, Oxlund, C, Mortensen, L A, Thiesson, H, Abildgaard, I & Jensen, B 2021, ' DOES ALDOSTERONE VIA MINERALOCORTICOID RECEPTORS AND ENAC PROMOTE INTERLEUKIN-17 PRODUCTION IN LYMPHOCYTES? ', Journal of Hypertension, vol. 39, no. Suppl. 1, pp. E285 . https://doi.org/10.1097/01.hjh.0000747728.76560.15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7af149eb9d507cacd72a3745cda745
https://portal.findresearcher.sdu.dk/da/publications/019d6ef7-c84a-444a-b36f-2838e0e1d99e
https://portal.findresearcher.sdu.dk/da/publications/019d6ef7-c84a-444a-b36f-2838e0e1d99e
Publikováno v:
Mortensen, L A, Bistrup, C, Jensen, B L & Hinrichs, G R 2020, ' A mini-review of pharmacological strategies used to ameliorate polyuria associated with X-linked nephrogenic diabetes insipidus ', American journal of physiology. Renal physiology, vol. 319, no. 5, pp. F746-F753 . https://doi.org/10.1152/ajprenal.00339.2020
Nephrogenic diabetes insipidus (NDI) is characterized by renal resistance to the antidiuretic hormone arginine vasopressin (AVP), which leads to polyuria, plasma hyperosmolarity, polydipsia, and impaired quality of living. Inherited forms are caused
Publikováno v:
Kidney International Reports
Hinrichs, G R, Mortensen, L A, Bistrup, C, Dieperink, H H & Jensen, B L 2020, ' Treatment of Nephrogenic Diabetes Insipidus Patients With cGMP : Stimulating Drugs Does Not Mitigate Polyuria or Increase Urinary Concentrating Ability ', Kidney International Reports, vol. 5, no. 8, pp. 1319-1325 . https://doi.org/10.1016/j.ekir.2020.05.015
Hinrichs, G R, Mortensen, L A, Bistrup, C, Dieperink, H H & Jensen, B L 2020, ' Treatment of Nephrogenic Diabetes Insipidus Patients With cGMP : Stimulating Drugs Does Not Mitigate Polyuria or Increase Urinary Concentrating Ability ', Kidney International Reports, vol. 5, no. 8, pp. 1319-1325 . https://doi.org/10.1016/j.ekir.2020.05.015
Autor:
Niels Marcussen, Helle C. Thiesson, Anne Marie Svane, Mark Burton, Hans Christian Beck, Line Aas Mortensen, Claus Bistrup
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2371, p 2371 (2020)
Mortensen, L A, Svane, A M, Burton, M, Bistrup, C, Thiesson, H C, Marcussen, N & Beck, H C 2020, ' Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis-A Study in Renal Transplant Patients ', International Journal of Molecular Sciences, vol. 21, no. 7, 2371 . https://doi.org/10.3390/ijms21072371
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2371, p 2371 (2020)
Mortensen, L A, Svane, A M, Burton, M, Bistrup, C, Thiesson, H C, Marcussen, N & Beck, H C 2020, ' Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis-A Study in Renal Transplant Patients ', International Journal of Molecular Sciences, vol. 21, no. 7, 2371 . https://doi.org/10.3390/ijms21072371
Renal transplantation is the preferred treatment of end stage renal disease, but allograft survival is limited by the development of interstitial fibrosis and tubular atrophy in response to various stimuli. Much effort has been put into identifying n
Autor:
Mattias Carlström, Yaseelan Palarasah, Line Aas Mortensen, Craig E. Wheelock, Antonio Checa, Claus Bistrup, Else M. Bladbjerg, Helle C. Thiesson, Boye L. Jensen, Jane Stubbe
Publikováno v:
Mortensen, L A, Bistrup, C, Stubbe, J, Carlström, M, Checa, A, Wheelock, C E, Palarasah, Y, Bladbjerg, E M, Thiesson, H C & Jensen, B L 2019, ' Effect of spironolactone for 1 yr on endothelial function and vascular inflammation biomarkers in renal transplant recipients ', American Journal of Physiology: Renal Physiology, vol. 317, no. 3, pp. F529-F539 . https://doi.org/10.1152/ajprenal.00025.2019
Kidney transplantation is associated with increased cardiovascular risk. Endothelial dysfunction and vascular inflammation contribute to negative outcome. In experimental models, mineralocorticoid receptor antagonists improved endothelial function an