Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Line, Oste"'
Autor:
Stéphanie Lavazais, Manja Jargosch, Sonia Dupont, Frédéric Labéguère, Christel Menet, Catherine Jagerschmidt, Frenz Ohm, Laszlo Kupcsik, Isabelle Parent, Céline Cottereaux, Florence Marsais, Line Oste, An Van de Water, Thierry Christophe, Steve De Vos, Padraic Fallon, Felix Lauffer, Philippe Clément-Lacroix, Kilian Eyerich, Reginald Brys
Publikováno v:
Science Translational Medicine. 15
Innate immunity not only shapes the way epithelial barriers interpret environmental cues but also drives adaptive responses. Therefore, modulators of innate immune responses are expected to have high therapeutic potential across immune-mediated infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d1ddc3b64e21e46fda5864368a152e3
https://doi.org/10.1126/scitranslmed.abj3289
https://doi.org/10.1126/scitranslmed.abj3289
Autor:
Graeme Milligan, Luke Jonathan Alvey, Annick Hagers, Thierry Christophe, Emanuelle Wakselman, Luc Nelles, Line Oste, Steve De Vos, Ann Vandevelde, Katja Conrath, Laurent Saniere, Stephen Robert Fletcher, Laura Jenkins, Sandrine Le Tallec, D. Merciris, Pierre Deprez, Roland Blanque, C. Cottereaux, Romain Luc Marie Gosmini, Ellen van der Aar, Cécile da Costa, Sonia Dupont, Thi Thu Trang Mai, Vanessa Quenehen, Labeguere Frederic Gilbert, Philippe Clément-Lacroix, Florilène Soulas, Reginald Brys, Gregory John Robert Newsome, Nele Vandervoort, Amynata Tirera
Publikováno v:
Journal of Medicinal Chemistry. 63:13526-13545
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8f803bd9662806c89d70fe1a829f85
https://doi.org/10.1021/acs.jmedchem.0c00272
https://doi.org/10.1021/acs.jmedchem.0c00272
Autor:
Nicolas Triballeau, Bertrand Heckmann, Nicolas Houvenaghel, Tanja Poljak, F. Marsais, Adeline Marie Elise Palisse, Emanuelle Wakselman, Mario Smehil, Mia Jans, Kathleen Sonck, Monica Borgonovi, Denis Bucher, Sandy El Bkassiny, Javier Blanc, Beatrice Coornaert, Thierry Christophe, Philippe Pujuguet, Vatroslav Letfus, M. Auberval, Lola Lecru, Laurent Saniere, Inge Duys, Reginald Brys, Line Oste, Brigitte Allart, Alex Jaunet, Maxim De Wachter, Catherine Jagerschmidt, Koen Karel Jansen, Oscar Mammoliti, Ludovic Waeckel, Giovanni Tricarico, Christel Jeanne Marie Menet, Renata Rupčić
Publikováno v:
Journal of medicinal chemistry. 64(19)
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease. Current treatments only slow down disease progression, making new therapeutic strategies compelling. Increasing evidence suggests that S1P2 antagonists could be effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045dde34db98ae7f215ad12e45f175db
https://pubmed.ncbi.nlm.nih.gov/34581584
https://pubmed.ncbi.nlm.nih.gov/34581584
Autor:
Thierry Christophe, Nicolas Houvenaghel, Philippe Clément-Lacroix, Reginald Brys, Line Oste, Inge Duys, Emanuelle Wakselman, Bertrand Heckmann, Caroline Joannesse, Alex Jaunet, Adeline Marie Elise Palisse, Brigitte Allart, Laurent Saniere, Mia Jans, Monica Borgonovi, Sandy El Bkassiny, Oscar Mammoliti, Beatrice Coornaert, Christel Jeanne Marie Menet, Kathleen Sonck
Publikováno v:
Journal of medicinal chemistry. 64(9)
Mounting evidence from the literature suggests that blocking S1P2 receptor (S1PR2) signaling could be effective for the treatment of idiopathic pulmonary fibrosis (IPF). However, only a few antagonists have been so far disclosed. A chemical enablemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bf77a662664d4953efc380b9590624
https://pubmed.ncbi.nlm.nih.gov/33939425
https://pubmed.ncbi.nlm.nih.gov/33939425
Autor:
Frédéric, Labéguère, Sonia, Dupont, Luke, Alvey, Florilène, Soulas, Gregory, Newsome, Amynata, Tirera, Vanessa, Quenehen, Thi Thu Trang, Mai, Pierre, Deprez, Roland, Blanqué, Line, Oste, Sandrine, Le Tallec, Steve, De Vos, Annick, Hagers, Ann, Vandevelde, Luc, Nelles, Nele, Vandervoort, Katja, Conrath, Thierry, Christophe, Ellen, van der Aar, Emanuelle, Wakselman, Didier, Merciris, Céline, Cottereaux, Cécile, da Costa, Laurent, Saniere, Philippe, Clement-Lacroix, Laura, Jenkins, Graeme, Milligan, Stephen, Fletcher, Reginald, Brys, Romain, Gosmini
Publikováno v:
Journal of medicinal chemistry. 63(22)
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dca817b6050468a00027ab8ce9b149c4
https://pubmed.ncbi.nlm.nih.gov/32902984
https://pubmed.ncbi.nlm.nih.gov/32902984
Autor:
Elsa De Lemos, Vanessa Quenehen, Laëtitia Cherel, Nicolas Triballeau, Reginald Brys, Stéphane Beaumont, Florilène Soulas, Murielle Manioc, Thierry Christophe, Emanuelle Wakselman, Ellen van der Aar, Natacha Bienvenu, Christelle L’Ebraly, Luc Nelles, Line Oste, Laurent Saniere, Fatoumata Djata, Stéphanie Lavazais, Philippe Delerive, Stephen Robert Fletcher, Steve De Vos, Mathieu Rafaël Pizzonero, Sabrina Kopiejewski, S. Dupont, Nick Vandeghinste, Jean-Michel Lefrancois, Benedetta Crescenzi, Denis Polancec, Marielle Babel, Pierre Deprez, Roland Blanque
Publikováno v:
Journal of Medicinal Chemistry. 57:10044-10057
FFA2, also called GPR43, is a G-protein coupled receptor for short chain fatty acids which is involved in the mediation of inflammatory responses. A class of azetidines was developed as potent FFA2 antagonists. Multiparametric optimization of early h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33097c7d0222ebea1a74983132fa64b7
https://doi.org/10.1021/jm5012885
https://doi.org/10.1021/jm5012885
Autor:
Nele Vandervoort, Xavier Marie Bock, Patrick Mollat, Jovica Ralić, Alain Monjardet, Nicolas Triballeau, Thierry Christophe, Ellen van der Aar, Marieke Lamers, Boska Hrvacic, Nicolas Desroy, Bertrand Heckmann, Line Oste, Emilie Rondet, Virginie Labeguere, Roland Blanque, Veronique Roncoroni, Christopher Gaëtan Housseman, Sandrine Le Tallec, Natacha Bienvenu, C. Cottereaux, M. Auberval, Reginald Brys, Laëtitia Cherel, Emanuelle Wakselman, Picolet Olivier Laurent, Jean-Marie Grassot, Agnès Marie Joncour, Christophe Peixoto, Denis Annoot
Autotaxin is a circulating enzyme with a major role in the production of lysophosphatic acid (LPA) species in blood. A role for the autotaxin/LPA axis has been suggested in many disease areas including pulmonary fibrosis. Structural modifications of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c6f6e80895c7ca93e77aad9243c383
https://www.bib.irb.hr/981523
https://www.bib.irb.hr/981523
Autor:
Alejandra Leticia Walder, M. E. De Broe, Ludwig V. Lamberts, Geert J. Behets, Walter E. Cabrera, F. Santa Cruz, An R.J. Bervoets, Line Oste, Susana Barreto, Patrick C. D'Haese, Steven C. Verberckmoes
Publikováno v:
Trace Elements and Electrolytes. 25:92-99
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e1c2b53536ef3cc41a3c4585ea085a6
https://doi.org/10.5414/tep25092
https://doi.org/10.5414/tep25092
Autor:
Sylvain Bohic, Geert Dams, Patrick C. D'Haese, Steven C. Verberckmoes, Marc E. De Broe, An R. Bervoets, Michael Drakopoulos, Viviane Van Hoof, Geert J. Behets, Line Oste
Publikováno v:
X-ray spectrometry
We previously demonstrated the development of a mineralization defect during strontium administration and its reversibility after withdrawal in rats with chronic renal failure. Recently, strontium ranelate has been introduced as a therapeutic agent f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c710d303e8aa1fb595e0f1e7767b3f10
https://doi.org/10.1002/xrs.929
https://doi.org/10.1002/xrs.929
Autor:
Steven C. Verberckmoes, John Denton, Murielle Salomé, Alan G. Cox, Patrick C. D'Haese, An R. Bervoets, Marc E. De Broe, Geert J. Behets, Line Oste
Publikováno v:
Kidney International. 67:1830-1836
Localization of lanthanum in bone of chronic renal failure rats after oral dosing with lanthanum carbonate. Background Lanthanum carbonate has been shown to be a safe, effective phosphate-binding agent. We have shown that an impaired mineralization i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839f372aa9a93fcb2b6ff61781ffaf21
https://doi.org/10.1111/j.1523-1755.2005.00281.x
https://doi.org/10.1111/j.1523-1755.2005.00281.x