Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lindy K. Alles"'
Autor:
Thomas F. Eleveld, Lindy Vernooij, Linda Schild, Bianca Koopmans, Lindy K. Alles, Marli E. Ebus, Rana Dandis, Harm van Tinteren, Huib N. Caron, Jan Koster, Max M. van Noesel, Godelieve A. M. Tytgat, Selma Eising, Rogier Versteeg, M. Emmy M. Dolman, Jan J. Molenaar
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionMutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition in vitro. However, these inhibitors alone do not lead to tumor regression in vivo, indicating th
Externí odkaz:
https://doaj.org/article/f113f91a5d74419a8ac27a8cd36776b9
Autor:
M. Emmy M. Dolman, Jan J. Molenaar, Kelly C. Goldsmith, Jan Koster, Ronald W. Stam, Mark Kerstjens, David A. Egan, Daphne Lelieveld, Linda Schild, Nil A. Schubert, Hunter C. Jonus, Bianca Koopmans, Jasmine Y. Lee, Lindy K. Alles, Laurel T. Bate-Eya, Lindy Vernooij
Supplementary data including supplementary figures S1 to S6 and supplementary tables S1 to S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c19a6188349cc1e7ae304543adf5a25
https://doi.org/10.1158/1535-7163.22522524
https://doi.org/10.1158/1535-7163.22522524
Autor:
M. Emmy M. Dolman, Jan J. Molenaar, Kelly C. Goldsmith, Jan Koster, Ronald W. Stam, Mark Kerstjens, David A. Egan, Daphne Lelieveld, Linda Schild, Nil A. Schubert, Hunter C. Jonus, Bianca Koopmans, Jasmine Y. Lee, Lindy K. Alles, Laurel T. Bate-Eya, Lindy Vernooij
Supplementary information on the used materials and methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737308f3d4a0e5a27d921f6744ac9ebf
https://doi.org/10.1158/1535-7163.22522521.v1
https://doi.org/10.1158/1535-7163.22522521.v1
Autor:
M. Emmy M. Dolman, Jan J. Molenaar, Kelly C. Goldsmith, Jan Koster, Ronald W. Stam, Mark Kerstjens, David A. Egan, Daphne Lelieveld, Linda Schild, Nil A. Schubert, Hunter C. Jonus, Bianca Koopmans, Jasmine Y. Lee, Lindy K. Alles, Laurel T. Bate-Eya, Lindy Vernooij
Neuroblastoma tumors frequently overexpress the anti-apoptotic protein B-cell lymphoma/leukemia 2 (BCL-2). We previously showed that treating BCL-2–dependent neuroblastoma cells with the BCL-2 inhibitor venetoclax results in apoptosis, but unfortun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94290ce21ef15de16b10560ee4307a2
https://doi.org/10.1158/1535-7163.c.6543414.v1
https://doi.org/10.1158/1535-7163.c.6543414.v1
Autor:
Jan J. Molenaar, Rogier Versteeg, Peter van Sluis, Godelieve A. Tijtgat, Richard Volckmann, Marli E. Ebus, Lindy K. Alles, Danny A. Zwijnenburg, Jan Koster, Linda Schild, Thomas F. Eleveld
Supplementary Figure 1: RAS-MAPK activation on the protein level is related to mutation status, Supplementary Figure 2: Differentially expressed genes between the experimental systems used for signature generation, Supplementary Figure 3: Differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e718a10555b73e881a86011be4e3361
https://doi.org/10.1158/0008-5472.22419947
https://doi.org/10.1158/0008-5472.22419947
Autor:
Jan J. Molenaar, Rogier Versteeg, Peter van Sluis, Godelieve A. Tijtgat, Richard Volckmann, Marli E. Ebus, Lindy K. Alles, Danny A. Zwijnenburg, Jan Koster, Linda Schild, Thomas F. Eleveld
Mutations affecting the RAS–MAPK pathway frequently occur in relapsed neuroblastoma tumors, which suggests that activation of this pathway is associated with a more aggressive phenotype. To explore this hypothesis, we generated several model system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf93e63bcd3155267314d8a3b712bd87
https://doi.org/10.1158/0008-5472.c.6510512.v1
https://doi.org/10.1158/0008-5472.c.6510512.v1
Autor:
Jan J. Molenaar, Rogier Versteeg, Peter van Sluis, Godelieve A. Tijtgat, Richard Volckmann, Marli E. Ebus, Lindy K. Alles, Danny A. Zwijnenburg, Jan Koster, Linda Schild, Thomas F. Eleveld
Supplementary Table 1: Public datasets used in this study, Supplementary Table 2: gRNA sequences against CIC, NF1 and DMD, Supplementary Table 3: Primers used for RT-qPCR experiments, Supplementary Table 4: Genes differentially expressed in the vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2902dbfd3ed8764d32c6a2e651870f
https://doi.org/10.1158/0008-5472.22419944.v1
https://doi.org/10.1158/0008-5472.22419944.v1
Autor:
Thomas F. Eleveld, Lindy Vernooij, Linda Schild, Bianca Koopmans, Lindy K. Alles, Marli E. Ebus, Rana Dandis, Harm van Tinteren, Huib N. Caron, Jan Koster, Max M. van Noesel, Godelieve A. M. Tytgat, Selma Eising, Rogier Versteeg, M. Emmy M. Dolman, Jan J. Molenaar
Publikováno v:
SSRN Electronic Journal.
IntroductionMutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition in vitro. However, these inhibitors alone do not lead to tumor regression in vivo, indicating th
Autor:
Michal Heger, Lindy K. Alles, Dirk R. de Waart, Megan J. Reiniers, Bulent Ergin, Adrie Maas, Thomas M. van Gulik, Pim B. Olthof, Steven W.M. Olde Damink, Frank G. Schaap, Joanne Verheij, Rowan F. van Golen, Lianne R. de Haan, Daniël A. Lionarons, Peter L.M. Jansen, Zehra Uz
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific reports, 8(1). Nature Publishing Group
Scientific Reports
Scientific Reports, 8:16529. Nature Publishing Group
Scientific reports, 8(1). Nature Publishing Group
Scientific Reports
Scientific Reports, 8:16529. Nature Publishing Group
Cholestasis impairs liver regeneration following partial liver resection (PHx). Bile acid receptor farnesoid X-receptor (FXR) is a key mediator of liver regeneration. The effects of FXR agonist obeticholic acid (OCA) on liver (re)growth were therefor
Autor:
Bianca Koopmans, Thomas F. Eleveld, Lindy Vernooij, Rogier Versteeg, Emmy Dolman, Huib N. Caron, Marli E. Ebus, Jan Koster, Lindy K. Alles, Peter van Sluis, Linda Schild, Jan J. Molenaar
Mutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition in vitro. However, these inhibitors alone do not lead to tumor regression in vivo, indicating the need for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a149c61ba3deceda7fd2cabb881ad8a7
https://doi.org/10.1101/2020.02.12.945089
https://doi.org/10.1101/2020.02.12.945089