Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Lindy G Durrant"'
Autor:
Ian Pike, Victoria A Brentville, Peter Symonds, Katherine W Cook, Lindy G Durrant, Sabaria Shah, Samantha J Paston, Juliane Weißer, Anne Skinner, Abdullah Al Omari
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background Post-translational modification of proteins has the potential to alter the ability of T cells to recognize major histocompatibility complex (MHC) class -I and class-II restricted antigens, thereby resulting in altered immune responses. One
Externí odkaz:
https://doaj.org/article/342d5a87314b4e2e86c9b1772995e11a
Autor:
Wilko Weichert, Lei Cai, Soldano Ferrone, Peter J K Kuppen, Lindy G Durrant, Theodoros Michelakos, Filippos Kontos, Tomohiro Kurokawa, Ananthan Sadagopan, Danielle Krijgsman, Cristina R Ferrone
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Purpose The association of human leucocyte antigen (HLA) class I expression levels with the clinical course of many malignancies reflects their crucial role in the recognition and elimination of malignant cells by cognate T cells and NK cells. In col
Externí odkaz:
https://doaj.org/article/e7b9bb0a184e4674bba2e19cb5b513a1
Autor:
Victoria A Brentville, Rachael L Metheringham, Ian Daniels, Peter Symonds, Katherine W Cook, Mohamed Gijon, Lindy G Durrant, Ruhul H Choudhury, Samantha J Paston
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/2b8c7865e85b450a842ca77fb4634bb2
Autor:
Wei Xue, Victoria A Brentville, Rachael L Metheringham, Ian Daniels, Suha Atabani, Peter Symonds, Katherine W Cook, Poonam Vaghela, Mohamed Gijon, Lindy G Durrant, David Boocock, Clare Coveney, Amanda K Miles, Sabaria Shah, Ruhul H Choudhury, Daisy Weston
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Homocitrullination is the post-translational modification of lysine that is recognized by T cells.Methods This study identified homocitrullinated peptides from aldolase, enolase, cytokeratin and binding immunoglobulin protein and used huma
Externí odkaz:
https://doaj.org/article/8304c7bef9614211b835d19438adf38c
Autor:
Victoria A Brentville, Rachael L Metheringham, Ian Daniels, Suha Atabani, Peter Symonds, Katherine W Cook, Mireille Vankemmelbeke, Ruhul Choudhury, Poonam Vaghela, Mohamed Gijon, Ghislaine Meiners, Willem-Jan Krebber, Cornelis J M Melief, Lindy G Durrant
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Stress-induced post-translational modifications occur during autophagy and can result in generation of new epitopes and immune recognition. One such modification is the conversion of arginine to citrulline by peptidylarginine deiminase enz
Externí odkaz:
https://doaj.org/article/646c4a138fd4417ea278c37406bd14b0
Autor:
Victoria A Brentville, Peter Symonds, Katherine W Cook, Ian Daniels, Tracy Pitt, Mohamed Gijon, Poonam Vaghela, Wei Xue, Sabaria Shah, Rachael L Metheringham, Lindy G Durrant
Publikováno v:
OncoImmunology, Vol 8, Iss 5 (2019)
Post-translational modifications are induced in stressed cells which cause them to be recognised by the system. One such modification is citrullination where the positive charged arginine is modified to a neutral citrulline. We demonstrate most healt
Externí odkaz:
https://doaj.org/article/50f7794fe18c404f878327e37bf15e3e
Publikováno v:
Therapeutic Advances in Vaccines and Immunotherapy, Vol 6 (2018)
The interplay between tumours and the immune system has long been known to involve complex interactions between tumour cells, immune cells and the tumour microenvironment. The progress of checkpoint inhibitors in the clinic in the last decade has hig
Externí odkaz:
https://doaj.org/article/8b28200a1ac04316aa1c7e872dc301a1
Autor:
Daniel Sijmons, Simon Collett, Caroline Soliman, Andrew J. Guy, Andrew M. Scott, Lindy G. Durrant, Aaron Elbourne, Anna K. Walduck, Paul A. Ramsland
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Helicobacter pylori infects approximately half the human population and has an unusual infective niche of the human stomach. Helicobacter pylori is a major cause of gastritis and has been classified as a group 1 carcinogen by the WHO. Treatm
Externí odkaz:
https://doaj.org/article/75bc18832d0d46148c4f0a53f0ca2a25
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54892 (2013)
Several monoclonal antibodies (mAbs) recognising Lewis(y), such as BR96, have reached the clinic but have failed to show good anti-tumour responses with an acceptable level of toxicity. No Lewis(b) mAbs have been trialled in patients. In this study w
Externí odkaz:
https://doaj.org/article/caf89600bef145b39f592b886d8c3fa4
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41112 (2012)
High avidity cytotoxic T lymphocytes (CTL) are important in viral clearance and anti-tumor immunity, however, mechanisms for their optimal generation and maintenance in vivo remain unclear. Immunizing mice with an antibody-DNA vaccine encoding a sing
Externí odkaz:
https://doaj.org/article/c741535a40d54792b6ddb378437fcf2b