Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

Autor: Francesca Rapino, Ted Natoli, Francesco Limone, Erin O’Connor, Jack Blank, Matthew Tegtmeyer, William Chen, Erika Norabuena, Juhi Narula, Dane Hazelbaker, Gabriella Angelini, Lindy Barrett, Alison O’Neil, Ursula K. Beattie, Jessica M. Thanos, Heather de Rivera, Steven D. Sheridan, Roy H. Perlis, Steven A. McCarroll, Beth Stevens, Aravind Subramanian, Ralda Nehme, Lee L. Rubin

Publikováno v: Stem Cell Reports, Vol 18, Iss 1, Pp 237-253 (2023)

Summary: In the brain, the complement system plays a crucial role in the immune response and in synaptic elimination during normal development and disease. Here, we sought to identify pathways that modulate the production of complement component 4 (C

Externí odkaz: https://doaj.org/article/660be2f0da164413bfeab8d8ecac144d

Autism genes converge on asynchronous development of shared neuron classes

Autor: Bruna Paulsen, Silvia Velasco, Amanda J. Kedaigle, Martina Pigoni, Giorgia Quadrato, Anthony J. Deo, Xian Adiconis, Ana Uzquiano, Rafaela Sartore, Sung Min Yang, Sean K. Simmons, Panagiotis Symvoulidis, Kwanho Kim, Kalliopi Tsafou, Archana Podury, Catherine Abbate, Ashley Tucewicz, Samantha N. Smith, Alexandre Albanese, Lindy Barrett, Neville E. Sanjana, Xi Shi, Kwanghun Chung, Kasper Lage, Edward S. Boyden, Aviv Regev, Joshua Z. Levin, Paola Arlotta

Publikováno v: Nature. 602:268-273

Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes spanning a wide range of biological functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd53e57f536ce5e648278370de37b1d
https://doi.org/10.1038/s41586-021-04358-6

Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma

Autor: Dolores Hambardzumyan, Courtney Coker, Zvi Granot, Lindy Barrett, Eric C. Holland, Hyung song Nam, Antonio Iavarone, Robert Benezra

Publikováno v: Cancer Cell. 21:11-24

Within high-grade gliomas, the precise identities and functional roles of stem-like cells remain unclear. In the normal neurogenic niche, ID (Inhibitor of DNA-binding) genes maintain self-renewal and multipotency of adult neural stem cells. Using PDG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2dc45504a7fc872693574db8cdd44e
https://doi.org/10.1016/j.ccr.2011.11.025

A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases

Autor: Tae Kyung Kim, James M. Powers, Howard J. Federoff, Lindy Barrett, Min-Sun Kim, James Eberwine, Jai-Yoon Sul, Anup Sharma, Linda M. Callahan

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 2, p e9002 (2010)
Sharma, A; Callahan, LM; Sul, JY; Kim, TK; Barrett, L; Kim, M; et al.(2010). A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. PLoS ONE, 5(2). doi: 10.1371/journal.pone.0009002. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5zb1848p

Neurodegenerative diseases are characterized by a number of features including the formation of inclusions, early synaptic degeneration and the selective loss of neurons. Molecules serving as links between these shared features have yet to be identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c8c3b0704062578f252f84a38ba0de
https://pubmed.ncbi.nlm.nih.gov/20126313