Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Lindy Holden-Dye"'
Autor:
Patricia G Izquierdo, Claude L Charvet, Cedric Neveu, A Christopher Green, John E H Tattersall, Lindy Holden-Dye, Vincent O'Connor
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284786 (2023)
Organophosphate intoxication via acetylcholinesterase inhibition executes neurotoxicity via hyper stimulation of acetylcholine receptors. Here, we use the organophosphate paraoxon-ethyl to treat C. elegans and use its impact on pharyngeal pumping as
Externí odkaz:
https://doaj.org/article/4f9d60c94fb44e47b32f26d841109694
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 1240-1247 (2021)
Caenorhabditis elegans provides a multi-cellular model organism for toxicology and drug discovery. These studies usually require solvents such as dimethyl sulfoxide (DMSO), ethanol or acetone as a vehicle. This raises the need to carefully consider w
Externí odkaz:
https://doaj.org/article/7c9120f1ab234502bead2f7cba4c413d
Autor:
Helena Rawsthorne-Manning, Fernando Calahorro, Patricia G Izquierdo, Philippe Tardy, Thomas Boulin, Lindy Holden-Dye, Vincent O'Connor, James Dillon
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0253351 (2022)
Multiple advances have been made to increase the efficiency of CRISPR/Cas9 editing using the model genetic organism Caenorhabditis elegans (C. elegans). Here we report on the use of co-CRISPR 'marker' genes: worms in which co-CRISPR events have occur
Externí odkaz:
https://doaj.org/article/70420065186b41fbab991226b474e90a
Autor:
Jürgen Krücken, Lindy Holden-Dye, Jennifer Keiser, Roger K Prichard, Simon Townson, Benjamin L Makepeace, Marc P Hübner, Steffen R Hahnel, Ivan Scandale, Achim Harder, Daniel Kulke
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009682 (2021)
Current mass drug administration (MDA) programs for the treatment of human river blindness (onchocerciasis) caused by the filarial worm Onchocerca volvulus rely on ivermectin, an anthelmintic originally developed for animal health. These treatments a
Externí odkaz:
https://doaj.org/article/869be43936bd408ea70f27f4bdab6d28
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0243121 (2021)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by a triad of behavioural impairments and includes disruption in social behaviour. ASD has a clear genetic underpinning and hundreds of genes are implicated in its aetiolog
Externí odkaz:
https://doaj.org/article/4743f573454a4684a740f1606a705510
Autor:
Anna Crisford, Fernando Calahorro, Elizabeth Ludlow, Jessica M C Marvin, Jennifer K Hibbard, Catherine J Lilley, James Kearn, Francesca Keefe, Peter Johnson, Rachael Harmer, Peter E Urwin, Vincent O'Connor, Lindy Holden-Dye
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008884 (2020)
Plant parasitic nematodes are microscopic pathogens that invade plant roots and cause extensive damage to crops. We have used a chemical biology approach to define mechanisms underpinning their parasitic behaviour: We discovered that reserpine, a pla
Externí odkaz:
https://doaj.org/article/84ff127a5f3b4b3187789fa0da972802
Publikováno v:
Frontiers in Microbiology, Vol 10 (2020)
In its native environment of rotting vegetation, the soil nematode Caenorhabditis elegans encounters a range of bacteria. This includes species from the ESKAPE group of pathogens that pose a clinical problem in acquired hospital infections. Here, we
Externí odkaz:
https://doaj.org/article/00c9a4a0d2a24e6fb962cb811313192c
Autor:
Lindy Holden-Dye, Giovanna Ponte, A. Louise Allcock, Erica A. G. Vidal, Ryuta Nakajima, Tarla Rai Peterson, Graziano Fiorito
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/a01c43f9f578495180145963396e464d
Autor:
Alexandra Blanchard, Fabrice Guégnard, Claude L Charvet, Anna Crisford, Elise Courtot, Christine Sauvé, Abdallah Harmache, Thomas Duguet, Vincent O'Connor, Philippe Castagnone-Sereno, Barbara Reaves, Adrian J Wolstenholme, Robin N Beech, Lindy Holden-Dye, Cedric Neveu
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1006996 (2018)
Cholinergic agonists such as levamisole and pyrantel are widely used as anthelmintics to treat parasitic nematode infestations. These drugs elicit spastic paralysis by activating acetylcholine receptors (AChRs) expressed in nematode body wall muscles
Externí odkaz:
https://doaj.org/article/28410ae1fb11412eb1de52ffddf3d9f6
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 1240-1247 (2021)
Toxicology Reports, Vol 8, Iss, Pp 1240-1247 (2021)
Graphical abstract
Highlights • DMSO impacts on C. elegans feeding behaviour in short-term and in a reversible manner. • DMSO affects the cellular integrity of C. elegans. • nlg-1 mutant is refractory to DMSO induced pumping inhibition.
Highlights • DMSO impacts on C. elegans feeding behaviour in short-term and in a reversible manner. • DMSO affects the cellular integrity of C. elegans. • nlg-1 mutant is refractory to DMSO induced pumping inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2ffbd0ba969c5936b6cf8a6c6c10e0
http://europepmc.org/articles/PMC8233170
http://europepmc.org/articles/PMC8233170