Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea.

Autor: Jianxing Zhang, Xiaoyu Xu, Narayanam V Rao, Brian Argyle, Lindsi McCoard, William J Rusho, Thomas P Kennedy, Glenn D Prestwich, Gerald Krueger

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e16658 (2011)

Rosacea is a common disfiguring skin disease of primarily Caucasians characterized by central erythema of the face, with telangiectatic blood vessels, papules and pustules, and can produce skin thickening, especially on the nose of men, creating rhin

Externí odkaz: https://doaj.org/article/66cb7a2b996f4befaeaaf8e2803a99e3

Photocrosslinkable Hyaluronan-Gelatin Hydrogels for Two-Step Bioprinting

Autor: Siam Oottamasathien, Jianxing Zhang, Aleksander Skardal, Lindsi McCoard, Glenn D. Prestwich, Xiaoyu Xu

Publikováno v: Tissue Engineering Part A. 16:2675-2685

Bioprinting by the codeposition of cells and biomaterials is constrained by the availability of printable materials. Herein we describe a novel macromonomer, a new two-step photocrosslinking strategy, and the use of a simple rapid prototyping system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138c02e0eb4ac7e156e3ef2208382b73
https://doi.org/10.1089/ten.tea.2009.0798

A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides

Autor: Jianxing Zhang, Aleksander Skardal, Sean Slack, Randal O. Dull, Lindsi McCoard, Kathleen M. Job, Glenn D. Prestwich, Thomas P. Kennedy, Siam Oottamasathien, Wanjian Jia

Publikováno v: The Journal of urology. 186

Studies show that LL-37 is a naturally occurring urinary defensin peptide that is up-regulated during urinary tract infections. Although normal urinary LL-37 levels are antimicrobial, we propose that increased LL-37 may trigger bladder inflammation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4ce41f43e2ba2e4388cfe0dc3df9a0
https://pubmed.ncbi.nlm.nih.gov/21855919

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LL-37 induced cystitis and the receptor for advanced glycation end-products (RAGE) pathway.

Autor: Roundy LM; Department of Surgery and Division of Pediatric Urology: Primary Children's Medical Center, Salt Lake City, Utah., Jia W; Department of Surgery and Division of Pediatric Urology: Primary Children's Medical Center, Salt Lake City, Utah., Zhang J; Department of Medicinal Chemistry and Center for Therapeutic Biomaterials: University of Utah, Salt Lake City, Utah., Ye X; Department of Pharmacotherapy: Primary Children's Medical Center, University of Utah, Salt Lake City, Utah., Prestwich GD; Department of Medicinal Chemistry and Center for Therapeutic Biomaterials: University of Utah, Salt Lake City, Utah., Oottamasathien S; Department of Surgery and Division of Pediatric Urology: Primary Children's Medical Center, Salt Lake City, Utah.

Publikováno v: Advances in bioscience and biotechnology (Print) [Adv Biosci Biotechnol] 2013 Aug 01; Vol. 4 (8B), pp. 1-8.