Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Lindsey T. Brinton"'
Autor:
Jessica Hung, Samantha M. Perez, Siva Sai Krishna Dasa, Sarah P. Hall, Danielle B. Heckert, Brian P. Murphy, Howard C. Crawford, Kimberly A. Kelly, Lindsey T. Brinton
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 389 (2023)
Cancer-associated fibroblasts (CAFs) execute diverse and complex functions in cancer progression. While reprogramming the crosstalk between CAFs and cancer epithelial cells is a promising avenue to evade the adverse effects of stromal depletion, drug
Externí odkaz:
https://doaj.org/article/8b6941c6992440c093636b73ca263b74
Autor:
Lindsey T. Brinton, Pu Zhang, Katie Williams, Daniel Canfield, Shelley Orwick, Steven Sher, Ronni Wasmuth, Larry Beaver, Casey Cempre, Jordan Skinner, Matthew Cannon, Mukul Govande, Bonnie Harrington, Amy Lehman, John C. Byrd, Rosa Lapalombella, James S. Blachly
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-10 (2020)
Abstract Acute myeloid leukemia (AML) is a heterogeneous and complex disease, and treatments for this disease have not been curative for the majority of patients. In younger patients, internal tandem duplication of FLT3 (FLT3-ITD) is a common mutatio
Externí odkaz:
https://doaj.org/article/f9792135e55a4ec59d467892727b81d0
Autor:
Jae Yoon Jeon, Daelynn R. Buelow, Dominique A. Garrison, Mingshan Niu, Eric D. Eisenmann, Kevin M. Huang, Megan E. Zavorka Thomas, Robert H. Weber, Clifford J. Whatcott, Steve L. Warner, Shelley J. Orwick, Bridget Carmichael, Emily Stahl, Lindsey T. Brinton, Rosa Lapalombella, James S. Blachly, Erin Hertlein, John C. Byrd, Bhavana Bhatnagar, Sharyn D. Baker
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
Effective treatment for AML is challenging due to the presence of clonal heterogeneity and the evolution of polyclonal drug resistance. Here, we report that TP-0903 has potent activity against protein kinases related to STAT, AKT, and ERK signaling,
Externí odkaz:
https://doaj.org/article/4bacc087740b4a43a3e2e850f46e9e4b
Publikováno v:
Cells, Vol 10, Iss 9, p 2246 (2021)
The cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various cellular activities contributing to tumorigenesis, including cancer cell proliferation, adh
Externí odkaz:
https://doaj.org/article/64a951f22aba41bf937549d896734664
Autor:
Anant A. Agrawal, Michael Seiler, Lindsey T. Brinton, Rose Mantel, Rosa Lapalombella, Jennifer A. Woyach, Amy J. Johnson, Ping Zhu, Markus Warmuth, Lihua Yu, John C. Byrd, Peter G. Smith, James S. Blachly, Silvia Buonamici
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 995-1000 (2017)
Externí odkaz:
https://doaj.org/article/b8e285b935314e6fbf1de8e2ffe50316
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Knockdown of selected genes has modest effects on MOLM13 responses to KPT-9274 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e089686f0f043cf55ed77ea029b663
https://doi.org/10.1158/1078-0432.22484258.v1
https://doi.org/10.1158/1078-0432.22484258.v1
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Purpose:Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors (NAMPTi) are currently in development, but may be limited as single-agent therapy due to compound-specific toxicity and cancer metabolic plasticity allowing resistance development. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb93244d92585ade19bc491075e0227
https://doi.org/10.1158/1078-0432.c.6531362.v1
https://doi.org/10.1158/1078-0432.c.6531362.v1
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f97f72a1132c12ed8622df6bb0ae38
https://doi.org/10.1158/1078-0432.22484240
https://doi.org/10.1158/1078-0432.22484240
Autor:
Jae Yoon Jeon, Alice A. Gibson, Alex Sparreboom, Xiyuan Lu, Alessia Lodi, Julie Nguyen, Sharyn D. Baker, Meghan Collins, Douglas H. Sweet, Zahra Talebi, Muhammad Erfan Uddin, Daelynn R. Buelow, Rosa Lapalombella, Shannon R. Sweeney, Moray J. Campbell, Stefano Tiziani, Megan E. Zavorka Thomas, Lindsey T. Brinton
Publikováno v:
Molecular Cancer Therapeutics. 20:2207-2217
Acute myeloid leukemia (AML) with an FLT3 internal tandem duplication (FLT3-ITD) mutation is an aggressive hematologic malignancy associated with frequent relapse and poor overall survival. The tyrosine kinase inhibitor gilteritinib is approved for t
Autor:
Pu, Zhang, Lindsey T, Brinton, Mehdi, Gharghabi, Steven, Sher, Katie, Williams, Matthew, Cannon, Janek S, Walker, Daniel, Canfield, Larry, Beaver, Casey B, Cempre, Hannah, Phillips, Xuyong, Chen, Pearlly, Yan, Amy, Lehman, Peggy, Scherle, Min, Wang, Kris, Vaddi, Robert, Baiocchi, Ruoning, Wang, Deepa, Sampath, Lapo, Alinari, James S, Blachly, Rosa, Lapalombella
Publikováno v:
Science advances. 8(37)
Using a genome-wide CRISPR screen, we identified