Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lindsey O. Webster"'
Autor:
Susan L Ford, Gary D Bowers, Lindsey O. Webster, Elizabeth P Gould, Joseph W. Polli, Melinda J. Reese, Joan E. Humphreys
Publikováno v:
Xenobiotica. 46:445-456
1. Cabotegravir (CAB; GSK1265744) is a potent HIV integrase inhibitor in clinical development as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. 2. This work investigated if CAB was a substrate for
Autor:
Paul M. Savina, Joseph W. Polli, Eri Kanaoka, Grant T. Generaux, James D. Clarke, Kelly A. Harmon, Helen Tracey, Melinda J. Reese, Joan E. Humphreys, Lindsey O. Webster
Publikováno v:
Drug Metabolism and Disposition. 41:353-361
Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require pharmacokinetic boosting. This work investigated the in vitro drug transport and metabolism
Autor:
Kim L. R. Brouwer, Joseph W. Polli, Grant T. Generaux, Sapana Vora, Kristina K. Wolf, Lindsey O. Webster
Publikováno v:
Toxicology in Vitro. 24:297-309
Hepatocellular accumulation of bile acids due to inhibition of the canalicular bile salt export pump (BSEP/ABCB11) is one proposed mechanism of drug-induced liver injury (DILI). Some hepatotoxic compounds also are potent inhibitors of bile acid uptak
Autor:
Cosette J. Serabjit-Singh, Jarkko Rautio, Lindsey O. Webster, Jeevan R. Kunta, Joseph W. Polli, John P. Keogh, Anand Balakrishnan, Joan E. Humphreys
Publikováno v:
Drug Metabolism and Disposition. 34:786-792
Because modulation of P-glycoprotein (Pgp) through inhibition or induction can lead to drug-drug interactions by altering intestinal, central nervous system, renal, or biliary efflux, it is anticipated that information regarding the potential interac
Autor:
Richard A. Graham, Edward L. LeCluyse, Philip Clark, Wojciech L. Krol, Liangfu Chen, Troy T. Banks, Lindsey O. Tyler, Ivin S. Silver, Lindsey O. Webster
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 20:69-78
Compared to other species, little information is available on the xenobiotic-induced regulation of cytochrome P450 enzymes in the beagle dog. Dogs are widely used in the pharmaceutical industry for many study types, including those that will impact d
Autor:
Robert J. Barnaby, Cosette J. Serabjit-Singh, Luigina Bertolotti, Joseph W. Polli, Todd M. Baughman, Joan E. Humphreys, Angela L. Mote, Giovanni Vitulli, Kevin D. Read, Lindsey O. Webster, Kelly H. Jordan
Publikováno v:
Drug Metabolism and Disposition. 32:722-726
This article is available online at http://dmd.aspetjournals.org ABSTRACT: GV196771 (E-4,6-dichloro-3-(2-oxo-1-phenyl-pyrrolidin-3-glyden- emethyl)-1H-indole-2 carboxylic acid) is a potent antagonist of the modulatory glycine site of the N-methyl-D-a
Autor:
Lindsey O. Webster, Larry J. Shampine, Kelly M. Mahar Doan, Cosette J. Serabjit-Singh, Joan E. Humphreys, Joseph W. Polli, Stephen A. Wring, Kimberly K. Adkison
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:1029-1037
Membrane permeability and P-glycoprotein (Pgp) can be limiting factors for blood-brain barrier penetration. The objectives of this study were to determine whether there are differences in the in vitro permeability, Pgp substrate profiles, and physico
Autor:
Maciej J. Zamek-Gliszczynski, Joseph W. Polli, Lindsey O. Webster, J. Cory Kalvass, Joan E. Humphreys, Keith Hoffmaster, Rong Zhao, Kim L. R. Brouwer, Arlene S. Bridges, Xianbin Tian
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 33(8)
Previous reports have demonstrated that sulfate metabolites may be excreted into bile by the multidrug resistance-associated protein 2 (Mrp2, Abcc2). Although recombinant human breast cancer resistance protein (BCRP, ABCG2) has affinity for sulfated