Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lindsey M. Orchard"'
Autor:
Jessica Connacher, Gabrielle A. Josling, Lindsey M. Orchard, Janette Reader, Manuel Llinás, Lyn-Marié Birkholtz
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional and morphological cha
Externí odkaz:
https://doaj.org/article/553d408fb73241498f3bbf3cac847379
Autor:
Janette Reader, Mariëtte E. van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja Lauterbach, Belinda Bezuidenhout, Andre Horatscheck, Ashleigh van Heerden, Natalie J. Spillman, Anne N. Cowell, Jessica Connacher, Daniel Opperman, Lindsey M. Orchard, Manuel Llinás, Eva S. Istvan, Daniel E. Goldberg, Grant A. Boyle, David Calvo, Dalu Mancama, Theresa L. Coetzer, Elizabeth A. Winzeler, James Duffy, Lizette L. Koekemoer, Gregory Basarab, Kelly Chibale, Lyn-Marié Birkholtz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-bl
Externí odkaz:
https://doaj.org/article/469ad5b32c23403795a07ad1d5fdbabe
Autor:
Che J. Ngwa, Meike J. Kiesow, Olga Papst, Lindsey M. Orchard, Michael Filarsky, Alina N. Rosinski, Till S. Voss, Manuel Llinás, Gabriele Pradel
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Transmission of the malaria parasite Plasmodium falciparum from the human to the mosquito is mediated by the intraerythrocytic gametocytes, which, once taken up during a blood meal, become activated to initiate sexual reproduction. Because gametocyte
Externí odkaz:
https://doaj.org/article/7b9529ec46544f6d8a5e486ad64448bb
Autor:
John Okombo, Sachel Mok, Tarrick Qahash, Tomas Yeo, Jade Bath, Lindsey M Orchard, Edward Owens, Imhoi Koo, Istvan Albert, Manuel Llinás, David A Fidock
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010926 (2022)
The emergence of Plasmodium falciparum parasite resistance to dihydroartemisinin + piperaquine (PPQ) in Southeast Asia threatens plans to increase the global use of this first-line antimalarial combination. High-level PPQ resistance appears to be med
Externí odkaz:
https://doaj.org/article/5c25b32a34e4401c9b86a31cea46de14
Autor:
Sandra Bennink, Andreas von Bohl, Che J Ngwa, Leonie Henschel, Andrea Kuehn, Nicole Pilch, Tim Weißbach, Alina N Rosinski, Matthias Scheuermayer, Urska Repnik, Jude M Przyborski, Allen M Minns, Lindsey M Orchard, Gareth Griffiths, Scott E Lindner, Manuel Llinás, Gabriele Pradel
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007249 (2018)
The complex life-cycle of the human malaria parasite Plasmodium falciparum requires a high degree of tight coordination allowing the parasite to adapt to changing environments. One of the major challenges for the parasite is the human-to-mosquito tra
Externí odkaz:
https://doaj.org/article/524c2973888440ce8e6bba3516359498
Autor:
Riward A. Campelo Morillo, Xinran Tong, Wei Xie, Steven Abel, Lindsey M. Orchard, Wassim Daher, Dinshaw J. Patel, Manuel Llinás, Karine G. Le Roch, Björn F. C. Kafsack
Publikováno v:
Nature microbiology, vol 7, iss 2
Transmission of Plasmodium falciparum and other malaria parasites requires their differentiation from asexual blood stages into gametocytes, the non-replicative sexual stage necessary to infect the mosquito vector. This transition involves changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcbea72e8c64cea5481383c49db4fd5
https://escholarship.org/uc/item/6fg9w3jj
https://escholarship.org/uc/item/6fg9w3jj
Autor:
Timothy J. Russell, Lia Chappell, Lindsey M. Orchard, Julian C. Rayner, Philipp Ross, Thomas D. Otto, Manuel Llinás, Matthew Berriman
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-19 (2020)
BMC Genomics
BMC Genomics
Background Plasmodium parasites undergo several major developmental transitions during their complex lifecycle, which are enabled by precisely ordered gene expression programs. Transcriptomes from the 48-h blood stages of the major human malaria para
Autor:
Kelly Chibale, Janette Reader, Jandeli Niemand, Roelof Daniel Jacobus Van Wyk, Lyn-Marie Birkholtz, Ashleigh van Heerden, Manuel Llinás, Lindsey M. Orchard, Riëtte van Biljon, Mariëtte van der Watt
Publikováno v:
ACS infectious diseases. 7(10)
Kinase-focused inhibitors previously revealed compounds with differential activity against different stages of Plasmodium falciparum gametocytes. MMV666810, a 2-aminopyrazine, is more active on late-stage gametocytes, while a pyrazolopyridine, MMV674
Autor:
Joanne M. Morrisey, Heather J. Painter, Michael K. Riscoe, Akhil B. Vaidya, Lindsey M. Orchard, Martin J. Smilkstein, Cuyler Luck, Manuel Llinás, Michael W. Mather
Publikováno v:
Antimicrob Agents Chemother
The continued emergence of drug-resistant Plasmodium falciparum parasites hinders global attempts to eradicate malaria, emphasizing the need to identify new antimalarial drugs. Attractive targets for chemotherapeutic intervention are the cytochrome (
Autor:
Riëtte van Biljon, Lindsey M. Orchard, Suprita Singh, Manuel Llinás, Heather J. Painter, Shaun Mahony, Naomi Yamada, Joana M. Santos
Publikováno v:
Mol Microbiol
Differentiation from asexual blood stages to sexual gametocytes is required for transmission of malaria parasites from the human to the mosquito host. Preventing gametocyte commitment and development would block parasite transmission, but the underly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db8be7f2cbba4ec4d45af0108dc484d
https://europepmc.org/articles/PMC8330521/
https://europepmc.org/articles/PMC8330521/