Výsledky vyhledávání - "Lindsey K, Sachs"

Akademický článek

Human CD4+CD25+CD226- Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4+CD25+CD127lo/- Tregs for Adoptive Cell Therapy

Autor: Matthew E. Brown, Leeana D. Peters, Seif R. Hanbali, Juan M. Arnoletti, Lindsey K. Sachs, Kayla Q. Nguyen, Emma B. Carpenter, Howard R. Seay, Christopher A. Fuhrman, Amanda L. Posgai, Melanie R. Shapiro, Todd M. Brusko

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Regulatory T cell (Treg) adoptive cell therapy (ACT) represents an emerging strategy for restoring immune tolerance in autoimmune diseases. Tregs are commonly purified using a CD4+CD25+CD127lo/- gating strategy, which yields a mixed population: 1) ce

Externí odkaz: https://doaj.org/article/ee8774329b694e21a6e707bc96062b84

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Deletion of CD226 in Foxp3+ T cells Reduces Diabetes Incidence in Non-Obese Diabetic Mice by Improving Regulatory T Cell Stability and Function

Autor: Puchong Thirawatananond, Matthew E. Brown, Lindsey K. Sachs, Juan M. Arnoletti, Wen-I Yeh, Amanda L. Posgai, Melanie R. Shapiro, Yi-Guang Chen, Todd M. Brusko

Co-stimulation serves as a critical checkpoint for T cell development and activation, and several genetic variants affecting co-stimulatory pathways confer risk for autoimmune diseases. A single nucleotide polymorphism in CD226 (rs763361; G307S) has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b0299f82ef86cd7055a30369fba428f
https://doi.org/10.1101/2022.06.02.494443

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Human CD4

Autor: Matthew E, Brown, Leeana D, Peters, Seif R, Hanbali, Juan M, Arnoletti, Lindsey K, Sachs, Kayla Q, Nguyen, Emma B, Carpenter, Howard R, Seay, Christopher A, Fuhrman, Amanda L, Posgai, Melanie R, Shapiro, Todd M, Brusko

Publikováno v: Frontiers in immunology. 13

Regulatory T cell (Treg) adoptive cell therapy (ACT) represents an emerging strategy for restoring immune tolerance in autoimmune diseases. Tregs are commonly purified using a CD4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc48a41169ccd1c2f7242ac63979071a
https://pubmed.ncbi.nlm.nih.gov/35693814

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