Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lindsey K, Boroughs"'
Autor:
John V. Heymach, John D. Minna, Ralph J. DeBerardinis, Ferdinandos Skoulidis, Varsha Gandhi, Jing Wang, Francesco Parlati, Winter Zhang, Mirna L.M. Rodriguez, Lindsey K. Boroughs, Pei-Hsuan Chen, Pan Tong, Marlese A. Pisegna, Alissa Poteete, Xiao Qu, Piyada Sitthideatphaiboon, Ana Galan-Cobo
In KRAS-mutant lung adenocarcinoma, tumors with LKB1 loss (KL) are highly enriched for concurrent KEAP1 mutations, which activate the KEAP1/NRF2 pathway (KLK). Here, we investigated the biological consequences of these cooccurring alterations and exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2efb6bf974b8a43395329e688bf871
https://doi.org/10.1158/0008-5472.c.6510938.v1
https://doi.org/10.1158/0008-5472.c.6510938.v1
Autor:
John V. Heymach, John D. Minna, Ralph J. DeBerardinis, Ferdinandos Skoulidis, Varsha Gandhi, Jing Wang, Francesco Parlati, Winter Zhang, Mirna L.M. Rodriguez, Lindsey K. Boroughs, Pei-Hsuan Chen, Pan Tong, Marlese A. Pisegna, Alissa Poteete, Xiao Qu, Piyada Sitthideatphaiboon, Ana Galan-Cobo
Abbreviations used in the manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a01bdfa5c985b6326918ded87ce86d
https://doi.org/10.1158/0008-5472.22421474.v1
https://doi.org/10.1158/0008-5472.22421474.v1
Autor:
John V. Heymach, John D. Minna, Ralph J. DeBerardinis, Ferdinandos Skoulidis, Varsha Gandhi, Jing Wang, Francesco Parlati, Winter Zhang, Mirna L.M. Rodriguez, Lindsey K. Boroughs, Pei-Hsuan Chen, Pan Tong, Marlese A. Pisegna, Alissa Poteete, Xiao Qu, Piyada Sitthideatphaiboon, Ana Galan-Cobo
Supplementary bioinformatic analysis and CB-839 effects on in vitro cell proliferation, ROS stress and metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13da4f81e5c7de81e10d6cf4c6c96569
https://doi.org/10.1158/0008-5472.22421477
https://doi.org/10.1158/0008-5472.22421477
Autor:
Akash K. Kaushik, Amy Tarangelo, Lindsey K. Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina T. Tcheuyap, Faeze Saatchi, Quyen N. Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D. Rao, Brandon Faubert, Panayotis Pachnis, Lauren G. Zacharias, Hieu Vu, Feng Cai, Thomas P. Mathews, Giannicola Genovese, Barbara S. Slusher, Payal Kapur, Xiankai Sun, Matthew Merritt, James Brugarolas, Ralph J. DeBerardinis
Publikováno v:
Science advances. 8(50)
Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts from VHL -mutant cle
Autor:
Andrew R. Mullen, Zeping Hu, Xiaolei Shi, Lei Jiang, Lindsey K. Boroughs, Zoltan Kovacs, Richard Boriack, Dinesh Rakheja, Lucas B. Sullivan, W. Marston Linehan, Navdeep S. Chandel, Ralph J. DeBerardinis
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1679-1690 (2014)
Mammalian cells generate citrate by decarboxylating pyruvate in the mitochondria to supply the tricarboxylic acid (TCA) cycle. In contrast, hypoxia and other impairments of mitochondrial function induce an alternative pathway that produces citrate by
Externí odkaz:
https://doaj.org/article/672968f1722f4fe88dc7b10759c626f1
Autor:
John V. Heymach, Varsha Gandhi, Francesco Parlati, Lindsey K. Boroughs, Ralph J. DeBerardinis, Jing Wang, Piyada Sitthideatphaiboon, Ferdinandos Skoulidis, Ana Galan-Cobo, John D. Minna, Mirna Rodriguez, Winter Zhang, Alissa Poteete, Xiao Qu, Pan Tong, Pei Hsuan Chen, Marlese Pisegna
Publikováno v:
Cancer Research. 79:3251-3267
In KRAS-mutant lung adenocarcinoma, tumors with LKB1 loss (KL) are highly enriched for concurrent KEAP1 mutations, which activate the KEAP1/NRF2 pathway (KLK). Here, we investigated the biological consequences of these cooccurring alterations and exp
Autor:
Hollis Notgrass, Hua Zhong, Andrea Pavia-Jimenez, Vanina Tcheuyap, Ming Gao, Vitaly Margulis, Roy Elias, Ivan Pedrosa, Aditi Mulgaonkar, Oscar Reig Torras, Nirmish Singla, Christina Stevens, Zora Modrusan, Layton Woolford, Brandi L. Cantarel, Xiankai Sun, Marianna Dakanali, Ralph J. DeBerardinis, Somasekar Seshagiri, Kavitha Priya Kettimuthu, Allison Joyce, Jeffrey A. Cadeddu, Noelle S. Williams, Akash K. Kaushik, Orhan K. Öz, Payal Kapur, Alana Christie, Lindsey K. Boroughs, James Brugarolas
Publikováno v:
Cell reports
SUMMARY Renal cell carcinoma (RCC) encompasses a heterogenous group of tumors, but representative preclinical models are lacking. We previously showed that patient-derived tumorgraft (TG) models recapitulate the biology and treatment responsiveness.
Autor:
Jessica Sudderth, Lindsey K. Boroughs, Michael A. White, Rebecca Britt, Hyun Seok Kim, Bo Yao, Guanghua Xiao, Misty D. Shields, Jiyeon Kim, Ling Cai, John V. Heymach, Dong Chen, David S. Shames, Michael Peyton, Elizabeth A. McMillan, Luc Girard, Lauren Averett Byers, Brenda C. Timmons, Ralph J. DeBerardinis, Kenneth E. Huffman, Stephanie Weber, Brandon Faubert, Bookyung Ko, John D. Minna, Jing Chen, Pei Hsuan Chen, Ikuo Sekine, Chendong Yang
Publikováno v:
Mol Cell
Intermediary metabolism in cancer cells is regulated by diverse cell-autonomous processes, including signal transduction and gene expression patterns, arising from specific oncogenotypes and cell lineages. Although it is well established that metabol
Autor:
Luc Girard, Misty D. Shields, Bookyung Ko, John V. Heymach, Brandon Faubert, John D. Minna, Ralph J. DeBerardinis, Hyun Seok Kim, Lauren Averett Byers, David S. Shames, Elizabeth A. McMillan, Chendong Yang, Michael Peyton, Lindsey K. Boroughs, Michael A. White, Jiyeon Kim, Kenneth E. Huffman, Ikuo Sekine, Rebecca Britt, Guanghua Xiao, Ling Cai, Jessica Sudderth, Brenda C. Timmons, Stephanie Weber, Pei Hsuan Chen
SummaryIntermediary metabolism in cancer cells is regulated by diverse cell-autonomous processes including signal transduction and gene expression patterns arising from specific oncogenotypes and cell lineages. Although it is well established that me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511e6390dededdd8f74086bc929d2d99
Autor:
Ana, Galan-Cobo, Piyada, Sitthideatphaiboon, Xiao, Qu, Alissa, Poteete, Marlese A, Pisegna, Pan, Tong, Pei-Hsuan, Chen, Lindsey K, Boroughs, Mirna L M, Rodriguez, Winter, Zhang, Francesco, Parlati, Jing, Wang, Varsha, Gandhi, Ferdinandos, Skoulidis, Ralph J, DeBerardinis, John D, Minna, John V, Heymach
Publikováno v:
Cancer Res
In KRAS-mutant lung adenocarcinoma, tumors with LKB1 loss (KL) are highly enriched for concurrent KEAP1 mutations, which activate the KEAP1/NRF2 pathway (KLK). Here we investigated the biological consequences of these co-occurring alterations and exp