CB1R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome

Autor: Resat Cinar, Joshua K. Park, Charles N. Zawatsky, Nathan J. Coffey, Steven P. Bodine, Jasmina Abdalla, Tadafumi Yokoyama, Tony Jourdan, Lindsey Jay, Mei Xing G. Zuo, Kevin J. O'Brien, Junfeng Huang, Ken Mackie, Asaf Alimardanov, Malliga R. Iyer, William A. Gahl, George Kunos, Bernadette R. Gochuico, May Christine V. Malicdan

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 7, Pp n/a-n/a (2021)

Abstract Hermansky–Pudlak syndrome (HPS) is a rare genetic disorder which, in its most common and severe form, HPS‐1, leads to fatal adult‐onset pulmonary fibrosis (PF) with no effective treatment. We evaluated the role of the endocannabinoid/C

Externí odkaz: https://doaj.org/article/6b58354bc8cd41de976ad8a5c91da796

Bleomycin Induces Drug Efflux in Lungs. A Pitfall for Pharmacological Studies of Pulmonary Fibrosis

Autor: Nathan J. Coffey, Lindsey Jay, Joshua K. Park, Resat Cinar, Steven P. Bodine, Charles N. Zawatsky, William A. Gahl, May Christine V. Malicdan, George Kunos, Bernadette R. Gochuico

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 62:178-190

ATP-binding cassette (ABC) transporters are evolutionarily conserved membrane proteins that pump a variety of endogenous substrates across cell membranes. Certain subfamilies are known to interact with pharmaceutical compounds, potentially influencin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33b70e47d7fd66ba3903ad487b3a7e7b
https://doi.org/10.1165/rcmb.2018-0147oc

SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces

Autor: Chris I. De Zeeuw, Martijn Schonewille, Lisa van Beers, Silas E. Busch, Lindsey Jay, Gerco C. Beekhof, Giorgio Grasselli, Heather K. Titley, Christian Hansel, Nora Bradford, Henk-Jan Boele

Publikováno v: PLoS Biology (print), 18(1):e3000596. Public Library of Science
PLoS Biology, 18(1). Public Library of Science
PLoS Biology
PLoS Biology, Vol 18, Iss 1, p e3000596 (2020)

Neurons store information by changing synaptic input weights. In addition, they can adjust their membrane excitability to alter spike output. Here, we demonstrate a role of such “intrinsic plasticity” in behavioral learning in a mouse model that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c76bdd6eec8fc2cee9cd7a9d48d8ef
https://doi.org/10.1371/journal.pbio.3000596

The DGCR5 long noncoding RNA may regulate expression of several schizophrenia-related genes

Autor: Tonya M. Brunetti, Kevin P. White, Heather Eckart, Amber Thomas, Kangli Wang, Dominic Fitzgerald, Yan Xia, Rujia Dai, Mingfeng Li, Kay Grennan, Chunyu Liu, Lindsey Jay, Nenad Sestan, Yuka Imamura-Kawasawa, Chao Chen, Chuan Jiao, Qingtuan Meng

Publikováno v: Science Translational Medicine. 10

A number of studies indicate that rare copy number variations (CNVs) contribute to the risk of schizophrenia (SCZ). Most of these studies have focused on protein-coding genes residing in the CNVs. Here, we investigated long noncoding RNAs (lncRNAs) w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7744b2b6d09bee28b6425839799b8c4a
https://doi.org/10.1126/scitranslmed.aat6912

DNA polymerase iota promotes G2/M checkpoint activation and genetic stability after UV-induced DNA damage

Autor: Lindsey Jay Stallons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::348e0294de07d4e877da9ff107b78e55
https://doi.org/10.18297/etd/1369