Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Lindsey I James"'
Autor:
Stuart R Jefferys, Samuel D Burgos, Jackson J Peterson, Sara R Selitsky, Anne-Marie W Turner, Lindsey I James, Yi-Hsuan Tsai, Alisha R Coffey, David M Margolis, Joel Parker, Edward P Browne
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009346 (2021)
Transcriptional silencing of HIV in CD4 T cells generates a reservoir of latently infected cells that can reseed infection after interruption of therapy. As such, these cells represent the principal barrier to curing HIV infection, but little is know
Externí odkaz:
https://doaj.org/article/685a177c1c5c40da8c212b641f7fd494
Autor:
Sharon E Hopcraft, Samantha G Pattenden, Lindsey I James, Stephen Frye, Dirk P Dittmer, Blossom Damania
Publikováno v:
PLoS Pathogens, Vol 14, Iss 9, p e1007267 (2018)
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of three human malignancies, the endothelial cell cancer Kaposi's sarcoma, and two B cell cancers, Primary Effusion Lymphoma and multicentric Castleman's disease. KSHV has latent a
Externí odkaz:
https://doaj.org/article/6266cec14ee44700bf29a25343f0927f
Autor:
Gaofeng Cui, Maria Victoria Botuyan, Pascal Drané, Qi Hu, Benoît Bragantini, James R. Thompson, David J. Schuller, Alexandre Detappe, Michael T. Perfetti, Lindsey I. James, Stephen V. Frye, Dipanjan Chowdhury, Georges Mer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The recruitment of 53BP1 to chromatin, mediated by its recognition of histone H4 dimethylated at lysine 20 (H4K20me2), is important for DNA double-strand break repair. Using a series of small molecule antagonists, we demonstrate a conformati
Externí odkaz:
https://doaj.org/article/0f5b7e97b6324cda80e7ab7f47fa3f98
Autor:
Zhao‐Wei Sun, Jarod M. Waybright, Serap Beldar, Lu Chen, Caroline A. Foley, Jacqueline L. Norris‐Drouin, Tian‐Jie Lyu, Aiping Dong, Jinrong Min, Yu‐Pu Wang, Lindsey I. James, Yun Wang
Publikováno v:
Advanced Science, Vol 10, Iss 25, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/d70ec315f7cd45e58fcaefeae7f5874e
Autor:
Tamara Vital, Aminah Wali, Kyle V. Butler, Yan Xiong, Joseph P. Foster, Shelsa S. Marcel, Andrew W. McFadden, Valerie U. Nguyen, Benton M. Bailey, Kelsey N. Lamb, Lindsey I. James, Stephen V. Frye, Amber L. Mosely, Jian Jin, Samantha G. Pattenden, Ian J. Davis
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment o
Externí odkaz:
https://doaj.org/article/7ebda3c984ec4911991fbe839ad7aab9
Autor:
Ronan P. Hanley, David Y. Nie, John R. Tabor, Fengling Li, Amin Sobh, Chenxi Xu, Natalie K. Barker, David Dilworth, Taraneh Hajian, Elisa Gibson, Magdalena M. Szewczyk, Peter J. Brown, Dalia Barsyte-Lovejoy, Laura E. Herring, Gang Greg Wang, Jonathan D. Licht, Masoud Vedadi, Cheryl H. Arrowsmith, Lindsey I. James
Publikováno v:
Journal of the American Chemical Society. 145:8176-8188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95bc98e1fc4dc9f993866f26284bf64e
https://doi.org/10.1021/jacs.3c01421
https://doi.org/10.1021/jacs.3c01421
Autor:
Frances M. Bashore, Caroline A. Foley, Han Wee Ong, Justin M. Rectenwald, Ronan P. Hanley, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Christine A. Mills, Kenneth H. Pearce, Laura E. Herring, Dmitri Kireev, Stephen V. Frye, Lindsey I. James
Publikováno v:
ACS Chemical Biology. 18:494-507
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f07a145587e308b683ae0e8ff599158
https://doi.org/10.1021/acschembio.2c00804
https://doi.org/10.1021/acschembio.2c00804
Autor:
Cathy J. Spangler, Aleksandra Skrajna, Caroline A. Foley, Anh Nguyen, Gabrielle R. Budziszewski, Dalal N. Azzam, Eyla C. Arteaga, Holly C. Simmons, Charlotte B. Smith, Nathaniel A. Wesley, Emily M. Wilkerson, Jeanne-Marie E. McPherson, Dmitri Kireev, Lindsey I. James, Stephen V. Frye, Dennis Goldfarb, Robert K. McGinty
Publikováno v:
Nature Chemical Biology. 19:624-632
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e92720ce51947090d9ebe2b31e532414
https://doi.org/10.1038/s41589-023-01256-y
https://doi.org/10.1038/s41589-023-01256-y
Autor:
Mélanie Uguen, Yu Deng, Fengling Li, Devan J. Shell, Jacqueline L. Norris-Drouin, Michael A. Stashko, Suzanne Ackloo, Cheryl H. Arrowsmith, Lindsey I. James, Pengda Liu, Kenneth H. Pearce, Stephen V. Frye
Publikováno v:
bioRxiv
Increased expression and hyperactivation of the methyltransferase SETDB1 are commonly observed in cancer and central nervous system disorders. However, there are currently no reported SETDB1-specific methyltransferase inhibitors in the literature, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6935d47261a73543a1a18915cbf62a28
https://doi.org/10.1101/2023.05.10.539986
https://doi.org/10.1101/2023.05.10.539986
Autor:
Qing Zhang, Kan Gong, Albert S. Baldwin, Xianming Tan, Chengheng Liao, Kai Hong, Johnny Castillo Cabrera, Xian Chen, Ling Xie, Laura E. Herring, Emily M. Wilkerson, Lindsey I. James, Frances Potjewyd, Xijuan Liu, Haibiao Xie, Lianxin Hu
TANK binding kinase 1 (TBK1) is an important kinase involved in the innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from patients with kidney cancer with VHL loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c9a565c848d2100f8b2b6302d6c942
https://doi.org/10.1158/2159-8290.c.6547922.v1
https://doi.org/10.1158/2159-8290.c.6547922.v1