Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lindsey Gumbrell"'
Autor:
Lisa K. Folkes, Luiza Sena, Helen Anderson, Gordon J. S. Rustin, Susan M. Galbraith, Michael R.L. Stratford, Lindsey Gumbrell, Patricia M Price
Publikováno v:
Journal of Clinical Oncology. 21:2815-2822
Purpose: A phase I trial was performed with combretastatin A4 phosphate (CA4P), a novel tubulin-binding agent that has been shown to rapidly reduce blood flow in animal tumors. Patients and Methods: The drug was delivered by a 10-minute weekly infusi
Autor:
Michael B. Jameson, Susan M. Galbraith, Paul Thompson, Martin A. Lodge, Anwar R. Padhani, David Hough, J. James Stirling, Lindsey Gumbrell, Gordon J. S. Rustin, N. Jane Taylor
Publikováno v:
Journal of Clinical Oncology. 20:3826-3840
PURPOSE: 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) causes vascular shutdown in preclinical models. Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) studies were performed in the phase I trials to examine changes related to blood fl
Autor:
Thomas W. J. Lennard, Lindsey Gumbrell, Michael Millward, Michael J. Lind, Angela Robinson, Brian M. J. Cantwell
Publikováno v:
Breast Cancer Research and Treatment. 29:271-277
Ifosfamide has single agent activity in advanced breast cancer and may potentiate the activity of doxorubicin. The combination of ifosfamide 5 g/m2 and doxorubicin 40 mg/m2 every 3 weeks for 4 cycles was used to treat 77 patients with advanced breast
Autor:
Massimo Zucchetti, Benjamin Winograd, Sergio Frustaci, Enrico Davoli, Lindsey Gumbrell, Cavalli Franco, Raffaele Califano, Maurizio D'Incalci, Aaron Sulkes, Cristiana Sessa
Publikováno v:
Journal of the National Cancer Institute. 83(16)
The toxicity profile and the pharmacokinetics of aphidicolin glycinate, a water-soluble analogue of aphidicolin, have been evaluated in two consecutive phase I clinical studies. In the first study, aphidicolin glycinate was given by 1-hour infusion f