Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lindsey Glenn"'
12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes
Autor:
Abhishek Kulkarni, Annie R. Pineros, Melissa A. Walsh, Isabel Casimiro, Sara Ibrahim, Marimar Hernandez-Perez, Kara S. Orr, Lindsey Glenn, Jerry L. Nadler, Margaret A. Morris, Sarah A. Tersey, Raghavendra G. Mirmira, Ryan M. Anderson
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
Macrophages and related myeloid cells are innate immune cells that participate in the early islet inflammation of type 1 diabetes (T1D). The enzyme 12-lipoxygenase (12-LOX) catalyzes the formation of proinflammatory eicosanoids, but its role and mech
Externí odkaz:
https://doaj.org/article/34a90733e3ad4b8893ca68306c5ee215
12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes
Autor:
Melissa A Walsh, Lindsey Glenn, Sarah A. Tersey, Raghavendra G. Mirmira, Sara Ibrahim, Ryan M. Anderson, Margaret A. Morris, Isabel Casimiro, Abhishek Kulkarni, Kara S. Orr, Annie R. Piñeros, Marimar Hernandez-Perez, Jerry L. Nadler
Publikováno v:
JCI Insight
Macrophages and related myeloid cells are innate immune cells that participate in the early islet inflammation of type 1 diabetes (T1D). The enzyme 12-lipoxygenase (12-LOX) catalyzes the formation of proinflammatory eicosanoids, but its role and mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d37152cfd9e8102eca1206581176ec4
https://pubmed.ncbi.nlm.nih.gov/34128835
https://pubmed.ncbi.nlm.nih.gov/34128835
Autor:
Annie Piñeros, Abhishek Kulkarni, Hongyu Gao, Kara Orr, Lindsey Glenn, Fei Huang, Yunlong Liu, Maureen Gannon, Farooq Syed, Wenting Wu, Carmella Evans-Molina, Marcia McDuffie, Jerry Nadler, Margaret Morris, Raghu Mirmira, Sarah Tersey
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfee94af960565219b45c48da8482952
https://doi.org/10.2139/ssrn.3976480
https://doi.org/10.2139/ssrn.3976480
Autor:
Annie R. Piñeros, Abhishek Kulkarni, Hongyu Gao, Kara S. Orr, Lindsey Glenn, Fei Huang, Yunlong Liu, Maureen Gannon, Farooq Syed, Wenting Wu, Cara M. Anderson, Carmella Evans-Molina, Marcia McDuffie, Jerry L. Nadler, Margaret A. Morris, Raghavendra G. Mirmira, Sarah A. Tersey
Publikováno v:
Cell Reports. 39:111011
Type 1 diabetes is a disorder of immune tolerance that leads to death of insulin-producing islet β cells. We hypothesize that inflammatory signaling within β cells promotes progression of autoimmunity within the islet microenvironment. To test this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5efae739406cad16eb4eff15d0a19e6
https://doi.org/10.1016/j.celrep.2022.111011
https://doi.org/10.1016/j.celrep.2022.111011
Autor:
Kara S. Orr, Abhishek Kulkarni, Margaret A. Morris, Jerry L. Nadler, Raghavendra G. Mirmira, Christopher A. Reissaus, Marcia McDuffie, Sarah A. Tersey, Lindsey Glenn, Marimar Hernandez-Perez, Annie R. Piñeros
Publikováno v:
Diabetes. 69
The pathogenesis of type 1 diabetes (T1D) involves the interaction of the immune system with β cells. 12/15-lipoxygenase (12/15-LOX), an enzyme involved in arachidonic acid metabolism, is highly expressed in both β cells and macrophages. Global del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7772142c2a62ef2222b83b75a469f37d
https://doi.org/10.2337/db20-288-or
https://doi.org/10.2337/db20-288-or
Autor:
Abhishek Kulkarni, Margaret A. Morris, Marcia McDuffie, Lindsey Glenn, Maureen Gannon, Christopher A. Reissaus, Kara S. Orr, Sarah A. Tersey, Marimar Hernandez-Perez, Jerry L. Nadler, Annie R. Piñeros, Raghavendra G. Mirmira
Publikováno v:
Diabetes. 69
The type 1 diabetes (T1D) pathogenesis has been viewed as being initiated and propagated by directed autoimmunity against islet β cells. In recent years, we and others have taken a new perspective placing the β cell itself as the initiating cell. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0484c6e73f9740d698b44bdfe1f71dc
https://doi.org/10.2337/db20-85-or
https://doi.org/10.2337/db20-85-or
Autor:
Vijay Gottipati, Anna Marley, William L. McPheat, Bronson A. Haynes, Lindsey Glenn, Jerry L. Nadler, Göran I. Hansson, Ryan W. Huyck, Anca D. Dobrian
Publikováno v:
Prostaglandins & Other Lipid Mediators. 136:23-32
The 12-lipoxygenase (12LO) pathway is a promising target to reduce islet dysfunction, adipose tissue (AT) inflammation and insulin resistance. Optimal pre-clinical models for the investigation of selective12LO inhibitors in this context have not yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05af72e2348b83fa97647030e0991ac3
https://doi.org/10.1016/j.prostaglandins.2018.03.003
https://doi.org/10.1016/j.prostaglandins.2018.03.003
Autor:
Raghavendra G. Mirmira, Kaiwen Ma, So Hyun Park, Jessica R. Weaver, Tatvam Barot, Diane K. Luci, David A. Taylor-Fishwick, Yumi Imai, David J. Maloney, Jerry L. Nadler, Laura Jackson, An Xiao, Lindsey Glenn
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 102:2789-2797
Context The 12-lipoxygenase (12-LO) pathway produces proinflammatory metabolites, and its activation is implicated in islet inflammation associated with type 1 and type 2 diabetes (T2D). Objectives We aimed to test the efficacy of ML355, a highly sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4cdda3d4ebc0ea88124b7784305d4e
https://doi.org/10.1210/jc.2017-00267
https://doi.org/10.1210/jc.2017-00267
Autor:
Kara S. Orr, Maureen Gannon, Sarah A. Tersey, Jerry L. Nadler, Raghavendra G. Mirmira, Christopher A. Reissaus, Abhishek Kulkarni, Margaret A. Morris, Marcia McDuffie, Marimar Hernandez-Perez, Annie Rocio Pineros Alvarez, Lindsey Glenn
Publikováno v:
Diabetes. 68
The pathogenesis of type 1 diabetes (T1D) involves the interaction of the immune system with β cells. 12/15-lipoxygenase (12/15-LOX), an enzyme involved in arachidonic acid metabolism, is expressed in both β cells and macrophages. Global deletion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fa314697ac6eaac16c6fd2c824392a8
https://doi.org/10.2337/db19-359-or
https://doi.org/10.2337/db19-359-or
Autor:
Kara S. Orr, Andrew Pearson, Lindsey Glenn, David Taylor, Sarah A. Tersey, David A. Taylor-Fishwick
Publikováno v:
Integrative Molecular Medicine. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d712f2ad13bf0c59521f5d062dfb3386
https://doi.org/10.15761/imm.1000367
https://doi.org/10.15761/imm.1000367