Výsledky vyhledávání - "Lindsey E. Bazzone"

Akademický článek

ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection

Autor: Lindsey E. Bazzone, Junji Zhu, Michael King, GuanQun Liu, Zhiru Guo, Christopher R. MacKay, Pyae P. Kyawe, Natasha Qaisar, Joselyn Rojas-Quintero, Caroline A. Owen, Abraham L. Brass, William McDougall, Christina E. Baer, Timothy Cashman, Chinmay M. Trivedi, Michaela U. Gack, Robert W. Finberg, Evelyn A. Kurt-Jones

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Viral myocarditis, an inflammatory disease of the heart, causes significant morbidity and mortality. Type I interferon (IFN)-mediated antiviral responses protect against myocarditis, but the mechanisms are poorly understood. We previously id

Externí odkaz: https://doaj.org/article/3a421e72f14049aabaa33306c2d34a1f

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Akademický článek

A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection

Autor: Lindsey E. Bazzone, Michael King, Christopher R. MacKay, Pyae P. Kyawe, Paul Meraner, Daniel Lindstrom, Joselyn Rojas-Quintero, Caroline A. Owen, Jennifer P. Wang, Abraham L. Brass, Evelyn A. Kurt-Jones, Robert W. Finberg

Publikováno v: mBio, Vol 10, Iss 1 (2019)

ABSTRACT Encephalomyocarditis virus (EMCV) is a picornavirus that produces lytic infections in murine and human cells. Employing a genome-wide CRISPR-Cas9 knockout screen to find host factors required for EMCV infection, we identified a role for ADAM

Externí odkaz: https://doaj.org/article/0718071866f9446d8c16a518b045e864

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A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection

Autor: Jennifer P. Wang, Lindsey E. Bazzone, Christopher R. MacKay, Daniel Lindstrom, Paul Meraner, Abraham L. Brass, Pyae Phyo Kyawe, Robert W. Finberg, Michael King, Joselyn Rojas-Quintero, Evelyn A. Kurt-Jones, Caroline A. Owen

Publikováno v: mBio
mBio, Vol 10, Iss 1, p e02734-18 (2019)
mBio, Vol 10, Iss 1 (2019)

Viral myocarditis is a leading cause of death in the United States, contributing to numerous unexplained deaths in people ≤35 years old. Enteroviruses contribute to many cases of human myocarditis. Encephalomyocarditis virus (EMCV) infection causes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f62185745d1ae45a60c4fd9a2817b88
http://europepmc.org/articles/PMC6428755

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Mechanistic Study of Broadly Neutralizing Human Monoclonal Antibodies against Dengue Virus That Target the Fusion Loop

Autor: James E. Robinson, John S. Schieffelin, Sharon Isern, Li Lin, Benjamin J. Doranz, Amanda S. Graham, Kristen M. Kahle, Cindo O. Nicholson, Leonid V. Chernomordik, Scott F. Michael, Marielys Figueroa Sierra, Sung-Tae Yang, Rachel H. Fong, Joshua M. Costin, Dawne K. Rowe, Elena Zaitseva, Lindsey E. Bazzone, Greg Hogancamp

Publikováno v: Journal of Virology. 87:52-66

There are no available vaccines for dengue, the most important mosquito-transmitted viral disease. Mechanistic studies with anti-dengue virus (DENV) human monoclonal antibodies (hMAbs) provide a rational approach to identify and characterize neutrali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef2c9b5971bc80e6899176134a678a5
https://doi.org/10.1128/jvi.02273-12

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Genetic Control of Severe Egg-Induced Immunopathology and IL-17 Production in Murine Schistosomiasis

Autor: Laura I. Rutitzky, Mara G. Shainheit, Alexander Poltorak, Lindsey E. Bazzone, Miguel J. Stadecker, Patrick M. Smith

Publikováno v: The Journal of Immunology. 183:3317-3323

Infection with the trematode parasite Schistosoma mansoni results in a distinct heterogeneity of disease severity, both in humans and in an experimental mouse model. Severe disease is characterized by pronounced hepatic egg-induced granulomatous infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5de95592d823cdd6a4a2405e3dc92d25
https://doi.org/10.4049/jimmunol.0901504

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Dendritic Cell IL-23 and IL-1 Production in Response to Schistosome Eggs Induces Th17 Cells in a Mouse Strain Prone to Severe Immunopathology

Autor: Lindsey E. Bazzone, Patrick M. Smith, Mara G. Shainheit, Andrew C. Wang, Laura I. Rutitzky, Miguel J. Stadecker

Publikováno v: The Journal of Immunology. 181:8559-8567

Infection with schistosomes results in a CD4 T cell-mediated inflammatory reaction against parasite eggs that varies greatly in magnitude both in humans as well as in mice. In the murine disease, the severe form of immunopathology correlates with hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f45ba4e905e3350e2cb081293ac3a9e
https://doi.org/10.4049/jimmunol.181.12.8559

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Coinfection with the Intestinal NematodeHeligmosomoides polygyrusMarkedly Reduces Hepatic Egg-Induced Immunopathology and Proinflammatory Cytokines in Mouse Models of Severe Schistosomiasis

Autor: Joseph F. Urban, Joel V. Weinstock, Mara G. Shainheit, Miguel J. Stadecker, Arthur M. Blum, Laura I. Rutitzky, Lindsey E. Bazzone, Patrick M. Smith, Tommy Setiawan

Publikováno v: Infection and Immunity. 76:5164-5172

Infection with the trematode helminthSchistosoma mansoniresults in a parasite egg-induced, CD4 T-cell-mediated, hepatointestinal granulomatous and fibrosing inflammation that varies greatly in severity, with a higher frequency of milder forms typical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4250823abffe14b09b99c9e159b73df1
https://doi.org/10.1128/iai.00673-08

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Disruption of Interleukin-27 Signaling Results in Impaired Gamma Interferon Production but Does Not Significantly Affect Immunopathology in Murine Schistosome Infection

Autor: Lindsey E. Bazzone, Rosita Saraceno, Laura I. Rutitzky, Mara G. Shainheit, Miguel J. Stadecker

Publikováno v: Infection and Immunity. 75:3169-3177

In schistosomiasis mansoni, parasite eggs cause hepatointestinal granulomatous inflammation and fibrosis mediated by CD4 T cells specific for egg antigens. The severity of disease varies extensively in humans and among mouse strains. Marked disease e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf757c53ef66d1507265600c10bdac1
https://doi.org/10.1128/iai.01053-06

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Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production

Autor: Tommy Setiawan, Arthur M. Blum, David E. Elliott, Joseph F. Urban, John Leung, Joel V. Weinstock, Lindsey E. Bazzone, M. Nedim Ince, Ahmed Metwali, Miguel J. Stadecker

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 181(4)

Helminth exposure appears to protect hosts from inappropriate inflammatory responses, such as those causing inflammatory bowel disease. A recently identified, strongly proinflammatory limb of the immune response is characterized by T cell IL-17 produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e868a2e25848748f0f93b760a29958
https://pubmed.ncbi.nlm.nih.gov/18684931

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IL-23 is required for the development of severe egg-induced immunopathology in schistosomiasis and for lesional expression of IL-17

Autor: Lindsey E. Bazzone, Laura I. Rutitzky, Daniel J. Cua, Mara G. Shainheit, Barbara Joyce-Shaikh, Miguel J. Stadecker

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 180(4)

In infection with the trematode helminth Schistosoma mansoni, the severity of CD4 T cell-mediated hepatic granulomatous and fibrosing inflammation against parasite eggs varies considerably in humans and among mouse strains. In mice, either the natura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cae70ca8d689f8fbcec2a8998b8b10e
https://pubmed.ncbi.nlm.nih.gov/18250458

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