Výsledky vyhledávání - "Lindsey D, Jager"

Human retinal organoids harboring IMPG2 mutations exhibit a photoreceptor outer segment phenotype that models advanced retinitis pigmentosa

Autor: Steven J. Mayerl, Simona Bajgai, Allison L. Ludwig, Lindsey D. Jager, Brittany N. Williams, Cole Bacig, Christopher Stoddard, Divya Sinha, Benjamin D. Philpot, David M. Gamm

Publikováno v: Stem cell reports. 17(11)

Interphotoreceptor matrix proteoglycan 2 (IMPG2) mutations cause a severe form of early-onset retinitis pigmentosa (RP) with macular involvement. IMPG2 is expressed by photoreceptors and incorporated into the matrix that surrounds the inner and outer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce60f6aa073da695a1a563ecb58928c
https://pubmed.ncbi.nlm.nih.gov/36206764

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Imaging Transplanted Photoreceptors in Living Nonhuman Primates with Single-Cell Resolution

Autor: David M. Gamm, Lindsey D. Jager, Kamal Dhakal, Sara Stuedemann, Juliette E. McGregor, David A. DiLoreto, David R. Williams, Brittany Bateman, M. Joseph Phillips, Allison L. Ludwig, William H. Merigan, Ebrahim Aboualizadeh, Jennifer M. Strazzeri, Jennifer J. Hunter, Kelsy L. Nilles

Publikováno v: Stem Cell Reports

Summary Stem cell-based transplantation therapies offer hope for currently untreatable retinal degenerations; however, preclinical progress has been largely confined to rodent models. Here, we describe an experimental platform for accelerating photor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c1db8ef5ce762316be98228de1087b
http://europepmc.org/articles/PMC7419740

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Ultrathin micromolded 3D scaffolds for high-density photoreceptor layer reconstruction

Autor: M. Joseph Phillips, In-Kyu Lee, Allison L. Ludwig, Ruosen Xie, Shaoqin Gong, Benjamin S. Sajdak, David M. Gamm, Juhwan Lee, Lindsey D. Jager, Zhenqiang Ma

Publikováno v: Science Advances

Scaffold microfabrication strategies for high-density, layered, and organized photoreceptor cell replacement are presented.
Polymeric scaffolds are revolutionizing therapeutics for blinding disorders affecting the outer retina, a region anatomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee242d1dc3d27e2e9a1b28f2c6f697f
https://doi.org/10.1126/sciadv.abf0344

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Comparing Staircase and Skilled Forelimb Reaching Tests After Endothelin-1-Induced Stroke

Autor: Susanna S. Kwok, Cassandra L Heilingoetter, Megan L Gilbertson, Jacob R. Richie, Crystal A. Hall, Natanya S. Russek, Joann Huynh, Claire-Marie A. Canda, Matthew B. Jensen, Lindsey D. Jager, Jin H. Kwon

Publikováno v: Journal of Neurology, Neurological Science and Disorders. 3:016-022

Background: Stroke is a leading cause of death and disability worldwide, but there are limited treatment options available despite extensive animal studies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6600fb36e892580a92bbc102965ba6c9
https://doi.org/10.17352/jnnsd.000014

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Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines

Publikováno v: Development (Cambridge, England). 146(1)

Numerous protocols have been described that produce neural retina from human pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids. While nearly all such methods yield at least partial segments of highly mature-appear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac881f901fd1a63ade7a3d910768eb50
https://pubmed.ncbi.nlm.nih.gov/30567931

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Effects of neural differentiation maturity status of human induced pluripotent stem cells prior to grafting in a subcortical ischemic stroke model

Autor: Jin M. Kwon, Cassandra L Heilingoetter, Laura K. Cohen, Matthew B. Jensen, Lindsey D. Jager, Susanna S. Kwok, Crystal A. Hall

Neural cell grafting is a promising therapy for stroke, but the optimal differentiation status of the cells prior to grafting is unclear. We grafted cells at different maturity stages (days 28, 42, or 56 of in vitro neural differentiation) into the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b69f55cce7e3416a52c4c44431391b
https://europepmc.org/articles/PMC5260813/

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Enhancement of Antiviral Immunity by Small Molecule Antagonist of Suppressor of Cytokine Signaling

Autor: Howard M. Johnson, James P. Martin, S. Mohammad Haider, Rea Dabelic, Chulbul M. I. Ahmed, Lindsey D. Jager

Publikováno v: The Journal of Immunology. 185:1103-1113

Suppressors of cytokine signaling (SOCSs) are negative regulators of both innate and adaptive immunity via inhibition of signaling by cytokines such as type I and type II IFNs. We have developed a small peptide antagonist of SOCS-1 that corresponds t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0864c69d5b973cba05a30df96909dd6e
https://doi.org/10.4049/jimmunol.0902895

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Escherichia coli abg Genes Enable Uptake and Cleavage of the Folate Catabolite p -Aminobenzoyl-Glutamate

Autor: Lindsey D. Jager, Lars Gardner, Christel C. Hall, Stacey Willis, Eric L. Carter, Jacalyn M. Green

Publikováno v: Journal of Bacteriology. 189:3329-3334

Escherichia coli AbgT was first identified as a structural protein enabling the growth of p -aminobenzoate auxotrophs on exogenous p -aminobenzoyl-glutamate (M. J. Hussein, J. M. Green, and B. P. Nichols, J. Bacteriol. 180:6260-6268, 1998). The abg r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b047a72b986591d6908d71c306c9eb8
https://doi.org/10.1128/jb.01940-06

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