Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Lindsey Catherine Hess"'
Autor:
Remo Stohler, Reto Brun, Lindsey Catherine Hess, Sandra Sinishtaj, Alvin S. Kalinda, Aimee R. Usera, Kimberly S. Petersen, John G. D'angelo, Gary H. Posner, Theresa A. Shapiro, Andrew S. Rosenthal, Josefina Santo-Tomas, William A. Maio, Christopher Snyder, Sergio Wittlin, Jacques Chollet, Matthias Rottmann, Lauren E. Woodard, Wonsuk Chang
Publikováno v:
Journal of Medicinal Chemistry. 51:1035-1042
In four or five chemical steps from the 1,2,4-trioxane artemisinin, a new series of 23 trioxane dimers has been prepared. Eleven of these new trioxane dimers cure malaria-infected mice via oral dosing at 3 x 30 mg/kg. The clinically used trioxane dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e16abd7fbd9eace1ec0df664837f2f
https://doi.org/10.1021/jm701168h
https://doi.org/10.1021/jm701168h
Autor:
Lindsey Catherine Hess, Gary H. Posner
Publikováno v:
Organic Letters. 12:2120-2122
An efficient and enantiocontrolled three-step synthesis of alpha-hydroxy-(E)-beta,gamma-unsaturated esters is reported. Enantioenriched alpha-selenyl aldehydes, prepared in one step by asymmetric, organocatalytic alpha-selenylation of aldehydes, were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946d2fe9973fa561ee3c67ceea8663cd
https://doi.org/10.1021/ol100615j
https://doi.org/10.1021/ol100615j
Autor:
Lindsey Catherine Hess, Gary H. Posner
Publikováno v:
ChemInform. 41
The method includes preparation of the α-selenyl aldehydes, Wittig reaction, oxidation and the spontaneous [2,3]-sigmatropic rearrangement.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1601514c7a803f8196e95a53c5caafd6
https://doi.org/10.1002/chin.201037063
https://doi.org/10.1002/chin.201037063