Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lindsey Buhring"'
Autor:
David R Powell, Deon D Doree, Christopher M DaCosta, Kenneth A Platt, Robert Brommage, Lindsey Buhring, Jean-Pierre Revelli, Melanie K Shadoan
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.
David R Powell,1 Deon D Doree,1 Christopher M DaCosta,1 Kenneth A Platt,2 Robert Brommage,1 Lindsey Buhring,1 Jean-Pierre Revelli,1 Melanie K Shadoan1 1Department of Pharmaceutical Biology, Lexicon Pharmaceuticals, Inc, The Woodlands, TX, USA; 2Depar
Autor:
David R, Powell, Deon D, Doree, Christopher M, DaCosta, Kenneth A, Platt, Robert, Brommage, Lindsey, Buhring, Jean-Pierre, Revelli, Melanie K, Shadoan
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Purpose Humans with haploinsufficiency of GPR75, an orphan GPCR, are thin. Gpr75 knockout (KO) mice are also thin with improved glucose homeostasis. We wanted to confirm these findings in Gpr75 KO mice and determine whether decreased energy intake an
Autor:
Christopher M. DaCosta, J. Wingert, Peter Vogel, Lindsey Buhring, R. Read, Melanie K. Shadoan, Gwenn M. Hansen
Publikováno v:
Veterinary Pathology. 48:642-654
Congenital generalized lipodystrophy (CGL) comprises a heterogeneous group of rare diseases associated with partial or total loss of adipose tissue. Of these, autosomal recessive Berardinelli–Seip congenital lipodystrophy (BSCL) is characterized by
Autor:
David R. Powell, Christopher M. DaCosta, Jason Gay, Zhi-Ming Ding, Melinda Smith, Jennifer Greer, Deon Doree, Sabrina Jeter-Jones, Faika Mseeh, Lawrence A. Rodriguez, Angela Harris, Lindsey Buhring, Kenneth A. Platt, Peter Vogel, Robert Brommage, Melanie K. Shadoan, Arthur T. Sands, Brian Zambrowicz
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 304(2)
Sodium-glucose cotransporter 2 (SGLT2) is the major, and SGLT1 the minor, transporter responsible for renal glucose reabsorption. Increasing urinary glucose excretion (UGE) by selectively inhibiting SGLT2 improves glycemic control in diabetic patient
Autor:
David B. Rawlins, Qingyun Liu, Amr Nouraldeen, Yiling Xie, Nicole Cathleen Goodwin, Jennifer Bardenhagen, Zheng Y. Almstead, Faika Mseeh, Christopher M. DaCosta, S. David Kimball, Jason P. Healy, Melanie K. Shadoan, Ross Mabon, David R. Powell, Alan G. E. Wilson, Lindsey Buhring, Bryce Alden Harrison
Publikováno v:
Journal of medicinal chemistry. 52(20)
The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of main