Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lindsey B. Saunders"'
Autor:
David R. Calabrese, Xiang Chen, Elena C. Leon, Snehal M. Gaikwad, Zaw Phyo, William M. Hewitt, Stephanie Alden, Thomas A. Hilimire, Fahu He, Aleksandra M. Michalowski, John K. Simmons, Lindsey B. Saunders, Shuling Zhang, Daniel Connors, Kylie J. Walters, Beverly A. Mock, John S. Schneekloth
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 stru
Externí odkaz:
https://doaj.org/article/d45674f52573447395e321fc6dc2bc80
Autor:
Beverly A. Mock, Kylie J. Walters, John K. Simmons, Shuling Zhang, Snehal M. Gaikwad, John S. Schneekloth, Elena C. Leon, Fahu He, David R. Calabrese, Daniel Connors, William M. Hewitt, Stephanie Alden, Aleksandra M. Michalowski, Thomas A. Hilimire, Zaw Phyo, Lindsey B. Saunders, Xiang Chen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce37ca6ecd2f80c8876cefec6c391f43
http://link.springer.com/article/10.1038/s41467-018-06315-w
http://link.springer.com/article/10.1038/s41467-018-06315-w
Autor:
William M. Hewitt, George T. Lountos, Katherine Zlotkowski, Samuel D. Dahlhauser, Lindsey B. Saunders, Danielle Needle, Joseph E. Tropea, Chendi Zhan, Guanghong Wei, Buyong Ma, Ruth Nussinov, David S. Waugh, John S. Schneekloth
Publikováno v:
Angewandte Chemie. 128:5797-5801
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f237e9932cc7a697e83dfca77a9ae2fb
https://doi.org/10.1002/ange.201511351
https://doi.org/10.1002/ange.201511351
Autor:
David R. Calabrese, Aleksandra M. Michalowski, John S. Schneekloth, Beverly A. Mock, Peter C. Gareiss, Elena C. Leon, Kenneth Felsenstein, Lindsey B. Saunders, Shuling Zhang, John K. Simmons
Publikováno v:
ACS Chemical Biology
The transcription factor MYC plays a pivotal role in cancer initiation, progression, and maintenance. However, it has proven difficult to develop small molecule inhibitors of MYC. One attractive route to pharmacological inhibition of MYC has been the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6fd5024ca3cfc77507a9f78fb65841
https://doi.org/10.1021/acschembio.5b00577
https://doi.org/10.1021/acschembio.5b00577
Autor:
Katherine Zlotkowski, Joseph E. Tropea, Samuel D. Dahlhauser, Guanghong Wei, William M. Hewitt, Ruth Nussinov, George T. Lountos, John S. Schneekloth, Buyong Ma, Chendi Zhan, Lindsey B. Saunders, D. Needle, David S. Waugh
Publikováno v:
Angewandte Chemie (International ed. in English). 55(19)
Conjugation of the small ubiquitin-like modifier (SUMO) to protein substrates is an important disease-associated posttranslational modification, although few inhibitors of this process are known. Herein, we report the discovery of an allosteric small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd0399528055a4c92ba875de18a3ac9
https://pubmed.ncbi.nlm.nih.gov/27038327
https://pubmed.ncbi.nlm.nih.gov/27038327
Autor:
Scott J. Miller, Lindsey B. Saunders
Publikováno v:
ACS Catalysis. 1:1347-1350
A divergent reactivity pattern of allenoates with 2,2,2-trifluoroacetophenones under Lewis base catalysis is reported. Whereas phosphine catalysis leads to a [3 + 2]-cycloaddition to form dihydrofu...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2f3a05f92b738e23033a2cd06e59ea6
https://doi.org/10.1021/cs200406d
https://doi.org/10.1021/cs200406d
Publikováno v:
Organic Letters. 12:4800-4803
Mechanistic experiments, including kinetics and hydrogen/deuterium kinetic isotope effects, reveal an "atypical" rate-determining step in a pyridylalanine-peptide catalyzed enantioselective coupling of allenoates and N-acyl imines. Typically, acrylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f793f30be232515bd483cde3802df78
https://doi.org/10.1021/ol101947s
https://doi.org/10.1021/ol101947s
Autor:
John S. Schneekloth, David R. Calabrese, Lindsey B. Saunders, Kenneth Felsenstein, Wendy Dubois, Aleksandra M. Michalowski, Shuling Zhang, John K. Simmons, Elena C. Leon, Beverly A. Mock, Frank J. Gonzalez
Publikováno v:
Cancer Research. 76:322-322
MYC overexpression or amplification is commonly seen in a wide variety of tumor types, including multiple myeloma. Although MYC appears to be an important driver of the oncogenic phenotype, the helix-loop-helix topology, short half-life, and rapid re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4921a2fc489ef60921c4a1f44e198f4
https://doi.org/10.1158/1538-7445.am2016-322
https://doi.org/10.1158/1538-7445.am2016-322
Publikováno v:
ChemInform. 40
An amine-catalyzed reaction has been discovered that couples alpha-allenic esters with N-acyl imines in good to excellent yields (up to 88%). Extension of this methodology from the study of achiral pyridine-based catalysis to chiral peptide-based sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53f93629e9003b070637f2bc93153091
https://doi.org/10.1002/chin.200940071
https://doi.org/10.1002/chin.200940071
Publikováno v:
Journal of the American Chemical Society. 131(17)
An amine-catalyzed reaction has been discovered that couples alpha-allenic esters with N-acyl imines in good to excellent yields (up to 88%). Extension of this methodology from the study of achiral pyridine-based catalysis to chiral peptide-based sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c381a3be56c1ccb3069477481fc9bde9
https://pubmed.ncbi.nlm.nih.gov/19354290
https://pubmed.ncbi.nlm.nih.gov/19354290