Výsledky vyhledávání - "Lindsey Aschenbach"

Abstract 3543: Altering tumor immunophenotypes with PD-L1 engineered toxin bodies

Autor: Swati Khanna, Elizabeth M. Kapeel, Lauren R. Byrne, Elizabeth Saputra, Steven Rivera, Lindsey Aschenbach, Lilia A. Rabia, Garrett L. Cornelison, Rachael M. Orlandella, Brigitte Brieschke, Michaela Sousares, Jay Zhao, Garrett L. Robinson, Chris Moore, Joseph D. Dekker

Publikováno v: Cancer Research. 82:3543-3543

Targeting of PD-L1 checkpoint has shown clinical efficacy in multiple solid tumor indications. Currently approved PD-L1 targeted approaches rely on the blocking activity of monoclonal antibodies (mAbs) which sterically inhibit PD-L1 thus preventing P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c2dbc19c675d76e5455c7b7a21f5cb7
https://doi.org/10.1158/1538-7445.am2022-3543

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Abstract 1628: Engineered toxin bodies targeting PD-L1 to alter tumor immunophenotypes and deliver broad antigenic diversity and patient coverage

Autor: Swati Khanna, Joseph D. Dekker, Betty Chang, Lilia A. Rabia, Garrett L. Robinson, Hilario J. Ramos, Garrett L. Cornelison, Elizabeth Saputra, Wenzhao Dong, Michaela Sousares, Jay Zhao, Lindsey Aschenbach

Publikováno v: Cancer Research. 81:1628-1628

Targeting PD-L1 has shown clinical efficacy in multiple solid tumor indications. Currently approved PD-L1 targeted approaches rely on monoclonal antibodies which sterically inhibit PD-L1 and prevent PD-1 mediated checkpoint activity. While these mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5c7c64bc122dc64e14639891733e046
https://doi.org/10.1158/1538-7445.am2021-1628

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Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core

Autor: Willy Dumont, Raphaël Frédérick, Lindsey Aschenbach, Johan Wouters, Neal Castagnoli, Cornelis J. Van der Schyf, Frederic Ooms, Alain Krief

Publikováno v: Journal of medicinal chemistry. 49(12)

The synthesis and enzyme inhibitor properties of reversible type B monoamine oxidase inhibitors are described. These compounds belong to the 5H-indeno[1,2-c]pyridazine family and possess a hydrophobic benzyloxy or 4,4,4-trifluorobutoxy side chain whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dd9e8614b20380c62fd683d4a9b04c
https://pubmed.ncbi.nlm.nih.gov/16759116

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