Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lindsey A. Doyle"'
Autor:
Lindsey A. Doyle, Brittany Takushi, Ryan D. Kibler, Lukas F. Milles, Carolina T. Orozco, Jonathan D. Jones, Sophie E. Jackson, Barry L. Stoddard, Philip Bradley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract De novo protein design methods can create proteins with folds not yet seen in nature. These methods largely focus on optimizing the compatibility between the designed sequence and the intended conformation, without explicit consideration of
Externí odkaz:
https://doaj.org/article/c5879c95398e49c699dcc9e8f2ec0118
Autor:
Sebastian Grünberg, Lindsey A. Doyle, Eric J. Wolf, Nan Dai, Ivan R. Corrêa, Erbay Yigit, Barry L. Stoddard
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/c8d65a348fc84e4d9e1f31d00e458f4b
Autor:
Jazmine P. Hallinan, Lindsey A. Doyle, Betty W. Shen, Mesfin M. Gewe, Brittany Takushi, Madison A. Kennedy, Della Friend, James M. Roberts, Philip Bradley, Barry L. Stoddard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jazmine Hallinan et al. report the development of a new generation of circular tandem repeat proteins with enhanced self-assembly. Functionalisation of these constructs with SARS CoV-2 VHH domains resulted in sub-nanomolar binding affinity to the vir
Externí odkaz:
https://doaj.org/article/11aa8d39f41348bfa35c908901de8e41
Autor:
Jason C. Klima, Lindsey A. Doyle, Justin Daho Lee, Michael Rappleye, Lauren A. Gagnon, Min Yen Lee, Emilia P. Barros, Anastassia A. Vorobieva, Jiayi Dou, Samantha Bremner, Jacob S. Quon, Cameron M. Chow, Lauren Carter, David L. Mack, Rommie E. Amaro, Joshua C. Vaughan, Andre Berndt, Barry L. Stoddard, David Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Fluorescent protein reporters based on GFP exist, but have intrinsic disadvantages. Here the authors incorporate pH, Ca2+ and protein–protein interaction sensing modalities into de novo designed mini-fluorescence-activating proteins (mFAPs), with i
Externí odkaz:
https://doaj.org/article/5f1531b0f2b14a3183076ec5a9a3c859
Autor:
Betty W Shen, Lindsey A Doyle, Rachel Werther, Abigail A Westburg, Daniel P Bies, Stephanie I Walter, Yvette A Luyten, Richard D Morgan, Barry L Stoddard, Brett K Kaiser
Publikováno v:
Nucleic Acids Research. 51:3513-3528
Bacteriophage exclusion (‘BREX’) systems are multi-protein complexes encoded by a variety of bacteria and archaea that restrict phage by an unknown mechanism. One BREX factor, termed BrxL, has been noted to display sequence similarity to various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5011618874a44a62f698a007ae96a49
https://doi.org/10.1093/nar/gkad083
https://doi.org/10.1093/nar/gkad083
Autor:
Yvette A Luyten, Deanna E Hausman, Juliana C Young, Lindsey A Doyle, Kerilyn M Higashi, Natalia C Ubilla-Rodriguez, Abigail R Lambert, Corina S Arroyo, Kevin J Forsberg, Richard D Morgan, Barry L Stoddard, Brett K Kaiser
Publikováno v:
Nucleic Acids Research. 50:5171-5190
Bacteriophage exclusion (‘BREX’) phage restriction systems are found in a wide range of bacteria. Various BREX systems encode unique combinations of proteins that usually include a site-specific methyltransferase; none appear to contain a nucleas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d133715268f6de95ab06950ce3aede26
https://doi.org/10.1093/nar/gkac311
https://doi.org/10.1093/nar/gkac311
Autor:
Yvette A. Luyten, Deanna E. Hausman, Juliana C. Young, Lindsey A. Doyle, Kerilyn M. Higashi, Natalia C. Ubilla-Rodriquez, Abigail R. Lambert, Corina S. Arroyo, Kevin J. Forsberg, Richard D. Morgan, Barry L. Stoddard, Brett K. Kaiser
Bacteriophage exclusion (‘BREX’) phage restriction systems are found in a wide range of bacteria. Various BREX systems encode unique combinations of proteins that usually include a site-specific methyltransferase; none appear to contain a nucleas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7141c56cd3afbfea1ea625bc6cd19197
https://doi.org/10.1101/2021.12.19.473356
https://doi.org/10.1101/2021.12.19.473356
Autor:
Sebastian Grünberg, Lindsey A. Doyle, Eric J. Wolf, Nan Dai, Ivan R. Corrêa, Erbay Yigit, Barry L. Stoddard
The chemical modification of RNA bases represents a ubiquitous activity that spans all domains of life. Pseudouridylation is the most common RNA modification and is observed within tRNA, rRNA, ncRNA and mRNAs. Pseudouridine synthase or ‘PUS’ enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b8b103a8140504450f8f6f6338cca07
https://doi.org/10.1101/2021.12.08.471817
https://doi.org/10.1101/2021.12.08.471817