Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Lindsey A. Allan"'
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 852-865 (2018)
Summary: Faithful chromosome segregation during mitosis depends on the spindle assembly checkpoint (SAC), which delays progression through mitosis until every chromosome has stably attached to spindle microtubules via the kinetochore. We show here th
Externí odkaz:
https://doaj.org/article/16d54de55cb743b0a53eb6a6bad385ab
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 6 (2018)
Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or c
Externí odkaz:
https://doaj.org/article/725b43a5dc1041cca045f3105b5b461d
Publikováno v:
Open Biology, Vol 5, Iss 3 (2015)
Anti-cancer drugs that disrupt mitosis inhibit cell proliferation and induce apoptosis, although the mechanisms of these responses are poorly understood. Here, we characterize a mitotic stress response that determines cell fate in response to microtu
Externí odkaz:
https://doaj.org/article/51de73097fe9429195e1b89fc5496d24
Publikováno v:
eLife, Vol 8 (2019)
PP2A-B56 is a serine/threonine phosphatase complex that regulates several major mitotic processes, including sister chromatid cohesion, kinetochore-microtubule attachment and the spindle assembly checkpoint. We show here that these key functions are
Externí odkaz:
https://doaj.org/article/dc9335a60cea4fd596dd2970fdbea044
Autor:
Andrea Corno, Marilia H Cordeiro, Lindsey A Allan, Qian Wei, Elena Harrington, Richard J Smith, Adrian T. Saurin
SUMMARYTwo major mechanisms have evolved to safeguard genome stability during mitosis: the mitotic checkpoint delays mitosis until all chromosomes have attached to microtubules, and the kinetochore-microtubule error-correction pathway keeps this atta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3051a80cd543aa0edaa0626004e9548f
https://doi.org/10.1101/2022.05.22.492960
https://doi.org/10.1101/2022.05.22.492960
Autor:
Giuseppe Ciossani, Magda Camacho Reis, Lindsey A. Allan, Geert J. P. L. Kops, Sabine Wohlgemuth, Adrian T. Saurin, Pim J. Huigs in ‘t Veld, Andrea Musacchio
Publikováno v:
The EMBO Journal
EMBO Journal, 39(12). Nature Publishing Group
EMBO Journal, 39(12). Nature Publishing Group
Cyclin B:CDK1 is the master kinase regulator of mitosis. We show here that, in addition to its kinase functions, mammalian Cyclin B also scaffolds a localised signalling pathway to help preserve genome stability. Cyclin B1 localises to an expanded re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433103395e791b8dee108e712a049443
https://doi.org/10.15252/embj.2019103180
https://doi.org/10.15252/embj.2019103180
Autor:
Trisha V. Vigneswaran, Ranjit Akolekar, Argyro Syngelaki, Vita Zidere, Marietta Charakida, Lindsey D. Allan, John M. Simpson, Kypros H. Nicolaides
Publikováno v:
Journal of the American Society of Echocardiography. 34:1007-1016.e10
Background Doppler assessment of ventricular filling and outflow tract velocities is an integral part of fetal echocardiography, to assess diastolic function, systolic function, and outflow tract obstruction. There is a paucity of prospective data fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0b63081ee88aeae31bed774f7f7363
https://doi.org/10.1016/j.echo.2021.04.017
https://doi.org/10.1016/j.echo.2021.04.017
Autor:
Pim J. Huigs in ‘t Veld, Andrea Musacchio, Geert J. P. L. Kops, Magda Camacho Reis, Lindsey A. Allan, Liu Y, Adrian T. Saurin
The Cyclin B:CDK1 kinase complex is the master regulator of mitosis that phosphorylates hundreds of proteins to coordinate mitotic progression. We show here that, in addition to these kinase functions, Cyclin B also scaffolds a localised signalling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a6eccfe52cdb2585ea5e4e5f8f05ee
https://doi.org/10.1101/726224
https://doi.org/10.1101/726224