Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lindsey A Carfrae"'
Autor:
Chun Kew, Cristian Prieto-Garcia, Anshu Bhattacharya, Manuela Tietgen, Craig R. MacNair, Lindsey A. Carfrae, João Mello-Vieira, Stephan Klatt, Yi-Lin Cheng, Rajeshwari Rathore, Elise Gradhand, Ingrid Fleming, Man-Wah Tan, Stephan Göttig, Volkhard A. J. Kempf, Ivan Dikic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Acinetobacter baumannii is a pathogenic and multidrug-resistant Gram-negative bacterium that causes severe nosocomial infections. To better understand the mechanism of pathogenesis, we compare the proteomes of uninfected and infected human c
Externí odkaz:
https://doaj.org/article/cc857566b9914285a523bd2ab2b86cfe
Autor:
Lindsey A. Carfrae, Eric D. Brown
Publikováno v:
Trends in Microbiology. 31:571-585
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e989a8c0762f8ee8293b95fbbce1276c
https://doi.org/10.1016/j.tim.2023.01.002
https://doi.org/10.1016/j.tim.2023.01.002
Autor:
Craig R. MacNair, Jonathan M. Stokes, Lindsey A. Carfrae, Aline A. Fiebig-Comyn, Brian K. Coombes, Michael R. Mulvey, Eric D. Brown
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The plasmid-borne mcr-1 gene confers resistance to the antibiotic colistin. Here, MacNair et al. show that mcr-1 positive bacteria are however susceptible to colistin-mediated disruption of the outer membrane, and can be killed in vitro and in vivo b
Externí odkaz:
https://doaj.org/article/da87016d954b431591b5fc0f923e52e7
Autor:
Lindsey A. Carfrae, Kenneth Rachwalski, Shawn French, Rodion Gordzevich, Laura Seidel, Caressa N. Tsai, Megan M. Tu, Craig R. MacNair, Olga G. Ovchinnikova, Bradley R. Clarke, Chris Whitfield, Eric D. Brown
Publikováno v:
Nature Microbiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d6b82e52a7bb6a76e755becb078789
https://doi.org/10.1038/s41564-023-01369-z
https://doi.org/10.1038/s41564-023-01369-z
Autor:
Brian P Alcock, William Huynh, Romeo Chalil, Keaton W Smith, Amogelang R Raphenya, Mateusz A Wlodarski, Arman Edalatmand, Aaron Petkau, Sohaib A Syed, Kara K Tsang, Sheridan J C Baker, Mugdha Dave, Madeline C McCarthy, Karyn M Mukiri, Jalees A Nasir, Bahar Golbon, Hamna Imtiaz, Xingjian Jiang, Komal Kaur, Megan Kwong, Zi Cheng Liang, Keyu C Niu, Prabakar Shan, Jasmine Y J Yang, Kristen L Gray, Gemma R Hoad, Baofeng Jia, Timsy Bhando, Lindsey A Carfrae, Maya A Farha, Shawn French, Rodion Gordzevich, Kenneth Rachwalski, Megan M Tu, Emily Bordeleau, Damion Dooley, Emma Griffiths, Haley L Zubyk, Eric D Brown, Finlay Maguire, Robert G Beiko, William W L Hsiao, Fiona S L Brinkman, Gary Van Domselaar, Andrew G McArthur
Publikováno v:
Nucleic acids research.
The Comprehensive Antibiotic Resistance Database (CARD; card.mcmaster.ca) combines the Antibiotic Resistance Ontology (ARO) with curated AMR gene (ARG) sequences and resistance-conferring mutations to provide an informatics framework for annotation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fc299cd5e8184133784ff0a1dd7dca
https://pubmed.ncbi.nlm.nih.gov/36263822
https://pubmed.ncbi.nlm.nih.gov/36263822
Autor:
Brent S. Weber, Lindsey A. Carfrae, Joshua J. Woods, Kristina Klobucar, Nicholas P. Bigham, Craig R. MacNair, Tracy L. Raivio, Justin J. Wilson, Eric D. Brown
There is an urgent need to develop new antibiotics for the treatment of infections caused by drug-resistant Gram-negative bacteria. In particular, new and diverse chemical classes of antibiotics are needed, as most antibiotics in clinical development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a71490eda9ea2a61505dd2e4052959c0
https://doi.org/10.1101/2022.08.11.503708
https://doi.org/10.1101/2022.08.11.503708
Autor:
Andrew G. McArthur, Craig R. MacNair, Hiu-Ki R Tran, Lindsey A. Carfrae, Eric D. Brown, Sara S. El Zahed, Michael J. Ellis, Maya A. Farha
Publikováno v:
ACS Infectious Diseases. 6:2709-2718
The growing challenge of microbial resistance emphasizes the importance of new antibiotics or reviving strategies for the use of old ones. Macrolide antibiotics are potent bacterial protein synthesis inhibitors with a formidable capacity to treat lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550c467959dcfee020c555beb41a3cc1
https://doi.org/10.1021/acsinfecdis.0c00340
https://doi.org/10.1021/acsinfecdis.0c00340
Autor:
Maya A. Farha, Lindsey A. Carfrae, Nicholas G. Jentsch, Jakob Magolan, Craig R. MacNair, Omar M. El-Halfawy, Eric D. Brown, Robert T. Gale, Xiong Zhang
Publikováno v:
ACS Infectious Diseases. 6:338-346
The spread of antimicrobial resistance continues to be a priority health concern worldwide, necessitating exploration of alternative therapies. Cannabis sativa has long been known to contain antibacterial cannabinoids, but their potential to address
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f973ffea8c2fcd19160c257eaee23210
https://doi.org/10.1021/acsinfecdis.9b00419
https://doi.org/10.1021/acsinfecdis.9b00419
Autor:
Kyle Swanson, Lindsey A. Carfrae, Eric D. Brown, Jonathan M. Stokes, Kevin Yang, Anush Chiappino-Pepe, George M. Church, Tommi S. Jaakkola, Zohar Bloom-Ackermann, Victoria M. Tran, Regina Barzilay, Craig R. MacNair, James J. Collins, Shawn French, Andres Cubillos-Ruiz, Nina M. Donghia, Ian W. Andrews, Ahmed H. Badran, Wengong Jin, Emma J. Chory
Publikováno v:
Cell
Prof. Collins via Howard Silver
Prof. Collins via Howard Silver
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3644902a137a3f94eaca8153af34f0d
https://europepmc.org/articles/PMC8349178/
https://europepmc.org/articles/PMC8349178/
Autor:
Christopher M Brown, Murray S. Junop, Lindsey A. Carfrae, Brent S. Weber, Brian K. Coombes, Vishwas N Rao, Joshua Chun, Soumaya Zlitni, Eric D. Brown, Craig R. MacNair, Caressa N. Tsai
Publikováno v:
Nature microbiology. 5(1)
To revitalize the antibiotic pipeline, it is critical to identify and validate new antimicrobial targets1. In Mycobacteria tuberculosis and Francisella tularensis, biotin biosynthesis is a key fitness determinant during infection2-5, making it a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a20fd0424a3ee7e6897c54e5a49e05
https://pubmed.ncbi.nlm.nih.gov/31659298
https://pubmed.ncbi.nlm.nih.gov/31659298