MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastoma.

Autor: Adiamah M; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Poole B; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Lindsey JC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Kohe S; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Morcavallo A; Division of Clinical Studies, Institute of Cancer Research (ICR), London and Royal Marsden NHS Trust, Sutton, UK., Burté F; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Hill RM; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Blair H; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Thompson D; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Singh M; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Swartz S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Crosier S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Zhang T; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Maddocks ODK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Peet A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Chesler L; Division of Clinical Studies, Institute of Cancer Research (ICR), London and Royal Marsden NHS Trust, Sutton, UK., Hickson I; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Maxwell RJ; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK., Clifford SC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK.

Publikováno v: Neuro-oncology [Neuro Oncol] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.

The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second-generation subtypes.

Autor: Hicks D; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Rafiee G; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; School of Electronics, Electrical Engineering and Computer Science, Queen's University Belfast, Belfast, UK., Schwalbe EC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK., Howell CI; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Lindsey JC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Hill RM; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Smith AJ; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Adidharma P; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Steel C; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Richardson S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Pease L; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Danilenko M; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Crosier S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Joshi A; Department of Neuropathology, Royal Victoria Infirmary, Newcastle University Teaching Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Wharton SB; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK., Jacques TS; Great Ormond Street Hospital, London, UK., Pizer B; Institute of Translational Research, University of Liverpool, Liverpool, UK., Michalski A; Great Ormond Street Hospital, London, UK., Williamson D; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Bailey S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Clifford SC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Publikováno v: Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2021 Feb; Vol. 47 (2), pp. 236-250. Date of Electronic Publication: 2020 Sep 01.

Randomized Controlled Trial of a Remote Coaching mHealth Adherence Intervention in Youth Living with HIV.

Autor: Amico KR; Department of Health Behavior and Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA. ramico@umich.edu., Lindsey JC; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hudgens M; Department of Biostatistics, Collaborative Studies Coordinating Center, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dallas R; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Horvath KJ; Department of Clinical Psychology, San Diego State University, San Diego, CA, USA., Dunlap A; Department of Health Behavior and Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA., Goolsby R; Department of Biostatistics, Collaborative Studies Coordinating Center, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Johnson MM; Department of Health Behavior and Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA., Heckman B; Frontier Science and Technology Research Foundation, Amherst, NY, USA., Crawford J; Department of Health Behavior and Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA., Secord E; Wayne State University, Detroit, MI, USA., Purswani M; BronxCare Health System, Bronx, NY, USA., Reirden D; Children's Hospital Colorado, University of Colorado Denver, Denver, CO, USA., Rathore M; Education and Service (UF CARES), University of Florida Center for HIV/AIDS Research, Jacksonville, FL, USA., Robinson LG; South Florida CDTC, Ft. Lauderdale, FL, USA., Gaur AH; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.

Publikováno v: AIDS and behavior [AIDS Behav] 2022 Dec; Vol. 26 (12), pp. 3897-3913. Date of Electronic Publication: 2022 Jun 07.

Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development.

Autor: Williamson D; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK. Electronic address: daniel.williamson@newcastle.ac.uk., Schwalbe EC; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK., Hicks D; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Aldinger KA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Lindsey JC; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Crosier S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Richardson S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Goddard J; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Hill RM; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Castle J; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Grabovska Y; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK; Division of Molecular Pathology, Institute of Cancer Research, London, UK., Hacking J; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Pizer B; Institute of Translational Research, University of Liverpool, Liverpool, UK., Wharton SB; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK., Jacques TS; Developmental Biology and Cancer Programme, UCL GOS Institute of Child Health, London, and Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Joshi A; Department of Neuropathology, Royal Victoria Infirmary (RVI), Newcastle University Teaching Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Bailey S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Clifford SC; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK. Electronic address: steve.clifford@newcastle.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2022 Aug 02; Vol. 40 (5), pp. 111162.

Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse.

Autor: Richardson S; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Hill RM; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Kui C; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Lindsey JC; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Grabovksa Y; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Keeling C; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Pease L; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Bashton M; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.; The Hub for Biotechnology in the Built Environment, Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK., Crosier S; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Vinci M; Department of Onco-Haematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy., André N; Department of Pediatric Hematology and Oncology, AP-HM, Marseille,France.; Institute of NeuroPhysiopathology, Aix-Marseille Universite, CNRS, Marseille, France., Figarella-Branger D; CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, AP-HM, Marseille, France.; Children's Cancer Centre, Royal Children's Hospital, Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Hansford JR; Children's Cancer Centre, Royal Children's Hospital, Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Lastowska M; Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland., Zakrzewski K; Department of Neurosurgery, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland., Jorgensen M; Department of Haematology and Oncology, Great Ormond Street Hospital for Children, London, UK., Pickles JC; Department of Histopathology, Great Ormond Street Hospital for Children, London, UK.; Developmental Biology and Cancer Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK., Taylor MD; Programme in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany., Wharton SB; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK., Pizer B; Oncology Unit, Alder Hey Children's Hospital, Liverpool, UK., Michalski A; Department of Haematology and Oncology, Great Ormond Street Hospital for Children, London, UK., Joshi A; Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Jacques TS; Department of Histopathology, Great Ormond Street Hospital for Children, London, UK.; Developmental Biology and Cancer Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK., Hicks D; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Schwalbe EC; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK., Williamson D; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Ramaswamy V; Programme in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Bailey S; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Clifford SC; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.

Publikováno v: Neuro-oncology [Neuro Oncol] 2022 Jan 05; Vol. 24 (1), pp. 153-165.