Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lindsey, Crowley"'
Autor:
Samantha M. Goodstal, Jing Lin, Timothy Crandall, Lindsey Crowley, Andrew T. Bender, Albertina Pereira, Maria Soloviev, John S. Wesolowski, Riham Iadevaia, Sven-Eric Schelhorn, Edith Ross, Federica Morandi, Jianguo Ma, Anderson Clark
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract TL-895 (formerly known as M7583) is a potent, highly selective, adenosine triphosphate (ATP)-competitive, second-generation, irreversible inhibitor of Bruton’s tyrosine kinase (BTK). We characterized its biochemical and cellular effects in
Externí odkaz:
https://doaj.org/article/e3ad94d227854b95ac72302c616828df
Autor:
Shota Fukuoka, Yoshikatsu Koga, Mayumi Yamauchi, Shigehiro Koganemaru, Masahiro Yasunaga, Kohei Shitara, Toshihiko Doi, Takayuki Yoshino, Toshio Kuronita, Brian Elenbaas, Pamela Wahra, Hong Zhang, Lindsey Crowley, Molly H. Jenkins, Anderson Clark, Takashi Kojima
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The PI3K-Akt-mTOR (PAM) pathway is implicated in tumor progression in many tumor types, including metastatic gastric cancer (GC). The initial promise of PAM inhibitors has been unrealized in the clinic, presumably due, in part, to the up-reg
Externí odkaz:
https://doaj.org/article/f0c48d0b34094711b83db45840b8cc94
Autor:
Manja, Friese-Hamim, Anderson, Clark, Dominique, Perrin, Lindsey, Crowley, Christof, Reusch, Olga, Bogatyrova, Hong, Zhang, Timothy, Crandall, Jing, Lin, Jianguo, Ma, David, Bachner, Jürgen, Schmidt, Martin, Schaefer, Christopher, Stroh
Publikováno v:
Lung Cancer. 163:77-86
Central nervous system-penetrant therapies with intracranial efficacy against non-small cell lung cancer (NSCLC) brain metastases are urgently needed. We report preclinical studies investigating brain penetration and intracranial activity of the MET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6251c962bc1d7af754da95a0bf7ce932
https://doi.org/10.1016/j.lungcan.2021.11.020
https://doi.org/10.1016/j.lungcan.2021.11.020
Autor:
Brian H. Heasley, Jing Lin, Thomas F. N. Haxell, Igor Mochalkin, Constantin Neagu, Felix Rohdich, Ruoxi Lan, Amanda E. Sutton, Jennifer Jackson, Potnick Justin, Bayard R. Huck, Andreas Machl, Katrin Georgi, Xiaoling Chen, Sherer Brian A, Erik Wilker, Thomas E. Richardson, Anderson Clark, Reinaldo Jones, Johnson Theresa L, Lizbeth Celeste Deselm, Andreas Goutopoulos, Hui Tian, Yufang Xiao, Joseph A. Moore, Lindsey Crowley
Publikováno v:
Journal of Medicinal Chemistry. 64:14603-14619
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0f668e1b7d0d3fdf120a40211a6894
https://doi.org/10.1021/acs.jmedchem.1c01087
https://doi.org/10.1021/acs.jmedchem.1c01087
Autor:
Andrzej Gondela, Marcin Leś, Maciej Mikulski, Łukasz Włoszczak, Frank Becker, Kamila Olech, Shivapriya Ramaswamy, Marcin Król, Henryk Pawlik, Christian Herhaus, Jose Alvarez, Joanna Szczęśniak, Heike Schilke, Paulina Niedziejko, Lindsey Crowley, Roberta Ferretti, Mireille Krier, Pamela Wahra, Pia Böpple, Timo Heinrich, Justyna Martyka, Ewa Sitek, Karol Zuchowicz, Ada Sala-Hojman, Anna Bartosik, Stefano Minguzzi, Łukasz Dudek, Frank Czauderna, Mateusz Nowak, Ansgar Wegener, Michal Galezowski, Carl Petersson, Sven Jäckel
Publikováno v:
Journal of medicinal chemistry. 64(16)
Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d3f6d43a88e3759b7bf441af1e7dd6
https://pubmed.ncbi.nlm.nih.gov/34382802
https://pubmed.ncbi.nlm.nih.gov/34382802
Autor:
Brian Elenbaas, Arman Esfandiari, Francesca Vena, Lindsey Crowley, Samantha Goodstal, John A. Hartley, Manuel Rodriguez-Justo, Ruochen Jia, Sakeena Syed, Juan Jose Garcia-Gomez, Jianguo Ma, Daniel Hochhauser
Publikováno v:
Oncotarget
// Francesca Vena 1, * , Ruochen Jia 1, * , Arman Esfandiari 1 , Juan J. Garcia-Gomez 1 , Manuel Rodriguez-Justo 2 , Jianguo Ma 3 , Sakeena Syed 3 , Lindsey Crowley 3 , Brian Elenbaas 3 , Samantha Goodstal 3 , John A. Hartley 1 and Daniel Hochhauser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c433fc4f71eed04ce7eded897bf7070
http://europepmc.org/articles/PMC5837749
http://europepmc.org/articles/PMC5837749
Autor:
Pedro, Exman, Ana C, Garrido-Castro, Melissa E, Hughes, Rachel A, Freedman, Tianyu, Li, Lorenzo, Trippa, Brittany L, Bychkovsky, Romualdo, Barroso-Sousa, Simona, Di Lascio, Colin, Mackichan, Max R, Lloyd, Max, Krevalin, Ethan, Cerami, Margaret S, Merrill, Rebecca, Santiago, Lindsey, Crowley, Nicole, Kuhnly, Janet, Files, Neal I, Lindeman, Laura E, MacConaill, Priti, Kumari, Sara M, Tolaney, Ian E, Krop, Ron, Bose, Bruce E, Johnson, Cynthia X, Ma, Deborah A, Dillon, Eric P, Winer, Nikhil, Wagle, Nancy U, Lin
Publikováno v:
JCO Precis Oncol
PURPOSE: The yield of comprehensive genomic profiling in recruiting patients to molecular-based trials designed for small subgroups has not been fully evaluated. We evaluated the likelihood of enrollment in a clinical trial that required the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b24ea3fa67a8103df2c30d1c25884d4c
https://pubmed.ncbi.nlm.nih.gov/32923853
https://pubmed.ncbi.nlm.nih.gov/32923853
Autor:
Claudia Wilm, Christopher Stroh, Jing Lin, Anderson Clark, Martin Schaefer, David Bachner, Christof Reusch, Jürgen Schmidt, Hong Zhang, Olga Bogatyrova, Lindsey Crowley, Jianguo Ma, Timothy Crandall, Manja Friese-Hamim
Publikováno v:
Cancer Research. 80:3407-3407
Background Patients with advanced non-small cell lung cancer (NSCLC) harboring oncogenic MET alterations, such as MET exon 14 skipping or MET amplification (MET amp), benefit from MET tyrosine kinase inhibitor (TKI) treatment. Brain metastases are co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1a49b499dff7e3e850973a53ea1fac4
https://doi.org/10.1158/1538-7445.am2020-3407
https://doi.org/10.1158/1538-7445.am2020-3407
Autor:
Sakeena Syed, Lindsey Crowley, Janet Ogden, Jamie Shaw, Jianguo Ma, Brian Elenbaas, Samantha Goodstal
Publikováno v:
Cancer Research. 75:2603-2603
The efficacy and tolerability of the MEK inhibitor Pimasertib and the hypoxia-activated prodrug TH-302 combination were explored in pancreatic and biliary tract preclinical tumor xenograft models. These studies were based on the hypotheses that combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61cd16af28d6c8cddcfd532094e0809a
https://doi.org/10.1158/1538-7445.am2015-2603
https://doi.org/10.1158/1538-7445.am2015-2603