One-Step Regioselective Synthesis of N-1-Substituted Dihydrouracils: A Motif of Growing Popularity in the Targeted Protein Degradation Field.

Autor: Nixon IDG; Medicinal Chemistry, Oncology R&D, AstraZeneca, Charter Way, Macclesfield SK10 2NA, United Kingdom., Bateman JM; Medicinal Chemistry, Oncology R&D, AstraZeneca, The Discovery Centre, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Michaelides IN; Hit Discovery, Oncology R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom., Fairley G; Medicinal Chemistry, Oncology R&D, AstraZeneca, Charter Way, Macclesfield SK10 2NA, United Kingdom., Pemberton MJ; Medicinal Chemistry, Oncology R&D, AstraZeneca, The Discovery Centre, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Braybrooke EL; Medicinal Chemistry, Oncology R&D, AstraZeneca, The Discovery Centre, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Sutton K; Medicinal Chemistry, Oncology R&D, AstraZeneca, Charter Way, Macclesfield SK10 2NA, United Kingdom., Lindsay-Scott PJ; Medicinal Chemistry, Oncology R&D, AstraZeneca, The Discovery Centre, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2024 Dec 20; Vol. 89 (24), pp. 18301-18312. Date of Electronic Publication: 2024 Dec 10.

PET ligands [ ¹⁸ F]LSN3316612 and [ ¹¹ C]LSN3316612 quantify O -linked-β- N -acetyl-glucosamine hydrolase in the brain.

Autor: Lu S; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA., Haskali MB; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA., Ruley KM; Eli Lilly and Co, Indianapolis, IN 46285, USA., Dreyfus NJ; Eli Lilly and Co, Windlesham GU20 6PH, UK., DuBois SL; Eli Lilly and Co, Indianapolis, IN 46285, USA., Paul S; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA., Liow JS; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA., Morse CL; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA., Kowalski A; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA., Gladding RL; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA., Gilmore J; Eli Lilly and Co, Windlesham GU20 6PH, UK., Mogg AJ; Eli Lilly and Co, Windlesham GU20 6PH, UK., Morin SM; Eli Lilly and Co, Indianapolis, IN 46285, USA., Lindsay-Scott PJ; Eli Lilly and Co, Windlesham GU20 6PH, UK., Ruble JC; Eli Lilly and Co, Indianapolis, IN 46285, USA., Kant NA; Eli Lilly and Co, Indianapolis, IN 46285, USA., Shcherbinin S; Eli Lilly and Co, Indianapolis, IN 46285, USA., Barth VN; Eli Lilly and Co, Indianapolis, IN 46285, USA., Johnson MP; Eli Lilly and Co, Indianapolis, IN 46285, USA., Cuadrado M; Lilly, S. A. Avenida de la Industria 30, 28108 Alcobendas, Madrid, Spain., Jambrina E; Lilly, S. A. Avenida de la Industria 30, 28108 Alcobendas, Madrid, Spain., Mannes AJ; Department of Perioperative Medicine, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1510, USA., Nuthall HN; Eli Lilly and Co, Windlesham GU20 6PH, UK., Zoghbi SS; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA., Jesudason CD; Eli Lilly and Co, Indianapolis, IN 46285, USA., Innis RB; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA., Pike VW; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA. pikev@mail.nih.gov.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 May 13; Vol. 12 (543).

Transition-Metal-Free Reductive Hydroxymethylation of Isoquinolines.

Autor: Reeves BM; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK., Hepburn HB; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK., Grozavu A; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK., Lindsay-Scott PJ; Eli Lilly and Company, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK., Donohoe TJ; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Oct 28; Vol. 58 (44), pp. 15697-15701. Date of Electronic Publication: 2019 Sep 24.

A Flexible Strategy for the Regiocontrolled Synthesis of Pyrazolo[1,5-a]pyrazines.

Autor: Lindsay-Scott PJ; Eli Lilly and Company Limited, Erl Wood Manor, Windlesham, Surrey GU20 6PH, United Kingdom., Charlesworth NG; Eli Lilly and Company Limited, Erl Wood Manor, Windlesham, Surrey GU20 6PH, United Kingdom., Grozavu A; Eli Lilly and Company Limited, Erl Wood Manor, Windlesham, Surrey GU20 6PH, United Kingdom.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2017 Oct 20; Vol. 82 (20), pp. 11295-11303. Date of Electronic Publication: 2017 Oct 03.

Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin.

Autor: Nicolaou KC; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. kcn@scripps.edu, Jiang X, Lindsay-Scott PJ, Corbu A, Yamashiro S, Bacconi A, Fowler VM

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2011 Feb 01; Vol. 50 (5), pp. 1139-44. Date of Electronic Publication: 2011 Jan 07.