Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lindsay Webb"'
Autor:
Jian Ding, Robert Hofmeister, Robert Tighe, Michelle Fleury, Derrick McCarthy, Holly Horton, Courtney Anderson, Amy Watt, Adam Zieba, Lindsay Webb, Dario Gutierrez
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/d44cfb388e964e529dc5269efe101901
Autor:
Jacques Moisan, Chunxiao Xu, Amit Deshpande, Joern-Peter Halle, Neil Brewis, Lindsay Webb, Brain Rabinovich, Xueyuan Zhou, Frederic Christian Pipp, Rene Schweickhardt, Sireesha Yalavarthi, Clotilde Bourin, Payel Ghatak, Barroq Safi, Francisca Wollerton, Jose Munoz-Olaya, Natalya Belousova, Marat Alimzhanov, Martina Hubensack, Andree Blaukat
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/ac03000f810b45d7aff318ced96b4000
Autor:
Amit Deshpande, Barroq Safi, Martina Hubensack, Lindsay Webb, Rene Schweickhardt, Natalya Belousova, Payel Ghatak, Francisca Wollerton, Joern-Peter Halle, Marat Alimzhanov, Frederic Christian Pipp, Jacques Moisan, Brain Rabinovich, Neil Brewis, Xueyuan Zhou, Andree Blaukat, Chunxiao Xu, Jose Munoz-Olaya, Clotilde Bourin, Sireesha Yalavarthi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundThe costimulatory receptor CD137 (also known as 4-1BB and TNFRSF9) plays an important role in sustaining effective cytotoxic T cell immune responses and its agonism has been investigated as a cancer immunotherapy. In clinical trials, the sy
Autor:
Michelle Fleury, Amy Watt, Lindsay Webb, Holly M. Horton, Robert Tighe, Robert Hofmeister, Derrick McCarthy, Courtney Anderson, Jian Ding, Dario A. Gutierrez, Adam Zieba
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundAdoptive cell therapies have shown great promise in hematological malignancies but have yielded little progress in the context of solid tumors. We have developed T cell receptor fusion construct (TRuC®) T cells, which are equipped with an
Autor:
Dong Zhang, Christie A. Kelton, Zhouxiang Chen, Clotilde Bourin, Hong Wang, Sireesha Yalavarthi, Chunxiao Xu, Lindsay Webb, Natalya Belousova, Joern-Peter Halle, Andree Blaukat, Jacques Moisan, Hui Huang, Feng Jiang
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A351-A352
BackgroundM6223 is a fully human antagonistic anti-T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) antibody in IgG1 format with Fc-mediated effector function.MethodsThe ability of M6223 to block the interaction of TIGIT with its li
Publikováno v:
Cancer Immunology Research. 10:P077-P077
CD4 T cells include multiple sublineages orchestrating a broad range of effector activities during the initiation, promotion, and progression of carcinogenesis. Although regulatory T cells (Tregs) are well-characterized to promote tumor progression,
Autor:
Robert Hofmeister, Robert Tighe, Jian Ding, Adam Zieba, Holly M. Horton, Dario A. Gutierrez, Troy D. Patterson, Lindsay Webb, Michelle Fleury
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A214-A214
BackgroundAdoptive cell therapies have shown great promise in hematological malignancies. To realize the potential of T cell therapies in solid tumors, we have developed T cell receptor fusion construct (TRuC®) T cells, which are equipped with an en
Autor:
Mireia Guerau-De-Arellano, Shouvonik Sengupta, Stephanie Amici, Lindsay Webb, Kelly Weiss, Kewal Asosingh
Publikováno v:
The Journal of Immunology. 202:119.6-119.6
Severe asthma affects 2.4 million Americans and 23.8 million people worldwide and accounts for the majority of total asthma hospital costs. Most severe asthma is mediated by Th17/neutrophilic responses, alone or combined with Th2 and/or Th1 responses
Autor:
Shouvonik Sengupta, Lindsay Webb, Janiret Narvaez-Miranda, Stephanie Amici, Gregory Nagy, Mireia Guerau-De-Arellano
Publikováno v:
The Journal of Immunology. 202:186.9-186.9
Multiple sclerosis (MS) is a debilitating autoimmune disease of the central nervous system (CNS) mediated by CD4+ T cells. Clinical data has provided evidence that MS patient T cells display an activated or memory phenotype and genome-wide associatio
Autor:
Mireia Guerau-De-Arellano, Kyle Jablonski, Stephanie A. Amici, Andrew Gaudet, Phillip G. Popovich, Lindsay Webb
Publikováno v:
The Journal of Immunology. 196:202.16-202.16
Classically (M1) and alternatively activated (M2) macrophages play distinct roles in various physiological and disease processes. M1 responses can cause inflammatory disease and tissue damage while M2 macrophages can limit inflammation and promote ti