Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lindsay Stimson"'
Autor:
Paul Workman, Michael Waterfield, Al Burlingame, Michael Walton, Joanne Salmons, Emmanuel deBilly, Marissa Powers, Swee Sharp, Ian Judson, Udai Banerji, Wynne Aherne, Lindsay Stimson, Rainer Cramer, Marketa Zvelebil, Alice Yang, Akunna Akpan, Jens-Oliver Koopman, Rob Stein, Soren Naaby-Hansen, Paul A. Clarke, Alison Maloney
Supplementary Data URL from Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4b4ebae9087b2c2c46e29324919a96
https://doi.org/10.1158/0008-5472.22368576.v1
https://doi.org/10.1158/0008-5472.22368576.v1
Autor:
Paul Workman, Michael Waterfield, Al Burlingame, Michael Walton, Joanne Salmons, Emmanuel deBilly, Marissa Powers, Swee Sharp, Ian Judson, Udai Banerji, Wynne Aherne, Lindsay Stimson, Rainer Cramer, Marketa Zvelebil, Alice Yang, Akunna Akpan, Jens-Oliver Koopman, Rob Stein, Soren Naaby-Hansen, Paul A. Clarke, Alison Maloney
Supplementary Figure 1 from Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1456e7090b27bfeb595dd22afa87203f
https://doi.org/10.1158/0008-5472.22368573
https://doi.org/10.1158/0008-5472.22368573
Autor:
Paul Workman, Michael Waterfield, Al Burlingame, Michael Walton, Joanne Salmons, Emmanuel deBilly, Marissa Powers, Swee Sharp, Ian Judson, Udai Banerji, Wynne Aherne, Lindsay Stimson, Rainer Cramer, Marketa Zvelebil, Alice Yang, Akunna Akpan, Jens-Oliver Koopman, Rob Stein, Soren Naaby-Hansen, Paul A. Clarke, Alison Maloney
The promising antitumor activity of 17-allylamino-17-demethoxygeldanamycin (17AAG) results from inhibition of the molecular chaperone heat shock protein 90 (HSP90) and subsequent degradation of multiple oncogenic client proteins. Gene expression micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e8d9964da35d5835cf227d7436ec80
https://doi.org/10.1158/0008-5472.c.6496011.v1
https://doi.org/10.1158/0008-5472.c.6496011.v1
Autor:
Joanna F. McGouran, Dermot Kerr, Omar Khan, Lindsay Stimson, Amanda S. Coutts, Heidi Olzscha, Geng Liu, Mark R. Middleton, Maria I. New, N B La Thangue, Benedikt M. Kessler
Histone deacetylase (HDAC) is an emergent anticancer target, and HR23B is a biomarker for response to HDAC inhibitors. We show here that HR23B has impacts on two documented effects of HDAC inhibitors; HDAC inhibitors cause apoptosis in cells expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1ff7c330fe7f80fca6bb7be29be454
https://doi.org/10.1038/cdd.2013.47
https://doi.org/10.1038/cdd.2013.47
Autor:
Joanna F. McGouran, Omar Khan, Lindsay Stimson, Nicholas B. La Thangue, Geng Liu, Simon M. Carr, Shonagh Munro, Jutta Moehlenbrink, Er Chieh Cho, Amanda S. Coutts, Yi Chien Lu, Rebecca Konietzny, David J. Kerr, Shunsheng Zheng, Benedikt M. Kessler
Publikováno v:
The EMBO Journal. 31:1785-1797
E2F transcription factors are implicated in diverse cellular functions. The founding member, E2F-1, is endowed with contradictory activities, being able to promote cell-cycle progression and induce apoptosis. However, the mechanisms that underlie the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38f179b22402807e61f53c09a67cdc2a
https://doi.org/10.1038/emboj.2012.17
https://doi.org/10.1038/emboj.2012.17
Autor:
Martin G. Rowlands, David Festus Charles Moffat, Lindsay Stimson, Vanessa L. Clark, Lindsey Ann Needham, Francesca Ann Day, Anthea Hardcastle, Judata Wibata, Sue Eccles, Deborah McNamara, Sanjay Patel, A. Donald, Wynne Aherne, Florence I. Raynaud
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6657-6660
Inhibition of histone deacetylase activity represents a promising new modality in the treatment of a number of cancers. A novel HDAC series demonstrating inhibitory activity in cell proliferation assays is described. Optimisation based on the introdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39718494ed048094fc341c760146382e
https://doi.org/10.1016/j.bmcl.2010.09.016
https://doi.org/10.1016/j.bmcl.2010.09.016
Autor:
Nicola F. Smith, Tony Kouzarides, Lindsay Stimson, Andrew J. Bannister, Paul Workman, Paul Rogers, Martin G. Rowlands, G. Wynne Aherne, Florence I. Raynaud, Michael Jarman, Vassilios Bavetsias, Yvette Newbatt, Stephen Gorsuch, Edward McDonald
Publikováno v:
Molecular Cancer Therapeutics. 4:1521-1532
Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e905716a304e638e8ae7ea2c5447b8d
https://doi.org/10.1158/1535-7163.mct-05-0135
https://doi.org/10.1158/1535-7163.mct-05-0135
Publikováno v:
Expert Opinion on Emerging Drugs. 9:135-154
In eukaryotes, genomic DNA is packaged with histone proteins into the cell nucleus as chromatin, condensing the DNA10,000-fold. Chromatin is highly dynamic and exerts profound control on gene expression. Localised chromatin decondensation facilitates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4468694ab4ce6e7c9dac83bb65da1144
https://doi.org/10.1517/14728214.9.1.135
https://doi.org/10.1517/14728214.9.1.135
Publikováno v:
Methods. 26:245-253
There is presently enormous interest in the function and regulatory roles of histone acetyltransferase enzymes. Along with deacetylases it is now evident that these enzymes play a key role in many cellular processes including chromatin remodeling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b4febafecb51ca3c8abe5e59d396d8
https://doi.org/10.1016/s1046-2023(02)00028-2
https://doi.org/10.1016/s1046-2023(02)00028-2
Autor:
Martin G. Rowlands, Deborah H. Brotherton, Paul N. Mortenson, David Festus Charles Moffat, Suzanne A. Eccles, Lindsay Stimson, Judata Wibawa, A. Donald, Florence I. Raynaud, Lindsay Bawden, Francesca Ann Day, Wynne Aherne, Elisabeth A. Bone, Anthea Hardcastle, Jo Owen, Andrew J. Belfield, Gary Box, Vanessa L. Clark, Sandra Van Meurs, Patel Sanjay Shashikant
Publikováno v:
Journal of medicinal chemistry. 53(24)
A novel series of HDAC inhibitors demonstrating class I subtype selectivity and good oral bioavailability is described. The compounds are potent enzyme inhibitors (IC50 values less than 100 nM), and improved activity in cell proliferation assays was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7365a837282ef1e8b699eedeedddf76f
https://pubmed.ncbi.nlm.nih.gov/21080647
https://pubmed.ncbi.nlm.nih.gov/21080647