EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS

Autor: Mark W Urban, Brittany A Charsar, Nicolette M Heinsinger, Shashirekha S Markandaiah, Lindsay Sprimont, Wei Zhou, Eric V Brown, Nathan T Henderson, Samantha J Thomas, Biswarup Ghosh, Rachel E Cain, Davide Trotti, Piera Pasinelli, Megan C Wright, Matthew B Dalva, Angelo C Lepore

Publikováno v: eLife, Vol 12 (2024)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss. Importantly, non-neuronal cell types such as astrocytes also play significant roles in disease pathogenesis. However, mechanisms of astrocyte contr

Externí odkaz: https://doaj.org/article/018e0a8bf2cb4c7db4d6c298aaf9f962

Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects

Autor: Lise Verbruggen, Lindsay Sprimont, Eduard Bentea, Pauline Janssen, Azzedine Gharib, Lauren Deneyer, Laura De Pauw, Olaya Lara, Hideyo Sato, Charles Nicaise, Ann Massie

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate antiporter system xc− in neurological disorders and in cancer, none of the proposed inhibitors is selective. In this context, a lot of research has been per

Externí odkaz: https://doaj.org/article/e5c8b01f7c4943ae966ece9e1e32fa8f

Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5β/B6 and ABCB5β/B9

Autor: Louise Gerard, Laurent Duvivier, Marie Fourrez, Paula Salazar, Lindsay Sprimont, Di Xia, Suresh V. Ambudkar, Michael M. Gottesman, Jean-Pierre Gillet

ABCB5 is a member of the ABC transporter superfamily composed of 48 transporters, which have been extensively studied for their role in cancer multidrug resistance and, more recently, in tumorigenesis. ABCB5 has been identified as a marker of skin pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f00b2e6e29de8a4cc0f5428ec092fab
https://doi.org/10.1101/2022.10.21.513191

Cystine-glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice

Autor: Ann Massie, Jacques Gilloteaux, Lindsay Sprimont, Kathleen De Swert, Pauline Janssen, Charles Nicaise, Mathias Van Bulck, Ilse Rooman

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Sprimont, L, Janssen, P, De Swert, K, Van Bulck, M, Roman, I, GILLOTEAUX, J, Massie, A & Nicaise, C 2021, ' Cystine–glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice ', Scientific Reports, vol. 11, no. 1, 12227 . https://doi.org/10.1038/s41598-021-91698-y

xCT is the specific subunit of System xc-, an antiporter importing cystine while releasing glutamate. Although xCT expression has been found in the spinal cord, its expression and role after spinal cord injury (SCI) remain unknown. The aim of this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c62c44b50c2a54103ce6e51d46bc68
https://pubmed.ncbi.nlm.nih.gov/34108554

xCT/Slc7a11 deletion accelerates motor recovery and improves histological outcomes following cervical spinal contusion in mice

Autor: Lindsay Sprimont, Ann Massie, Jacques Gilloteaux, Joanna Bouchat, Charles Nicaise

Publikováno v: Frontiers in Neuroscience. 12

xCT protein is the specific subunit of System xc-, a multi-proteic complex importing cystine into cell while releasing extracellular glutamate. Although xCT protein expression is detected in brain glial cells, its expression in the spinal cord and du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1b062fb2eb7007befae7913bfff16f