Combination peptide immunotherapy suppresses antibody and helper T-cell responses to the RhD protein in HLA-transgenic mice

Autor: Lindsay S. Hall, Andrew M. Hall, Wendy Pickford, Mark A. Vickers, Stanislaw J. Urbaniak, Robert N. Barker

Publikováno v: Haematologica, Vol 99, Iss 3 (2014)

The offspring from pregnancies of women who have developed anti-D blood group antibodies are at risk of hemolytic disease of the newborn. We have previously mapped four peptides containing immunodominant T-helper cell epitopes from the RhD protein an

Externí odkaz: https://doaj.org/article/d65adc0d76e443469cb6d2c8d5ba1b85

Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

Autor: Beverley Robertson, Adam Davie, Stuart M. Haslam, Huan Cao, Wendy J Pickford, Heather M. Wilson, Robert N. Barker, Heather J. Wassall, Gordon D. Brown, Sadie Henderson, Anne Dell, Aristotelis Antonopoulos, Megan A Forrester, J. Alexandra Rowe, Bhinal Patel, Gabriela Konieczny, Mark A. Vickers, Dimitris Tampakis, Michael Moss, Lindsay S Hall, Maria-Louise Williams, Beverley E. Minter, David C. Rees, John N. Brewin, Lars Erwig, Charlotte S. Lennon, Jenna Shepherd, Alanna Masson

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Cao, H, Antonopoulos, A, Henderson, S, Wassall, H, Brewin, J, Masson, A, Shepherd, J, Konieczny, G, Patel, B, Williams, M-L, Davie, A, Forrester, M A, Hall, L, Minter, B, Tampakis, D, Moss, M, Lennon, C, Pickford, W, Erwig, L, Robertson, B, Dell, A, Brown, G D, Wilson, H M, Rees, D C, Haslam, S M, Alexandra Rowe, J, Barker, R N & Vickers, M A 2021, ' Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance ', Nature Communications, vol. 12, no. 1, 1792 . https://doi.org/10.1038/s41467-021-21814

In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans (Man5-9GlcNAc2), expressed on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd89a3aee2973519b6303389fca5a20d
http://hdl.handle.net/10044/1/89825

Hemoglobin S induces exposure of red blood cell membrane skeleton microdomains bearing mannose that stimulate phagocytosis by macrophages: A molecular basis for hemolysis in sickle cell disease but protection against Plasmodium Falciparum malaria

Autor: Minter Beverly, Sadie Henderson, David C Rees, Anne Dell, Bhinal Patel, Aristotelis Antonopoulos, Dimitrios Tampakis, Stuart M. Haslam, Megan A Forrester, Alanna Masson, Mark A. Vickers, John Brewin, Jenna Shepherd, Heather J. Wassall, Robert N. Barker, Heather M. Wilson, Lindsay S Hall, Gabriela Konieczny, Huan Cao, Alexandra J Rowe

Publikováno v: 60th Annual Meeting of the American-Society-of-Hematology (ASH)

Heterozygosity for Hemoglobin (Hb) S, sickle cell trait (SCT), affects over 40 million people and confers resistance to severe infection by Plasmodium falciparum. Homozygosity for HbS, or compound heterozygosity with certain other alleles of Hb, affe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0110085ae1b4c0a992f13d0da980e84f
http://hdl.handle.net/10044/1/69059

The effect of aged erythrocytes and erythrocyte-derived microparticles on lymphomatous and healthy B cells

Autor: Robert N. Barker, Lindsay S Hall, Mark A. Vickers, Caitlin Hughes

Publikováno v: Journal of Inflammation (London, England)

Allogeneic blood transfusions have been associated with an increased risk of B cell Non-Hodgkin lymphoma (NHL), but the underlying mechanisms have not been identified. Stored erythrocytes undergo a number of age-related changes, including the release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b79cd116572cfe499e164da5d4637dd