Výsledky vyhledávání - "Lindsay R Wurst"

Akademický článek

Binding of soluble yeast β-glucan to human neutrophils and monocytes is complement- dependent

Autor: Nandita eBose, Anissa SH eChan, Faimola eGuerrero, Carolyn M Maristany, Richard M Walsh, Katie E Ertelt, Adria Bykowski Jonas, Keith B Gorden, Christine M Dudney, Lindsay R Wurst, Mike E Danielson, Natalie eElmasry, Andrew S Magee, Myra L Patchen, Xiaohong eQiu, John P Vasilakos

Publikováno v: Frontiers in Immunology, Vol 4 (2013)

The immunomodulatory properties of yeast β-1,3/1,6 glucans are mediated through their ability to be recognized by human innate immune cells. While several studies have investigated binding of opsonized and unopsonized particulate β-glucans to human

Externí odkaz: https://doaj.org/article/b7ce282968f54f0b9afc6646f7803a14

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Modification of the degree of branching of a beta-(1,3)-glucan affects aggregation behavior and activity in an oxidative burst assay

Autor: Will Paul M, Ryan R. Langeslay, Michael E. Danielson, Lindsay R. Wurst, Vanessa A. Iiams, Andrew S. Magee

Publikováno v: Biopolymers. 103:665-674

Scleroglucan is a β-(1,3)-glucan which is highly branched at the 6-position with a single glucose residue. Acid hydrolysis of a high molecular weight scleroglucan gave a medium molecular weight, freely soluble material. Linkage analysis by the parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9acb0130cfadc2ec9d87caa03fef89f
https://doi.org/10.1002/bip.22685

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Modification of the degree of branching of a beta-(1,3)-glucan affects aggregation behavior and activity in an oxidative burst assay

Autor: Andrew S, Magee, Ryan R, Langeslay, Paul M, Will, Michael E, Danielson, Lindsay R, Wurst, Vanessa A, Iiams

Publikováno v: Biopolymers. 103(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::613eb1ea7f0b4c31b61f494313a80d16
https://pubmed.ncbi.nlm.nih.gov/26015027

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Abstract A160: Imprime PGG binds to neutrophils through complement, Fc, and dectin-1 receptors, priming these cells for enhanced ROS production and tumor cell cytotoxicity

Autor: Adria Jonas, Keith B. Gorden, Steven M. Leonardo, Anissa S.H. Chan, Xiaohong Qui, Jeremy R. Graff, Lindsay R. Wurst, Ross B. Fulton

Publikováno v: Cancer Immunology Research. 4:A160-A160

Imprime PGG (Imprime), a soluble yeast 1,3/1,6 β-glucan, is being developed as a novel cancer immunotherapy in conjunction with anti-tumor antibodies in several cancers. In clinical studies, including randomized Phase 2 clinical trials in the 1st-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dccfdfc8a1f5f60ea45609971820636c
https://doi.org/10.1158/2326-6074.cricimteatiaacr15-a160

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Differential regulation of oxidative burst by distinct β-glucan-binding receptors and signaling pathways in human peripheral blood mononuclear cells

Autor: Michael E. Danielson, Will Paul M, Nandita Bose, John P. Vasilakos, Anissa S.H. Chan, Sonja E Nodland, Jurandir J. Dalle Lucca, Frank J. Lebeda, Megan L LeRoux, Myra L. Patchen, Lindsay R. Wurst, Christine M. Dudney

Publikováno v: Glycobiology. 24(4)

β-Glucans possess broad immunomodulatory properties, including activation of innate immune functions such as oxidative burst activity. The differential roles of complement receptor type 3 (CR3) and Dectin-1, the known β-glucan receptors, and their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e1c9d9bbdd6241be48504a761eeff6
https://pubmed.ncbi.nlm.nih.gov/24440830

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Binding of soluble yeast β-glucan to human neutrophils and monocytes is complement- dependent

Autor: Faimola Guerrero, Michael E. Danielson, Natalie Elmasry, Keith B. Gorden, John P. Vasilakos, Andrew S. Magee, Xiaohong Qiu, Anissa S.H. Chan, Myra L. Patchen, Carolyn M. Maristany, Richard Walsh, Kathleen E. Ertelt, Christine M. Dudney, Lindsay R. Wurst, Adria Jonas, Nandita Bose

Publikováno v: Frontiers in Immunology, Vol 4 (2013)
Frontiers in Immunology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4feb377b175c4ace838233aecd7d2be1
http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00230/full

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Abstract A014: Endogenous anti-β-glucan antibodies and FcgRIIA (CD32a) single nucleotide polymorphisms (SNP) as potential predictive biomarkers for the efficacy of Imprime PGG immunotherapy in cancer patients

Autor: Nadine Ottoson, Steven M. Leonardo, Keith B. Gorden, Adria Jonas, Peter Maimonis, Katie Ertelt, Ben Harrison, Anissa S.H. Chan, Nandita Bose, Xiaohong Qiu, Lindsay R. Wurst

Publikováno v: Cancer Immunology Research. 4:A014-A014

Imprime PGG (Imprime), a soluble yeast 1,3/1,6 β-glucan, is being developed as a novel cancer immunotherapy in conjunction with anti-tumor antibodies in several cancers. Randomized Phase 2 clinical trials of Imprime in the 1st-line treatment of stag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d7e496df1dfc00e893b20c229fa7038
https://doi.org/10.1158/2326-6074.cricimteatiaacr15-a014

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Abstract A08: Distribution, cutoff, and functional significance of a potential biomarker for Imprime PGG, an experimental cancer immunotherapeutic, in a healthy subject population

Autor: Nadine Ottoson, Adria Jonas, Xiaohong Qiu, Richard Walsh, Nandita Bose, Diane McMurray, Lindsay R. Wurst, Steven M. Leonardo, Ben Harrison, Peter Maimonis, Katie Ertelt

Publikováno v: Cancer Immunology Research. 3:A08-A08

Imprime PGG (Imprime) is a yeast-derived beta-1,3/1,6 glucan that binds complement receptor 3 (CR3) on innate immune cells and enables these cells to exert anti-tumor activity against tumor cells that have been opsonized by iC3b following targeting b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b87b5d2fa78d8e54e71327993d24ac5a
https://doi.org/10.1158/2326-6074.tumimm14-a08

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Abstract 5034: Imprime PGG decreases regulatory T cell suppression and enhances T cell proliferation and differentiation revealing additional mechanisms for its anti-tumor activity

Autor: Ross B. Fulton, Steven M. Leonardo, Keith B. Gorden, Lindsay R. Wurst

Publikováno v: Cancer Research. 75:5034-5034

Imprime PGG is a soluble yeast-derived β-glucan immunomodulator being developed for treatment of cancer in combination with anti-tumor antibodies (Abs). Imprime PGG binds to complement receptor (CR)3 on innate immune cells (neutrophils and monocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2f39baea7d8116454e09dd0ff449873
https://doi.org/10.1158/1538-7445.am2015-5034

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