Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lindsay Perusek"'
Publikováno v:
Stem Cell Research, Vol 27, Iss , Pp 95-104 (2018)
Accumulation of lipofuscin in the retinal pigmented epithelium (RPE) is observed in retinal degenerative diseases including Stargardt disease and age-related macular degeneration. Bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E) is a major co
Externí odkaz:
https://doaj.org/article/fb520ff66a75468e9d74fa07c175268f
Autor:
Tadao Maeda, Lindsay Perusek
Publikováno v:
Nutrients, Vol 5, Iss 7, Pp 2646-2666 (2013)
The visual cycle is a sequential enzymatic reaction for vitamin A, all-trans-retinol, occurring in the outer layer of the human retina and is essential for the maintenance of vision. The central source of retinol is derived from dietary intake of bot
Externí odkaz:
https://doaj.org/article/e16ef1b596b049ae8d5da6baa3151bab
Autor:
Akiko Maeda, Lindsay Perusek, Zhiqian Dong, Marcin Golczak, Grazyna Palczewska, Brian M. Kevany, Eisuke Arai, Krzysztof Palczewski
Publikováno v:
Journal of Biological Chemistry. 291:26937-26949
Accumulation of bis-retinoids in the retinal pigmented epithelium (RPE) is a hallmark of aging and retinal disorders such as Stargardt disease and age-related macular degeneration. These aberrant fluorescent condensation products, including di-retino
Autor:
Vipul M. Parmar, Masayo Takahashi, John W. Crabb, Tanu Parmar, Akiko Maeda, Lindsay Perusek, Anouk Georges
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(9)
It has become increasingly important to understand how retinal inflammation is regulated because inflammation plays a role in retinal degenerative diseases. Lipocalin 2 (LCN2), an acute stress response protein with multiple innate immune functions, i
Autor:
Osamu Sawada, Tadao Maeda, Akiko Maeda, Hideo Kohno, Scott Howell, Shigemi Matsuyama, Lindsay Perusek
Publikováno v:
Experimental Eye Research. 123:27-36
The current study investigates the cellular events which trigger activation of proapoptotic Bcl-2-associated × protein (Bax) in retinal cell death induced by all-trans-retinal (atRAL). Cellular events which activate Bax, such as DNA damage by oxidat
Publikováno v:
Neuroscience research. 123
Retinal tissues generated from human pluripotent stem cells can be an excellent tool for investigating pathogenesis of retinal diseases and developing new pharmacologic therapies. Moreover, patient derived retinal tissues could allow for retinal tran
Autor:
Krzysztof Palczewski, Tadao Maeda, Lindsay Perusek, Jaume Amengual, Johannes von Lintig, Darwin Babino
Publikováno v:
Molecular Pharmacology. 80:943-952
Synthetic 9-cis-stereoisomers of vitamin A (all-trans-retinol) are especially promising agents for the fight against blinding diseases. Several studies suggested that 9-cis-β,β-carotene (9-cis-BC), a natural and abundant β-carotene isomer in the d
Autor:
Hiroshi Maeno, Yun-Zheng Le, Bhubanananda Sahu, Tanu Parmar, Yu Chen, Akiko Maeda, Eisuke Arai, Lindsay Perusek, Krzysztof Palczewski, Carlos S. Subauste
Publikováno v:
The Journal of biological chemistry. 290(48)
Autophagy is an evolutionarily conserved catabolic mechanism that relieves cellular stress by removing/recycling damaged organelles and debris through the action of lysosomes. Compromised autophagy has been implicated in many neurodegenerative diseas
Autor:
Wenyu Sun, Yun-Zheng Le, Lindsay Perusek, Krzysztof Palczewski, Vipulkumar M. Parmar, Michael D. Griswold, Akiko Maeda, Bhubanananda Sahu
Publikováno v:
The Journal of biological chemistry. 290(45)
Regeneration of the visual chromophore, 11-cis-retinal, is a crucial step in the visual cycle required to sustain vision. This cycle consists of sequential biochemical reactions that occur in photoreceptor cells and the retinal pigmented epithelium (
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1271
The perception of light begins when photons reach retinal tissue located at the back of the eye and photoisomerize the visual chromophore 11-cis-retinal to all-trans-retinal within photoreceptor cells. Isomerization of 11-cis-retinal activates the pr