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Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.

Autor: Degorce SL; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom. Electronic address: sebastien.degorce@astrazeneca.com., Anjum R; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States., Dillman KS; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States., Drew L; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States., Groombridge SD; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Halsall CT; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Lenz EM; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom., Lindsay NA; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom., Mayo MF; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States., Pink JH; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Robb GR; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom., Scott JS; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom., Stokes S; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom., Xue Y; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg SE-431 83, Mölndal, Sweden.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 Feb 15; Vol. 26 (4), pp. 913-924. Date of Electronic Publication: 2018 Jan 17.

A small molecule mitigates hearing loss in a mouse model of Usher syndrome III.

Autor: Alagramam KN; Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.; Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.; Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA., Gopal SR; Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA., Geng R; Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA., Chen DH; Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA., Nemet I; Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, USA., Lee R; Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, USA., Tian G; Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, USA., Miyagi M; Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA., Malagu KF; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Lock CJ; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Esmieu WR; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Owens AP; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Lindsay NA; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Ouwehand K; Charles River Nederland BV, Leiden, the Netherlands., Albertus F; Charles River Nederland BV, Leiden, the Netherlands., Fischer DF; Charles River Nederland BV, Leiden, the Netherlands., Bürli RW; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., MacLeod AM; BioFocus, a Charles River company, Chesterford Research Park, Saffron Walden, UK., Harte WE; Office of Translation and Innovation, Case Western Reserve University, Cleveland, Ohio, USA., Palczewski K; Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, USA., Imanishi Y; Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, USA.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2016 Jun; Vol. 12 (6), pp. 444-51. Date of Electronic Publication: 2016 Apr 25.

Usher syndrome IIIA: a review of the disorder and preclinical research advances in therapeutic approaches.

Autor: Marouf, Azmi, Johnson, Benjamin, Alagramam, Kumar N.

Publikováno v: Human Genetics; Apr2022, Vol. 141 Issue 3/4, p759-783, 25p

EMERGING APPROACHES FOR RESTORATION OF HEARING AND VISION.

Autor: Kleinlogel, Sonja, Vogl, Christian, Jeschke, Marcus, Neef, Jakob, Moser, Tobias

Publikováno v: Physiological Reviews; Oct2020, Vol. 100 Issue 4, p1467-1525, 59p, 20 Color Photographs, 3 Charts