Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Lindsay N. Hayes"'
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Prenatal immune stress induces a prolonged blunting of microglia activation that impacts striatal connectivity
Autor: Lindsay N. Hayes, Kyongman An, Elisa Carloni, Fangze Li, Elizabeth Vincent, Manish Paranjpe, Gül Dölen, Loyal A. Goff, Adriana Ramos, Shin-ichi Kano, Akira Sawa
Recent studies suggested that microglia, the primary brain immune cells, can affect circuit connectivity and neuronal function1–3. Microglia infiltrate the neuroepithelium early in embryonic development and are maintained in the brain throughout ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9973dfeaacd28dd1b64e5e9a94bdebd
https://doi.org/10.1101/2021.12.27.473694
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3
Developmental Stressors Induce Innate Immune Memory in Microglia and Contribute to Disease Risk
Autor: Lindsay N. Hayes, Elisa Carloni, Adriana Ramos
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 13035, p 13035 (2021)
International Journal of Molecular Sciences
Many types of stressors have an impact on brain development, function, and disease susceptibility including immune stressors, psychosocial stressors, and exposure to drugs of abuse. We propose that these diverse developmental stressors may utilize a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3d9f9f16bacc94c634f0fb5bf423b2
https://www.mdpi.com/1422-0067/22/23/13035
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4
Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation
Autor: Juliet Richetto, Flavia Mueller, Urs Meyer, Ulrike Weber-Stadlbauer, Daniela D. Pollak, Alice Zambon, Lindsay N. Hayes, Akira Sawa
Maternal immune activation (MIA) models that are based on administration of the viral mimetic, poly(I:C), are widely used as experimental tools to study neuronal and behavioral dysfunctions in relation to immune-mediated neurodevelopmental disorders
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09a76c8b8524b5eece47f43d709c7eb
https://doi.org/10.5167/uzh-180195
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6
Neuregulin 3 Knockout Mice Exhibit Behaviors Consistent with Psychotic Disorders
Autor: Pei-Lung Chen, Mikhail V. Pletnikov, Lindsay N. Hayes, Cassandra Obie, Ann E. Pulver, David Valle, A. V. Shevelkin, Gary Steel, Mariela Zeledon, Dimitrios Avramopoulos, Akira Sawa
Publikováno v: Complex Psychiatry. 2:79-87
Neuregulin 3 (NRG3) is a paralog of NRG1. Genetic studies in schizophrenia demonstrate that risk variants in NRG3 are associated with cognitive and psychotic symptom severity, and several intronic single nucleotide polymorphisms in NRG3 are associate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e2d1b2f65b5ce8ff4d9619c7875ff2
https://doi.org/10.1159/000445836
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7
Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances
Autor: Shin Ichi Kano, Atsushi Kamiya, Minae Niwa, Atsushi Saito, Mari Kondo, Catherine A. Foss, Jennifer M. Coughlin, Daisuke Fukudome, Martin G. Pomper, Travis E. Faust, Brian J. Lee, Akira Sawa, Lindsay N. Hayes
Publikováno v: Schizophrenia research. 197
Changes in inflammatory cascades have been implicated in the underlying pathophysiology of psychosis. Translocator protein 18 kDa (TSPO) has been used to assess neuroinflammatory processes in psychotic disorders. Nonetheless, it is unclear whether TS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064689f7b91986ce861ec3cec02cd84e
https://pubmed.ncbi.nlm.nih.gov/29398205
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8
Duration of Shh signaling contributes to mDA neuron diversity
Autor: Sohyun Ahn, Hui Wang, Sherry Ralls, Lindsay N. Hayes
Publikováno v: Developmental Biology. 374:115-126
Sonic hedgehog (Shh) signaling is critical for various developmental processes including specification of the midbrain dopamine (mDA) neurons in the ventral mesencephalon (vMes). While the timing of Shh and its response gene Gli1 segregates mDA neuro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edeb1697be0138693688bfca9cf4f573
https://doi.org/10.1016/j.ydbio.2012.11.016
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9
Infection and inflammation in schizophrenia and bipolar disorder
Autor: Robert H. Yolken, Katrina Rodriguez, Emily G. Severance, William W. Eaton, Lindsay N. Hayes, Shuojia Yang, Akira Sawa, Teppei Tanaka, Taro Matsuda
Publikováno v: Neuroscience research. 115
The present study investigated the relationship between exposure to infectious agents and inflammation markers in individuals with schizophrenia (SZ), bipolar disorder (BP), and controls without a psychiatric disorder. We measured plasma levels of an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0743bc0b9f3a274d0bca01a78c85df31
https://pubmed.ncbi.nlm.nih.gov/27856235
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10
Reduction of plasma glutathione in psychosis associated with schizophrenia and bipolar disorder in translational psychiatry
Autor: Thomas W. Sedlak, F. C. Nucifora, Brian J. Lee, Leslie G. Nucifora, William W. Eaton, T Matsuda, Ramin Mojtabai, M Kim, Akira Sawa, Lindsay N. Hayes, Teppei Tanaka
Publikováno v: Translational Psychiatry
The establishment of mechanism-driven peripheral markers is important for translational psychiatry. Many groups, including ours, have addressed molecular alterations in peripheral tissues in association with symptomatic changes in major illnesses. Ox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4577616db9dccda92051d6f3bb1d9b1
http://europepmc.org/articles/PMC5611744
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