Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Lindsay Meyerdirk"'
Autor:
Thomas M. Goralski, Lindsay Meyerdirk, Libby Breton, Laura Brasseur, Kevin Kurgat, Daniella DeWeerd, Lisa Turner, Katelyn Becker, Marie Adams, Daniel J. Newhouse, Michael X. Henderson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract A key hallmark of Parkinson’s disease (PD) is Lewy pathology. Composed of α-synuclein, Lewy pathology is found both in dopaminergic neurons that modulate motor function, and cortical regions that control cognitive function. Recent work ha
Externí odkaz:
https://doaj.org/article/adda231edd6d4dd9bf1d27ea3cc41c46
Autor:
Lucas Stetzik, Gabriela Mercado, Jennifer A. Steiner, Allison Lindquist, Carla Gilliland, Emily Schulz, Lindsay Meyerdirk, Lindsey Smith, Jeremy Molina, Darren J. Moore
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106647- (2024)
In this study, we develop and validate a new Parkinson's disease (PD) mouse model that can be used to better understand how the disease progresses and to test the effects of new, potentially disease-modifying, PD therapies. Our central hypothesis is
Externí odkaz:
https://doaj.org/article/ae459f2fac20428ba33359c16d5d5001
Autor:
Hongqiao Zhang, Carla D'Agostino, Christopher Tulisiak, Max A. Thorwald, Liza Bergkvist, Allison Lindquist, Lindsay Meyerdirk, Emily Schulz, Katelyn Becker, Jennifer A. Steiner, Mafalda Cacciottolo, Mohit Kwatra, Nolwen L. Rey, Martha L. Escobar Galvis, Jiyan Ma, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch, Patrik Brundin
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e15622- (2023)
Background: Epidemiological studies have variably linked air pollution to increased risk of Parkinson’s disease (PD). However, there is little experimental evidence for this association. Alpha-synuclein (α-syn) propagation plays central roles in P
Externí odkaz:
https://doaj.org/article/2cb7b45f11bf473183868a0bdea5ceb7
Autor:
Lucas Stetzik, Gabriela Mercado, Lindsey Smith, Sonia George, Emmanuel Quansah, Katarzyna Luda, Emily Schulz, Lindsay Meyerdirk, Allison Lindquist, Alexis Bergsma, Russell G. Jones, Lena Brundin, Michael X. Henderson, John Andrew Pospisilik, Patrik Brundin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
There is growing evidence for the key role of microglial functional state in brain pathophysiology. Consequently, there is a need for efficient automated methods to measure the morphological changes distinctive of microglia functional states in resea
Externí odkaz:
https://doaj.org/article/1bddc0e28bb347448bdadb55a853f2cb
Autor:
Liqiang Chen, Chetan Nagaraja, Samuel Daniels, Zoe A Fisk, Rachel Dvorak, Lindsay Meyerdirk, Jennifer A Steiner, Martha L Escobar Galvis, Michael X Henderson, Maxime WC Rousseaux, Patrik Brundin, Hong-Yuan Chu
Publikováno v:
eLife, Vol 11 (2022)
The presynaptic protein α-synuclein (αSyn) has been suggested to be involved in the pathogenesis of Parkinson’s disease (PD). In PD, the amygdala is prone to develop insoluble αSyn aggregates, and it has been suggested that circuit dysfunction i
Externí odkaz:
https://doaj.org/article/6fe1aff23dfb40c5a9bc34b19b775ed3
Autor:
Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Alpha-synuclein inclusions, the hallmarks of synucleinopathies, are suggested to spread along neuronal connections in a stereotypical pattern in the brains of patients. Ample evidence now supports that pathological forms of alpha-synuclein p
Externí odkaz:
https://doaj.org/article/392d3687fdd945a8b98109737c3aa20d
Autor:
Michaela E. Johnson, Liza Bergkvist, Lucas Stetzik, Jennifer A. Steiner, Lindsay Meyerdirk, Emily Schulz, Emily Wolfrum, Kelvin C. Luk, Daniel W. Wesson, Dimitri Krainc, Patrik Brundin
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105513- (2021)
Autophagic dysregulation and lysosomal impairment have been implicated in the pathogenesis of Parkinson's disease, partly due to the identification of mutations in multiple genes involved in these pathways such as GBA, SNCA, ATP13a2 (also known as PA
Externí odkaz:
https://doaj.org/article/623a98fa3aef46ea809f14eccbe44977
Autor:
Sonia George, Nolwen L. Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, Emily Schulz, Steven Pierce, Amanda R. Burmeister, Zachary Madaj, Jennifer A. Steiner, Martha L. Escobar Galvis, Lena Brundin, Patrik Brundin
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-22 (2019)
Abstract Background Cell-to-cell propagation of α-synuclein (α-syn) aggregates is thought to contribute to the pathogenesis of Parkinson’s disease (PD) and underlie the spread of α-syn neuropathology. Increased pro-inflammatory cytokine levels a
Externí odkaz:
https://doaj.org/article/1a101c46905448c39fa868188fc16e41
Autor:
Wouter Peelaerts, Liza Bergkvist, Sonia George, Michaela Johnson, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Zachary Madaj, Jiyan Ma, Katelyn Becker, K. Peter R. Nilsson, Jerry R. Colca, Patrik Brundin
Publikováno v:
Free Neuropathology, Vol 1, Pp 33-33 (2020)
Epidemiological studies suggest a link between type-2 diabetes and Parkinson’s disease (PD) risk. Treatment of type-2 diabetes with insulin sensitizing drugs lowers the risk of PD. We previously showed that the insulin sensitizing drug, MSDC-0160,
Externí odkaz:
https://doaj.org/article/1a77645d12c548a3ba5d9c06a4db6d52
Autor:
Wouter Peelaerts, Gabriela Mercado, Sonia George, Marie Villumsen, Alysa Kasen, Miguel Aguileta, Christian Linstow, Alexandra B. Sutter, Emily Kuhn, Lucas Stetzik, Rachel Sheridan, Liza Bergkvist, Lindsay Meyerdirk, Allison Lindqvist, Martha L. Escobar Gavis, Chris Van den Haute, Scott J. Hultgren, Veerle Baekelandt, J. Andrew Pospisilik, Tomasz Brudek, Susana Aznar, Jennifer A. Steiner, Michael X. Henderson, Lena Brundin, Magdalena I. Ivanova, Tom J. Hannan, Patrik Brundin
Publikováno v:
Acta Neuropathologica. 145:541-559
Symptoms in the urogenital organs are common in multiple system atrophy (MSA), also in the years preceding the MSA diagnosis. It is unknown how MSA is triggered and these observations in prodromal MSA led us to hypothesize that synucleinopathy could