Výsledky vyhledávání - "Lindsay Maidt"

Increased oxidative stress brought on by pro-inflammatory cytokines in neurodegenerative processes and the protective role of nitrone-based free radical traps

Autor: R.A. Floyd, Kent A. Robinson, Quentin N. Pye, Lindsay Maidt, F. Jaffery, Kenneth Hensley, Charles A. Stewart

Publikováno v: Life Sciences. 65:1893-1899

Nitrone-based free radical traps (NFTs) have been shown to be protective in several neurodegenerative models. Our research has strongly implicated that: A) several neurodegenerative conditions exhibit increased levels of pro-inflammatory cytokines wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2279f2c1442b2e12a9270b7414d37cec
https://doi.org/10.1016/s0024-3205(99)00443-9

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8-Hydroxydeoxyguanosine in DNA from TPA-Stimulated Human Granulocytes

Autor: Lindsay Maidt, Robert A. Floyd, H. C. Birnboim, Tina Raynor

Publikováno v: Free Radical Research. 20:113-117

8-Hydroxydeoxyguanosine (8-OHdG) is now widely used as a sensitive marker of oxidative damage to DNA. When human granulocytes are stimulated with TPA, they release a large quantity of reactive oxygen species (superoxide, hydrogen peroxide) which migh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0dd669d039b056d505a034a0c421c3
https://doi.org/10.3109/10715769409147508

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The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation

Autor: Tapas K. Hazra, Robert A. Floyd, Sankar Mitra, Lindsay Maidt, Tadahide Izumi

8-Oxoguanine (8-oxoG), induced by reactive oxygen species (ROS) and ionizing radiation, is arguably the most important mutagenic lesion in DNA. This oxidized base, because of its mispairing with A, induces GC-->TA transversion mutations often observe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48594c34e34d56a2018ac427b9b54f63
https://europepmc.org/articles/PMC147966/

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ADP-iron as a Fenton reactant: radical reactions detected by spin trapping, hydrogen abstraction, and aromatic hydroxylation

Autor: John M.C. Gutteridge, Lindsay Maidt, Robert A. Floyd, Imre Zs.-Nagy

Publikováno v: Archives of biochemistry and biophysics. 277(2)

A mixture of ADP, ferrous ions, and hydrogen peroxide (H2O2) generates hydroxyl radicals (OH) that attack the spin trap DMPO (5,5-dimethyl-pyrollidine-N-oxide) to yield the hydroxyl free radical spin-adduct, degrade deoxyribose and benzoate with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acaee9b3bfaea09ceec65a7850b9456
https://pubmed.ncbi.nlm.nih.gov/2155582

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Methylene blue plus light mediates 8-hydroxy 2'-deoxyguanosine formation in DNA preferentially over strand breakage

Autor: John M.C. Gutteridge, J.E. Schneider, S. Price, Robert A. Floyd, Lindsay Maidt

Publikováno v: Nucleic acids research. 18(3)

Methylene blue (MB) plus light, in the presence of oxygen, mediates formation of 8-hydroxyguanine in DNA. The yield of 8-hydroxyguanine may be as much as from 2 to 4% of the guanines present. The results presented here show that treatment of supercoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7831fbc94fbdf26b87c7192b4f7ccfb
https://pubmed.ncbi.nlm.nih.gov/2155406

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