Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lindsay M. Repka"'
Publikováno v:
ACS Med Chem Lett
[Image: see text] γ-Aminobutyric acid type A (GABA(A)) receptors are key mediators of central inhibitory neurotransmission and have been implicated in several disorders of the central nervous system. Some positive allosteric modulators (PAMs) of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1626c8c239e87aba046a2597ce5e4a8
https://resolver.caltech.edu/CaltechAUTHORS:20200924-152452617
https://resolver.caltech.edu/CaltechAUTHORS:20200924-152452617
Publikováno v:
Journal of the American Chemical Society. 140:4200-4203
The dehydratase NisB performs stepwise tRNA(Glu)-dependent glutamylation of Ser/Thr residues and subsequent glutamate elimination to effect eight dehydrations in the biosynthesis of the antibacterial peptide nisin. Its substrate, NisA, bears a C-term
Publikováno v:
Chemical Reviews
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic. Lanthipeptides that display antimicrobial activity are called lan
Sublancin is a 37-amino acid antimicrobial peptide belonging to the glycocin family of natural products. It contains two helices that are held together by two disulfide bonds, as well as an unusual S-glucosidic linkage to a Cys in a loop connecting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f764f00e61657c861dcf2dd766db7356
https://europepmc.org/articles/PMC5732038/
https://europepmc.org/articles/PMC5732038/
Autor:
Shi-Hui Dong, Wilfred A. van der Donk, Lindsay M. Repka, Weixin Tang, Chang He, Satish K. Nair
Publikováno v:
Chemical Science
The class II lanthipeptide protease LicP maturates through self-cleavage and enables sequence-specific, traceless peptide bond cleavage.
The final step of lanthipeptide biosynthesis involves the removal of leader peptides by dedicated proteases.
The final step of lanthipeptide biosynthesis involves the removal of leader peptides by dedicated proteases.
Publikováno v:
Journal of the American Chemical Society. 134:5131-5137
The tandem Friedel-Crafts conjugate addition/asymmetric protonation reaction between 2-substituted indoles and methyl 2-acetamidoacrylate is reported. The reaction is catalyzed by (R)-3,3'-dibromo-BINOL in the presence of stoichiometric SnCl(4), and
Autor:
Sarah E. Bernard, Shenjuti Chowdhury, Nadia C. Abascal, Elsy Santizo-Deleon, Christian M. Rojas, Abigail L. Smenton, Ritu Gupta, Lindsay M. Repka, Victoria Baranov, Brisa Hurlocker
Publikováno v:
The Journal of Organic Chemistry. 76:2240-2244
By using (N-tosyloxy)-3-O-carbamoyl-D-glucal 10, which removes the need for a hypervalent iodine(III) oxidant, we provide evidence for rhodium nitrenoid-mediated ipso C-H activation as the origin of a C3-oxidized dihydropyranone product 3. This syste
Autor:
Lindsay M. Repka, Sarah E. Reisman
Publikováno v:
ChemInform. 45
Pyrroloindoline alkaloids constitute a large family of natural products that has inspired the development of an impressive array of new reactions to prepare the key heterocyclic motif. This synopsis will address catalytic, asymmetric reactions develo
Publikováno v:
Journal of the American Chemical Society. 132:14418-14420
(R)-BINOL·SnCl(4) was found to catalyze a formal [3 + 2] cycloaddition reaction between C(3)-substituted indoles and 2-amidoacrylates to provide pyrroloindolines. A variety of pyrroloindolines were prepared with high enantioselectivity in one step f
Autor:
Lindsay M. Repka, Sarah E. Reisman
Publikováno v:
The Journal of organic chemistry. 78(24)
Pyrroloindoline alkaloids constitute a large family of natural products that has inspired the development of an impressive array of new reactions to prepare the key heterocyclic motif. This synopsis will address catalytic, asymmetric reactions develo