Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Lindsay M. Herbert"'
1
Akademický článek
Smooth muscle Acid-sensing ion channel 1a as a therapeutic target to reverse hypoxic pulmonary hypertension
Autor: Selina M. Garcia, Tracy R. Yellowhair, Neil D. Detweiler, Rosstin Ahmadian, Lindsay M. Herbert, Laura V. Gonzalez Bosc, Thomas C. Resta, Nikki L. Jernigan
Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)
Acid-sensing ion channel 1a (ASIC1a) is a voltage-independent, non-selective cation channel that conducts both Na+ and Ca2+. Activation of ASIC1a elicits plasma membrane depolarization and stimulates intracellular Ca2+-dependent signaling pathways in
Externí odkaz: https://doaj.org/article/5b0acd1eae6c415191754f383d469cd3
Zobrazit plný text záznamu
2
Akademický článek
Coupling of store-operated calcium entry to vasoconstriction is acid-sensing ion channel 1a dependent in pulmonary but not mesenteric arteries.
Autor: Selina M Garcia, Lindsay M Herbert, Benjimen R Walker, Thomas C Resta, Nikki L Jernigan
Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0236288 (2020)
Although voltage-gated Ca2+ channels (VGCC) are a major Ca2+ entry pathway in vascular smooth muscle cells (VSMCs), several other Ca2+-influx mechanisms exist and play important roles in vasoreactivity. One of these is store-operated Ca2+ entry (SOCE
Externí odkaz: https://doaj.org/article/afaad2b83bb94e99977fb4948228cc75
Zobrazit plný text záznamu
3
Akademický článek
Contribution of reactive oxygen species to the pathogenesis of pulmonary arterial hypertension.
Autor: Nikki L Jernigan, Jay S Naik, Laura Weise-Cross, Neil D Detweiler, Lindsay M Herbert, Tracylyn R Yellowhair, Thomas C Resta
Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0180455 (2017)
Pulmonary arterial hypertension is associated with a decreased antioxidant capacity. However, neither the contribution of reactive oxygen species to pulmonary vasoconstrictor sensitivity, nor the therapeutic efficacy of antioxidant strategies in this
Externí odkaz: https://doaj.org/article/1a2e75e75e8248a18fdc9866cb7f85e6
Zobrazit plný text záznamu
6
Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCβ/Mitochondrial Oxidant Signaling
Autor: Benjimen R. Walker, Nancy L. Kanagy, Lindsay M. Herbert, Simin Yan, Michelle A. Sands, Charles E. Norton, Joshua R. Sheak, Laura V. Gonzalez Bosc, Thomas C. Resta, Jessica B. Snow, Nikki L. Jernigan, Laura Weise-Cross
Publikováno v: Am J Respir Cell Mol Biol
Pulmonary vasoconstriction resulting from intermittent hypoxia (IH) contributes to pulmonary hypertension (pHTN) in patients with sleep apnea (SA), although the mechanisms involved remain poorly understood. Based on prior studies in patients with SA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee5f0816d2f92fbb287cdd42ec07e72
https://doi.org/10.1165/rcmb.2019-0351oc
Zobrazit plný text záznamu
7
Loss of acid-sensing ion channel 2 enhances pulmonary vascular resistance and hypoxic pulmonary hypertension
Autor: Kenneth G. Vigil, Simin Yan, Benjimen R. Walker, Joshua R. Sheak, Lindsay M. Herbert, Neil D. Detweiler, Nikki L. Jernigan, Selina Garcia, Thomas C. Resta
Publikováno v: J Appl Physiol (1985)
Acid-sensing ion channels (ASICs) are voltage-insensitive cation channels that contribute to cellular excitability. We previously reported that ASIC1 in pulmonary artery smooth muscle cells (PASMC) contribute to pulmonary vasoreactivity and vascular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5879591e80dc86a10a1df5f1f77a6d2
https://doi.org/10.1152/japplphysiol.00894.2018
Zobrazit plný text záznamu
8
Coupling of store-operated calcium entry to vasoconstriction is acid-sensing ion channel 1a dependent in pulmonary but not mesenteric arteries
Autor: Lindsay M. Herbert, Nikki L. Jernigan, Benjimen R. Walker, Thomas C. Resta, Selina Garcia
Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0236288 (2020)
PLoS ONE
Although voltage-gated Ca2+ channels (VGCC) are a major Ca2+ entry pathway in vascular smooth muscle cells (VSMCs), several other Ca2+-influx mechanisms exist and play important roles in vasoreactivity. One of these is store-operated Ca2+ entry (SOCE
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4b6bee78c13066bd3cf4c82b272453
https://doaj.org/article/afaad2b83bb94e99977fb4948228cc75
Zobrazit plný text záznamu
9
RhoA increases ASIC1a plasma membrane localization and calcium influx in pulmonary arterial smooth muscle cells following chronic hypoxia
Autor: Nikki L. Jernigan, Lindsay M. Herbert, Thomas C. Resta
Publikováno v: American Journal of Physiology-Cell Physiology. 314:C166-C176
Increases in pulmonary arterial smooth muscle cell (PASMC) intracellular Ca2+ levels and enhanced RhoA/Rho kinase-dependent Ca2+ sensitization are key determinants of PASMC contraction, migration, and proliferation accompanying the development of hyp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1a603e11ddde3f77f36d14e7afcc44
https://doi.org/10.1152/ajpcell.00159.2017
Zobrazit plný text záznamu
10
The role of the lectin-like oxLDL receptor (LOX-1) in traffic-generated air pollution exposure-mediated alteration of the brain microvasculature in Apolipoprotein (Apo) E knockout mice
Autor: Jacob D. McDonald, Usa Suwannasual, Lindsay M. Herbert, JoAnn Lucero, Amie K. Lund
Publikováno v: Inhalation Toxicology. 29:266-281
Recent studies have shown a strong correlation between air pollution-exposure and detrimental outcomes in the central nervous system, including alterations in blood brain barrier (BBB) integrity, neuroinflammation, and neurodegeneration. However, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa3adf8d44076d337ccf0249b723a26
https://doi.org/10.1080/08958378.2017.1357774
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje