Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lindsay M Webb"'
Autor:
Kyle A Jablonski, Stephanie A Amici, Lindsay M Webb, Juan de Dios Ruiz-Rosado, Phillip G Popovich, Santiago Partida-Sanchez, Mireia Guerau-de-Arellano
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145342 (2015)
Classically (M1) and alternatively activated (M2) macrophages exhibit distinct phenotypes and functions. It has been difficult to dissect macrophage phenotypes in vivo, where a spectrum of macrophage phenotypes exists, and also in vitro, where low or
Externí odkaz:
https://doaj.org/article/c3bea43b514049a2b49d50048f68fc6a
Autor:
Lindsay M. Webb, Philip N. Tsichlis, Austin Kennemer, Makenzie Bevins, Stephanie A. Amici, Shouvonik Sengupta, Mireia Guerau-de-Arellano, Georgios I. Laliotis, Zayda L Piedra-Quintero, Claudia Edell, Janiret Narvaez Miranda
Publikováno v:
J Clin Invest
Protein arginine methyltransferase 5 (PRMT5) catalyzes symmetric dimethylation (SDM) of arginine, a posttranslational modification involved in oncogenesis and embryonic development. However, the role and mechanisms by which PRMT5 modulates Th cell po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18372f29e4df5e14009ee8bc889f137
https://europepmc.org/articles/PMC7108896/
https://europepmc.org/articles/PMC7108896/
Publikováno v:
Trends in Molecular Medicine. 23:546-562
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system. The inflammatory and neurodegenerative pathways driving MS are modulated by DNA, lysine, and arginine methylation, as evidenced by studies made possible by novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81986f283d3f034ab52f76093f94c201
https://doi.org/10.1016/j.molmed.2017.04.004
https://doi.org/10.1016/j.molmed.2017.04.004
Autor:
Stephanie A. Amici, Lindsay M. Webb, Janiret Narvaez-Miranda, Austin Kennemer, Mireia Guerau-de-Arellano, Claudia Edell, Shouvonik Sengupta
Protein Arginine Methyltransferase (PRMT) 5 catalyzes symmetric dimethylation of arginine, a post-translational modification involved in cancer and embryonic development. However, the role of PRMT5 in T helper (Th) cell polarization and Th cell-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa061a23ddc551352404fe41069f067
https://doi.org/10.1101/792788
https://doi.org/10.1101/792788
Autor:
Lindsay M. Webb, Janiret Narvaez Miranda, Stephanie A. Amici, Shouvonik Sengupta, Gregory Nagy, Mireia Guerau-de-Arellano
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) mediated by CD4+ T cells and modeled via experimental autoimmune encephalomyelitis (EAE). Inhibition of PRMT5, the major Type II arginine methyltransferase, suppresses pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb028cad8531ce025a86aee38558e4e
Autor:
Shouvonik Sengupta, Lindsay M Webb, Georgios Laliotis, Philip N Tsichlis, Mireia Guerau-de-Arellano
Publikováno v:
The Journal of Immunology. 204:76.7-76.7
Protein Arginine Methyltransferase (PRMT) 5 is an enzyme catalyzing symmetric dimethylation (SDM) of arginine. This post-translational modification is known to be involved in oncogenesis and embryonic development. Our previous work has shown that PRM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2e9551b53ffa4fe8da13754884f827d
https://doi.org/10.4049/jimmunol.204.supp.76.7
https://doi.org/10.4049/jimmunol.204.supp.76.7
Autor:
Zayda L. Piedra-Quintero, Shouvonik Sengupta, Lindsay M Webb, Stephanie A Amici, Georgios Laliotis, Philip N Tsichlis, Mireia Guerau-de-Arellano
Publikováno v:
The Journal of Immunology. 204:230.1-230.1
PRMT5 catalyzes symmetric dimethylation (SDM) on arginine residues. PRMT5 methylates histone H3 and H4 producing remodeling of chromatin and regulation of gene transcription. PRMT5 is induced after T cell activation. Furthermore, both PRMT5 inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0df56b9fa73e74149dd842b8e48720ea
https://doi.org/10.4049/jimmunol.204.supp.230.1
https://doi.org/10.4049/jimmunol.204.supp.230.1
Autor:
Shouvonik Sengupta, Lindsay M Webb, Janiret NarvaezMiranda, Stephanie A Amici, Claudia Edell, Mireia Guerau-de-Arellano
Publikováno v:
The Journal of Immunology. 204:150.17-150.17
Protein Arginine Methyltransferase (PRMT) 5 is a type-II methyltransferase involved in oncogenesis, embryonic and hematopoietic development. However, the role of PRMT5 T-cell biology is only now coming into focus. To evaluate PRMT5’s functions in T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9dd4adf8982cf4d98c39fdf0d9bcbcf
https://doi.org/10.4049/jimmunol.204.supp.150.17
https://doi.org/10.4049/jimmunol.204.supp.150.17
Autor:
Webb, Lindsay M., Webb
Over two million individuals worldwide are affected with the devastating autoimmune disease, multiple sclerosis (MS), and as of yet, there is no cure. MS is primarily diagnosed in young adults aged 20-40, resulting in a substantial socioeconomic burd
Autor:
Miriam Rodriguez-Sosa, Juan de Dios Ruiz-Rosado, Diana Martínez-Saucedo, Frank Robledo-Avila, Cesar Terrazas, Stephanie A. Amici, Steve Oghumu, Lindsay M. Webb, Abhay R. Satoskar, Hanna Cortado, Kyle A. Jablonski, Mireia Guerau-de-Arellano, Luis I. Terrazas, Santiago Partida-Sanchez
Publikováno v:
Scientific Reports
Helminths cause chronic infections and affect the immune response to unrelated inflammatory diseases. Although helminths have been used therapeutically to ameliorate inflammatory conditions, their anti-inflammatory properties are poorly understood. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e54d8a30b745e5c684534d09fc877f6